Evaluation of Articular Cartilage Progenitor Cells for the Repair of Articular Defects in an Equine Model by David D. Frisbie, Helen E. McCarthy, Charles.

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Presentation transcript:

Evaluation of Articular Cartilage Progenitor Cells for the Repair of Articular Defects in an Equine Model by David D. Frisbie, Helen E. McCarthy, Charles W. Archer, Myra F. Barrett, and C. Wayne McIlwraith J Bone Joint Surg Am Volume 97(6): March 18, 2015 ©2015 by The Journal of Bone and Joint Surgery, Inc.

Mean lameness grade (and standard error of the mean) averaged over the study time period (Fig. 1-A) and according to time (Fig. 1-B). David D. Frisbie et al. J Bone Joint Surg Am 2015;97: ©2015 by The Journal of Bone and Joint Surgery, Inc.

Mean radiographic grade (and standard error) of sclerosis (Fig. 2-A) and central osteophytes (Fig. 2-B) averaged over time. David D. Frisbie et al. J Bone Joint Surg Am 2015;97: ©2015 by The Journal of Bone and Joint Surgery, Inc.

Mean arthroscopic grade (and standard error) of repair tissue firmness (Fig. 3-A), overall repair tissue grade (Fig. 3-B), and volume of defect filling (Fig. 3-C) estimated at the time of the post mortem examination. David D. Frisbie et al. J Bone Joint Surg Am 2015;97: ©2015 by The Journal of Bone and Joint Surgery, Inc.

Representative photomicrographs from the control (Fig. 4-A) and allograft (Fig. 4-B) groups demonstrating increased inflammatory cells in the subchondral bone. David D. Frisbie et al. J Bone Joint Surg Am 2015;97: ©2015 by The Journal of Bone and Joint Surgery, Inc.

Figs. 5-A and 5-B Cartilage histology at twelve months. David D. Frisbie et al. J Bone Joint Surg Am 2015;97: ©2015 by The Journal of Bone and Joint Surgery, Inc.