Clinical application 1.Dx exercise intolerance 1.1  VO 2 max   VO 2 AT 1.2 RER >1.2 (HRmax is not achieved) 1.3  breathing reserve < 20% (N=20-40%)

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Presentation transcript:

Clinical application 1.Dx exercise intolerance 1.1  VO 2 max   VO 2 AT 1.2 RER >1.2 (HRmax is not achieved) 1.3  breathing reserve < 20% (N=20-40%) 1.4  SaO V E /VO 2 (ventilatory equivalent for oxygen) > 40 2.Dx exercise-induced bronchospasm (EIB) 3.Aerobic fitness evaluation

Research study Optimal level of physical activity in children and adolescent with chronic lung disease

Objectives To study the optimal level of physical activity in children and adolescents with CLD

Normal (n=18)CLD (n=18) Hx & PE PFT - Spirometry - Lung volumes - DLco Exercise stress test VO 2 at AT  correlate with physical activity Experimental design

Results - Chronic interstitial lung1 - Post lobectomy5 - Pulmonary hemosiderosis1 - Fibrotic lung3 - BPD2 - Asthma moderate persistent6 Chronic lung diseases:

Abnormal PFT Obstructive lung7 (FEV %pred) Restrictive lung7 (TLC %pred) Diffusion defect1 (DLco/VA = 77 %pred) Hyperinflation9 (RV/TLC %pred)

CLD (n = 18) Control (n = 18) P FVC FEV < FEV 1 /FVC FEF 25-75% TLC RV/TLC DLco/VA