Cellular Physiology of Secretion and Absorption Johnson Chap. 34-35 Jack L. Leonard 2004.

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Presentation transcript:

Cellular Physiology of Secretion and Absorption Johnson Chap Jack L. Leonard 2004

Johnson Chap FluidVolume(ml/day)pH Saliva Stomach (gastric secretion) Pancreas (exocrine secretion) Bile secretion Brunner’s gland secretion Succus entericus (intestinal juice) (intestinal juice) Large intestine Daily Secretion of Digestive Fluids

Johnson Chap Na Na P K K K Na Outside Inside Apical membrane Basolateral membrane Basic Secretory Mechanisms (Gut lumen) (interstitial space) Redrawn from Acta Physiologica Scand. 42:298, 1958

Johnson Chap Apical Membrane Johnson Chap (Gut lumen) (interstitial space) POutsideInside Apical Basolateral Na + K+K+K+K+ Cl - Channels Na + glucose Na + coupled organic Cl - HCO 3 - Antiporter Na + K+K+K+K+ 2Cl - Symporter Apical Surface

Johnson Chap Basolateral Membrane Johnson Chap Na + H+H+H+H+Antiporter K+K+K+K+ 2Cl - Symporter K+K+K+K+ ActiveTransporter Na + ATP (Gut lumen) OutsideApical Basolateral P (interstitial space) Inside Basolateral Surface

Johnson Chap Na + (mM) (Intracellular) (Intracellular) Transport Rate Na Pump Transport Rate

Johnson Chap Gut lumen interstitial space Cl - Na + K+K+K+K+ Cl - Na + K+K+K+K+ K+K+K+K+ Salt Secretion interstitial space Salt Absorption Na + K+K+K+K+ K+K+K+K+ Cl - Na +

Johnson Chap Ion concentration (mM) Flow (ml/min) Na HCO 3 Cl K Ion concentration (mM) NaCl HCO 3 K Saliva Plasma Salivary Duct Cell

Secretion of Na +, K +, and Cl - Salivary Acinar Cell Johnson Chap Na Na Na + K+K+K+K+ Cl - K+K+K+K+ ATP Na + K+K+K+K+ Cl - K+K+K+K+ Lumen Serosal surface stimuli

Johnson Chap Na + K + Cl - CO 2 K+K+K+K+ ATP Na + Cl - K+K+K+K+ Lumen Serosal surface Na + H+H+H+H+ CO 2 H 2 CO 3 HCO 3 - Na + K + Cl - HCO 3 - Salivary Duct Cell

Johnson Chap Ion concentration (mM) Flow (ml/min) Na HCO 3 Cl K Ion concentration (mM) NaCl HCO 3 K Saliva Plasma Salivary Duct Cell

Johnson Chap Secretion rate (ml/hr) Ion Concentration (mM) pH Osmolality Osm pH Na + HCO 3 - Cl - K+K+K+K+ Pancreatic Secretion

Johnson Chap Intestinal Absorbing Cell Na + K+K+K+K+ Cl - Cl Cl K+K+K+K+ATP Na + K+K+K+K+ Lumen Serosal surface glucose Na + Cl - HCO 3 - K+K+K+K+ ATP Na +

Intestinal Secretory Cell Johnson Chap Na Na Na + K+K+K+K+ Cl - K+K+K+K+ATP Na + Cl - K+K+K+K+ Lumen Serosal surface stimuli K+K+K+K+ ATP Na +