Biosynthesis of peptide hormones DNA (gene) Hormone.

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Presentation transcript:

Biosynthesis of peptide hormones DNA (gene) Hormone

Protein secretory pathway

rough endoplasmic reticulum Protein secretory pathway

Secretory pathway rough ER

Signal sequences & SRP

SRP (signal recognition particle)

Multiple hormone cleavage products pro-opiomelanocortin polypeptide (POMC) ACTH  -lipotropin  -MSH  -lipotropin  -MSH CLIP  -endorphin  -MSH MET-enk

Steroid hormone synthesis tissues involved in steroid hormone synthesis: testosterone estradiol

Steroid hormone synthesis synthesis occurs in cholesterol

Biosynthesis of steroids cholesterol (C27)

Gluco- and mineralo-corticoid synthesis glucocorticoid mineralorticoid

Androgen & estrogen synthesis androgen estrogens

Vitamin D synthesis UV light liver, kidney

Thyroid hormone synthesis thyroid hormone synthesis forms of active thyroid hormone:

Thyroid hormone biosynthesis

Biosynthesis of eicosanoids arachidonic acid

Biosynthesis of eicosanoids

Anti-inflammatory drugs & eisosanoids thromboxaneleukotriene inflammation response phospholipase A arachidonic acid fatty acids

Hormone delivery endocrine: paracrine: autocrine: neuroendocrine:

Plasma transport of hormones

Hormone turnover typical half-life peptide hormones steroid & thyroid hormones

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