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BMP3: To Be or Not To Be a BMP by Matthew E. Bahamonde, and Karen M Lyons J Bone Joint Surg Am Volume 83(1 suppl 1):S56-S62 March 1, 2001 ©2001 by The.

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Presentation on theme: "BMP3: To Be or Not To Be a BMP by Matthew E. Bahamonde, and Karen M Lyons J Bone Joint Surg Am Volume 83(1 suppl 1):S56-S62 March 1, 2001 ©2001 by The."— Presentation transcript:

1 BMP3: To Be or Not To Be a BMP by Matthew E. Bahamonde, and Karen M Lyons J Bone Joint Surg Am Volume 83(1 suppl 1):S56-S62 March 1, 2001 ©2001 by The Journal of Bone and Joint Surgery, Inc.

2 An unrooted tree of the transforming growth factor beta (TGF-β) superfamily. Matthew E. Bahamonde, and Karen M Lyons J Bone Joint Surg Am 2001;83:S56-S62 ©2001 by The Journal of Bone and Joint Surgery, Inc.

3 Figs. 2-A and 2-B Retrovirally produced bone morphogenetic protein 2 (BMP2) can induce ectopic bone formation. Matthew E. Bahamonde, and Karen M Lyons J Bone Joint Surg Am 2001;83:S56-S62 ©2001 by The Journal of Bone and Joint Surgery, Inc.

4 Figs. 2-A and 2-B Retrovirally produced bone morphogenetic protein 2 (BMP2) can induce ectopic bone formation. Matthew E. Bahamonde, and Karen M Lyons J Bone Joint Surg Am 2001;83:S56-S62 ©2001 by The Journal of Bone and Joint Surgery, Inc.

5 Fig. 3-A Infection of W-20-17 cells with pBABE-bone morphogenetic protein (BMP)-3 reduces alkaline phosphatase activity induced by BMP2. Matthew E. Bahamonde, and Karen M Lyons J Bone Joint Surg Am 2001;83:S56-S62 ©2001 by The Journal of Bone and Joint Surgery, Inc.

6 Fig. 3-B BMP3 inhibits BMP2 induction of a BMP-responsive element. Matthew E. Bahamonde, and Karen M Lyons J Bone Joint Surg Am 2001;83:S56-S62 ©2001 by The Journal of Bone and Joint Surgery, Inc.

7 Fig. 3-C BMP3 can activate the transforming growth factor beta (TGF-β)/activin-responsive element within the reporter construct p3TP-Lux. Matthew E. Bahamonde, and Karen M Lyons J Bone Joint Surg Am 2001;83:S56-S62 ©2001 by The Journal of Bone and Joint Surgery, Inc.

8 Histological sections of distal femoral metaphyses stained with modified Goldner's trichrome. Matthew E. Bahamonde, and Karen M Lyons J Bone Joint Surg Am 2001;83:S56-S62 ©2001 by The Journal of Bone and Joint Surgery, Inc.

9 Figs. 5-A and 5-B Diagrams showing models of activin antagonism of bone morphogenetic protein 2 (BMP2). Matthew E. Bahamonde, and Karen M Lyons J Bone Joint Surg Am 2001;83:S56-S62 ©2001 by The Journal of Bone and Joint Surgery, Inc.

10 Figs. 5-A and 5-B Diagrams showing models of activin antagonism of bone morphogenetic protein 2 (BMP2). Matthew E. Bahamonde, and Karen M Lyons J Bone Joint Surg Am 2001;83:S56-S62 ©2001 by The Journal of Bone and Joint Surgery, Inc.

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