Application of Bone Morphogenetic Proteins in the Treatment of Clinical Oral and Maxillofacial Osseous Defects by Philip J. Boyne J Bone Joint Surg Am.

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Presentation transcript:

Application of Bone Morphogenetic Proteins in the Treatment of Clinical Oral and Maxillofacial Osseous Defects by Philip J. Boyne J Bone Joint Surg Am Volume 83(1 suppl 2):S146-S150 April 1, 2001 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 1 The effect of recombinant human bone morphogenetic protein (rhBMP-2)/collagen implants on bone regeneration in critical-sized hemi-mandibulectomy bone defects. Philip J. Boyne J Bone Joint Surg Am 2001;83:S146-S150 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 1 The effect of recombinant human bone morphogenetic protein (rhBMP-2)/collagen implants on bone regeneration in critical-sized hemi-mandibulectomy bone defects. Philip J. Boyne J Bone Joint Surg Am 2001;83:S146-S150 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 1 The effect of recombinant human bone morphogenetic protein (rhBMP-2)/collagen implants on bone regeneration in critical-sized hemi-mandibulectomy bone defects. Philip J. Boyne J Bone Joint Surg Am 2001;83:S146-S150 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 1 The effect of recombinant human bone morphogenetic protein (rhBMP-2)/collagen implants on bone regeneration in critical-sized hemi-mandibulectomy bone defects. Philip J. Boyne J Bone Joint Surg Am 2001;83:S146-S150 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 2 Effect of occlusal forces on the regenerated bone formed with use of implants of recombinant human bone morphogenetic protein-2 in a collagen carrier. Philip J. Boyne J Bone Joint Surg Am 2001;83:S146-S150 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 2 Effect of occlusal forces on the regenerated bone formed with use of implants of recombinant human bone morphogenetic protein-2 in a collagen carrier. Philip J. Boyne J Bone Joint Surg Am 2001;83:S146-S150 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 2 Effect of occlusal forces on the regenerated bone formed with use of implants of recombinant human bone morphogenetic protein-2 in a collagen carrier. Philip J. Boyne J Bone Joint Surg Am 2001;83:S146-S150 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 3 Creation of osseous maxillary defects resembling bilateral cleft palate in a child. Philip J. Boyne J Bone Joint Surg Am 2001;83:S146-S150 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 3 Creation of osseous maxillary defects resembling bilateral cleft palate in a child. Philip J. Boyne J Bone Joint Surg Am 2001;83:S146-S150 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 3 Creation of osseous maxillary defects resembling bilateral cleft palate in a child. Philip J. Boyne J Bone Joint Surg Am 2001;83:S146-S150 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 3 Creation of osseous maxillary defects resembling bilateral cleft palate in a child. Philip J. Boyne J Bone Joint Surg Am 2001;83:S146-S150 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 4 The effect of recombinant human bone morphogenetic protein (rhBMP-2) collagen implants on bone regeneration in the maxillary clefts. Philip J. Boyne J Bone Joint Surg Am 2001;83:S146-S150 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 4 The effect of recombinant human bone morphogenetic protein (rhBMP-2) collagen implants on bone regeneration in the maxillary clefts. Philip J. Boyne J Bone Joint Surg Am 2001;83:S146-S150 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 4 The effect of recombinant human bone morphogenetic protein (rhBMP-2) collagen implants on bone regeneration in the maxillary clefts. Philip J. Boyne J Bone Joint Surg Am 2001;83:S146-S150 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 5 Histomorphometric analysis of the amount of regenerated bone (calcified matrix) and marrow-vascular space (MV Space) formed in the maxillary clefts of animals treated with autogenous cancellous bone (A) or with rhBMP-2/collagen implants (B). Philip J. Boyne J Bone Joint Surg Am 2001;83:S146-S150 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 5 Histomorphometric analysis of the amount of regenerated bone (calcified matrix) and marrow-vascular space (MV Space) formed in the maxillary clefts of animals treated with autogenous cancellous bone (A) or with rhBMP-2/collagen implants (B). Philip J. Boyne J Bone Joint Surg Am 2001;83:S146-S150 ©2001 by The Journal of Bone and Joint Surgery, Inc.