ALZET Speakers Kit ALZET Osmotic Pumps www.alzet.com.

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Presentation transcript:

ALZET Speakers Kit ALZET Osmotic Pumps www.alzet.com

ALZET Osmotic Pump Advantages Ensure around-the-clock exposure to test agents at predictable levels Permit continuous administration of short half-life proteins and peptides Convenient method for chronic dosing of laboratory animals Minimize unwanted experimental variables and ensure reproducible, consistent results Eliminate the need for nighttime or weekend dosing Reduce handling and stress to laboratory animals Small enough for use in mice or very young rats Allow for targeted delivery of agents to virtually any tissue Cost-effective research tool ALZET Osmotic Pumps www.alzet.com

Injection vs. Infusion ALZET Osmotic Pumps www.alzet.com

Principle of Operation ALZET pumps have 3 concentric layers: Rate-controlling, semi-permeable membrane Osmotic layer Impermeable drug reservoir ALZET pumps work by osmotic displacement. Water enters the pump across the outer, semi-permeable membrane due to the presence of a high concentration of sodium chloride in the osmotic chamber. The entry of water causes the osmotic chamber to expand, thereby compressing the flexible reservoir and delivering the drug solution through the delivery portal. ALZET Osmotic Pumps www.alzet.com

ALZET Osmotic Pumps www.alzet.com

ALZET® osmotic pumps are available in three sizes www.alzet.com

ALZET Brain Infusion Kits Together with ALZET pumps, the Brain Infusion Kits permit the continuous delivery of test compounds to the CNS for extended periods of time without external connections, restraints, or frequent handling of laboratory animals. ALZET Osmotic Pumps www.alzet.com

Specifications of ALZET Brain Kits Brain Infusion Cannula Material (tube) Stainless steel Dimensions (steel tube) 28 gauge 30 gauge Material (elbow stop, flange) ID = 0.18 mm; OD = 0.36 mm ID = 0.16 mm; OD = 0.31 mm Polycarbonate Volume inside tube 0.32 µl 0.23µl Height Adjustment Spacers Material Dimensions (height) 0.5 mm Catheter Tubing Polyvinylchloride (Medical grade) Length 15 cm (approx.) Inside diameter 0.69 mm (± 0.08) Outside diameter 1.14 mm (± 0.08) Volume per 15 cm 56 µl (3.7 µl/cm) ALZET Osmotic Pumps www.alzet.com

ALZET Brain Infusion Kits ALZET Brain Infusion Kits are designed for targeted delivery to the cerebral ventricles or direct microperfusion of discrete brain structures. Available kits have slightly different cannula designs. ALZET Osmotic Pumps www.alzet.com

In vitro vs. in vivo pumping rate The typical pumping rate of the Model 2ML4 ALZET Osmotic Pump over time in Sprague Dawley rats after subcutaneous implantation (n=105) ALZET Osmotic Pumps www.alzet.com

Typical pumping rate of the Model 2002 ALZET Osmotic Pump over time (n-20) ALZET Osmotic Pumps www.alzet.com

ALZET Contact Information ALZET Customer Service (Pricing and Ordering) Toll free: 1-877-922-5938 Phone: 1-408-253-8574 Fax: 1-408-865-1406 Mailing Address DURECT Corporation P.O. Box 530 Cupertino, CA. 95015-0530 ALZET Technical Support Toll free: 1-800-692-2990 Phone: 1-408-367-4036 Fax: 1-408-865-1406 Web Address www.alzet.com ALZET Osmotic Pumps www.alzet.com