All Saints Catholic School. http://leighhouse.typepad.com/advergirl/images/alka_seltzer_burger_1.jpg Science Fair 2014 What effect does the size of the Alka Seltzer tablet have on how long it bubbles? Student Name February 6,2014 All Saints Catholic School.

Acknowledgements The Young Scientist gratefully thanks: Dad- Helped the young scientist prepare the questions for the interview Mom- Helped with the note cards and in choosing an “appropriate” topic. Mr. Fred Jones, executive director of marketing for Bayer AG, who kindly answered many interview questions.

Learning about Alka-Seltzer Is Important: To help people understand chemical reactions and the properties of water Has Practical Applications Information learned is helpful to subjects who need help for upset stomach Information can help people to use this substance to safely clean surfaces like jewelry and metallic surfaces http://cache.lifehacker.com/assets/resources/2008/06/alka-seltzer-diy.png

Previous Research: This study owes a debt to the following scientists: Oswald Schmiedeberg (1838-1921) generally recognized as founder of modern pharmacology, the study of medicines to help people feel better. Published over 200 articles and books on the relationship between various medicines and their narcotic effects upon the human body professor of pharmacology at University of Stassburg in Latvia http://mega.chem.ut.ee/~faulbeer/pages/ajalugu_i/Oswalt_Schmiedeberg.jpg

John Jacob Abel(1857-1938) Approached biology with a first-rate training in chemistry Believed that the study of molecules and atoms was as important as the observation of cellular tissues first person to isolate adrenaline, an important body hormone http://www.aspet.org/uploadedImages/Abel,-John.gif?n=8817

Claude Bernard (1813-1878) Discovered the role of the pancreas in digestion http://upload.wikimedia.org/wikipedia/commons/b/b6/Claude_Bernard_lesson_1889.jpg Established the role of experimentation for the life sciences including the need for the hypothesis Studied the effects of poisons like curare and carbon monoxide

This study of the effect size has on the time Alka Seltzer bubbles is based on an understanding of: Mass Basic property of all particles of matter Amount of mass affects gravitational field of objects According to Isaac Newton, “Every mass attracts every other mass in the universe.” (Boundless). http://teachertech.rice.edu/Participants/louviere/Newton/newton.html

What is Alka Seltzer? An antacid and pain reliever that breaks up and dissolves the full feeling people get related to digestion Ingredients include aspirin and a combination of sodium bicarbonate, potassium bicarbonate, and anhydrous citric acid Makes a sound of plop-plop when dropped into a water solution – used for ads http://acupuncturerichmondva.com/images/stomach-ache.gif

How does Alka Seltzer work? When dropped into water, solid sodium bicarbonate and citric acid in tablets form sodium citrate, carbon dioxide, and water. (Senese).

What does Alka Seltzer do in the stomach? ) What does Alka Seltzer do in the stomach? Sodium citrate = weak base Stomach acid = mainly HCl (hydrochloric acid) So, Alka Seltzer neutralizes the acid by creating water and carbon dioxide gas http://www.bryanfields.com/samples/alka/product/how.html Na3C3H5O7 (aq) + 3HCl (aq)  H3C3H5O7 (aq) + 3NaCl(aq) (Senese).

What is effervescence? The production of bubbles or foaming created when chemicals mix and a chemical reaction occurs (What is the definition). Example: mixing of vinegar and baking soda Occurs when Alka Seltzer tablets mix with water SeparationsNow.comhttp://www.separationsnow.com/details/ezine/sepspec26430ezine/Fizz

What is a chemical reaction? Process that produces chemical change resulting in new substances forming that are different from the original substances Have reactants – substances before the reaction Have products-created as a result of the reaction Example of A Chemical Reaction http://www.mhhe.com/physsci/chemistry/chang7/esp/folder_structure/cr/m1/s2/ Alka Seltzer creates a chemical reaction when tablets mix with water

An Interview with Pharmacist, Fred Jones It is not recommended. The amount of fizz or full dissolution of the tablets could change meaning it’s longer for the medicine to take effect. Can I dissolve Alka Seltzer in a liquid other than water? The best temperature is room temperature. Cold water will slow down dissolution and warm water will can make it foam too much. What temperature of water should be used for Alka Seltzer? What if the tablets don’t fizz? This can be a sign that the tablets have started to break down. Don’t use them. http://www.picturesof.net/pages/090213-011042-874042.html

In summary, the following facts may be stated about Alka Seltzer: It has mass – the more mass, the more concentrated It neutralizes stomach acid and relieves pain It creates a chemical reaction when it reacts with water It creates effervescence, gas bubbles, when it mixes with water. It is most effective with room temperature water http://science.csustan.edu/byrd/chem1002/gasevol.htm

Based on the previous facts, the following hypothesis was developed: If the size of an Alka Seltzer tablet is increased, then the chemical reaction will occur faster because the increased concentration of the larger tablet will cause the carbon dioxide gas to escape from the water more quickly. http://www.middleschoolchemistry.com/lessonplans/chapter6/lesson2

Works Cited "Boundless." Weight of the Earth. Creative Commons Attribution ShareAlike 3.0, 2013. Web. 12 Jan. 2014. <https://www.boundless.com/physics/uniform-circular- motion-and-gravitation/newton-s-law-of-universal-gravitation/weight-of- the-earth/>. "Interview with Fred Jones." E-mail interview. 15 Dec. 2013. Web. "Mass." Definition of Mass. Creative Commons Attribution ShareAlike 3.0, n.d. Web. 13 Jan. 2014. <https://www.boundless.com/chemistry/definition/mass/>. Senese, Fred. "What Makes Alka Seltzer Tablets Fizz?" General Chemistry Online: FAQ: Chemistry of Everyday Life:. Frostburg.edu, n.d. Web. 12 Jan. 2014. <http://antoine.frostburg.edu/chem/senese/101/consumer/faq/why-does- alkaseltzer-fizz.shtml>.

Appendix A: Some Facts About Alka Seltzer Alka-Seltzer is an effervescent  antacid and pain reliever first marketed in 1956 by the Dr. Miles Medicine Company. Alka-Seltzer is marketed for relief of minor aches, pains, inflammation, fever, headache, heartburn, sour stomach, indigestion, and hangovers while neutralizing excess stomach acid. Alka-Seltzer is currently owned by Bayer Schering Pharma AG, Germany.