1. Electro-osmotic drug delivery technology
Ceramatec Inc.
2425 S. 900 W.
Salt Lake City, Utah 84119

2. Implantable electro osmotic pump
Driven galvanically by two electrodes on board that controllably promote electro-osmosis
Fluid is pumped from the body into a chamber, expelling the contents controllably from a drug reservoir
Catheter from pump can be routed to treatment site
Pump can be remotely controlled
Successfully demonstrated in rabbits
Implantation site after 8 weeks delivery
Applications?
Chronic pain
Anti-biotics
Hormones
RNA therapy
Intra cranial delivery
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What does device do?
Device with drug is implanted into the body
Device delivers drug over slow steady rate
0.5 to 10 µL per hour
Week to months duration
Rate is controllable and can be shut off or turned on from out side the body
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What is the advantage?
Size efficiency
Low rate capable
Shut off capability
No need to explant if adverse drug reaction occurs
Reduced infection
No penetration through skin to infect
Convenient
Device can be placed near the skin surface for easy shut off and catheter routed to target area
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5. How does the technology work?
Water and ions from the body electro-osmotically pass through a membrane and enter a chamber
AgCl + e- → Ag + Cl-
½ Zn → ½ Zn++ + e-
AgCl + ½ Zn + → Ag + ½ ZnCl2
Na+ + water pass through cation exchange membrane
e- flows through circuit e- e-
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6. How does the technology work?
The water and ions press on a flexible member and force the drug through a catheter
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7. How does the technology work?
Rate is determined by the resistance of an electrical circuit between galvanic electrodes
Device is shut off when circuit is opened by any of several methods
Sealed latching magnetic switch
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8. Fast Shut-off Response
Compartmentalization
Peclet number – Pe
= transport due to convection/transport due to diffusion
= Q x L / N x D x A
Q = flux
L = flow channel length
N = number of channels
D = diffusion coefficient
A = area of individual channels
In vitro testing
Faster response found with rising Pe #
<15 minute shut off
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9. Has the device been tested invivo?
3 rabbit models have been studied, each with design improvements
E-beam sterilized
Devices delivered at 1.4 µL per hour over 8 weeks
Histopathology showed no adverse tissue reactions around implant
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10. Electro-osmotic summary
Implantable technology developed to deliver at low rates over several weeks to months
Utilizes electro-osmosis
Very small volume relative to payload
Can be turned on and off after implantation
Negligible interaction with tissues
Implantation site after 8 weeks delivery
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11. What are contemplated applications?
Delivery of pain medication to spine
Delivery of anti-biotics to internal infections
Delivery of chemotherapy drugs to tumors or cancers
We welcome your thoughts regarding the best uses of this technology
What drugs?
What therapies?
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12. Drug delivery technologies
What Ceramatec is seeking:
Specific applications
Strategic partners for specific applications
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Contact information
John Gordon
Ceramatec Inc.
2425 South 900 West
Salt Lake City, UT 84119
USA
cell:
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