1 OPTICAL QUALITY OF DUAL- OPTIC ACCOMMODATING INTRAOCULAR LENS Andrea Galvis, MD 1,3 a Ivan Ossma, MD MPH MSc 1,2, a Sanjeev Kasthurirangan, PhD 4, b.

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1 OPTICAL QUALITY OF DUAL- OPTIC ACCOMMODATING INTRAOCULAR LENS Andrea Galvis, MD 1,3 a Ivan Ossma, MD MPH MSc 1,2, a Sanjeev Kasthurirangan, PhD 4, b 1 Fundacion Valle del Lili, Cali-Colombia 2 Universidad Industrial de Santander, Bucaramanga-Colombia 3 Universidad Autonoma de Bucaramanga, Bucaramanga- Colombia 4 Abbott Medical Optics Inc, Irvine, USA Financial Disclosure a Consultant Abbott Medical Optics b Scientist at Abbott Medical Optics Inc. The Synchrony IOL is not currently FDA-approved

2 Synchrony Design  Anterior Optic 32 Diopters  Posterior Optic Divergent (negative) 2

3  Compare Optical Quality Pseudophakic Eyes  Monofocal IOL  Synchrony Dual Optic Accommodating IOL  Parameters  Objective iTrace aberrometry  Custom Matlab Software to calculate MTF  Subjective Contrast Sensitivity Testing  Optec 6500 Study Purpose

4 Study Population iTrace aberrometry Cycloplegia 3 mm zone Matlab Software to calculate MTF Monofocal IOL : 15 subjects (30 eyes) Synchrony IOL : 16 subjects (32 eyes)

5 iTrace - Matlab conversion

6 Results

7 Objective Measurements 3 mm pupil Difference 0.01 um

8 Best-focus MTF 3 mm pupil Differences are less than 10%

9 Mesopic Contrast Sensitivity p=0.61 Wilcoxon Rank Sum Test 9

10 Dual Optic Design DOES NOT affect optical or retinal image quality of the eye Objective evidence (iTrace, MTF) Subjective evidence (CSF) Contrast sensitivity of Synchrony is equivalent to that of monofocal IOLs Discussion

11 Discussion Effect of the slight spherical aberration on Synchrony would only yield 0.42 D of increased depth of focus Calculations based on Rocha’s work * The improved near vision of Synchrony patients MOST LIKELY due to true accommodation * Rocha KM. Using Adaptive Optics Simultion to Explore the Effect of Higher Order Aberrations on Depth of Focus for the Correction of Presbyopia. Wavefront Congress 2008

12 Conclusion Quality of Vision of Synchrony IOL similar to standard monofocal IOLs Measured Subjectively Measured Objectively Improved Near Vision with Synchrony Not related to increased depth of focus