DZ E E d b c a Flow Diagram 2x2 Table Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables & “fit” Designs, Diagrams, and Tables Healthy People - E E DZ

1 How is this disease distributed? Hypotheses 3 Is the association causal? 4 What should be done to prevent the disease? 5 Did the prevention strategy work? Where are we and where are we going? What’s my hypothesis? 2 Is there an association? Did the exposure and the disease turn up together? Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

Controlled Trial Cohort Study Case-Control Study E E E E DZ Cross-Sectional Study Review Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

Controlled Trial Cohort Study Case-Control Study Cross-Sectional Study Healthy People - E Random Assignment E DZ Healthy People - E E DZ - E E E E - E E Review Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E d b c a Flow Diagram 2x2 Table & “fit” Designs, Diagrams, and Tables Healthy People - E E DZ Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

& Designs, Diagrams, and Tables Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E a 2x2 Table Where do these people “fit” in the 2x2 table? Flow Diagram Controlled Trial Healthy People E E DZ Random Assignment Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E b Flow Diagram 2x2 Table Healthy People E E DZ Random Assignment Where do these people “fit” in the 2x2 table? Controlled Trial Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E c Flow Diagram 2x2 Table Flow Diagram Healthy People E E DZ Random Assignment Where do these people “fit” in the 2x2 table? Controlled Trial Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E d 2x2 Table Flow Diagram Healthy People E E DZ Random Assignment Where do these people “fit” in the 2x2 table? Controlled Trial Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E c Flow Diagram 2x2 Table Where are these people in the flow diagram? Cohort Study Healthy People E E DZ Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E a 2x2 Table Where are these people in the flow diagram? Flow Diagram Cohort Study Healthy People E E DZ Healthy People Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E d Flow Diagram 2x2 Table Where are these people in the flow diagram? Cohort Study Healthy People E E DZ Healthy People Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E b Flow Diagram 2x2 Table Where are these people in the flow diagram? Cohort Study Healthy People E E DZ Healthy People Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E a Where do these people go in the 2x2 table? 2x2 Table Flow Diagram Case-Control Study DZ E E E E Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E c Where do these people go in the 2x2 table? Flow Diagram 2x2 Table Case-Control Study DZ E E E E Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

Flow Diagram DZ E E b 2x2 Table Where do these people go in the 2x2 table? Case-Control Study DZ E E E E Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

Flow Diagram DZ E E d 2x2 Table Where do these people go in the 2x2 table? Case-Control Study DZ E E E E Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E a Flow Diagram 2x2 Table Where do these people go in the 2x2 table? Cross-Sectional Study E E DZ Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E c Flow Diagram 2x2 Table Where do these people go in the 2x2 table? Cross-Sectional Study E E DZ Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E d Flow Diagram 2x2 Table Where do these people go in the 2x2 table? Cross-Sectional Study E E DZ Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E b Flow Diagram 2x2 Table Where do these people go in the 2x2 table? Cross-Sectional Study E E DZ Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

Assessment Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E Flow Diagram 2x2 Table Where do these people “fit” in the 2x2 table? 1. a b c d E E DZ Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E 2x2 Table Where do these people “fit” in the 2x2 table? Flow Diagram 2. a b c d Flow Diagram Healthy People E E DZ Random Assignment Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E Where do these people “fit” in the 2x2 table? 2x2 Table Flow Diagram 3. a b c d DZ E E E E Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E Flow Diagram 2x2 Table Where do these people “fit” in the 2x2 table? 4. a b c d E E DZ Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E Flow Diagram 2x2 Table Where do these people “fit” in the 2x2 table? 5. a b c d Healthy People E E DZ Random Assignment Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

Flow Diagram DZ E E 2x2 Table Where do these people “fit” in the 2x2 table? 6. a b c d DZ E E E E Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E Flow Diagram 2x2 Table Where do these people “fit” in the 2x2 table? 7. a b c d E E DZ Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E Flow Diagram 2x2 Table Where do these people “fit” in the 2x2 table? 8. a b c d Healthy People E E DZ Random Assignment Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E Where do these people “fit” in the 2x2 table? Flow Diagram 2x2 Table 9. a b c d DZ E E E E Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E Flow Diagram 2x2 Table Where do these people “fit” in the 2x2 table? 10. a b c d E E DZ Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E a Flow Diagram 2x2 Table Where do these people “fit” in the 2x2 table? 1. (Answer) E E DZ Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E a 2x2 Table Where do these people “fit” in the 2x2 table? Flow Diagram 2. (Answer) Healthy People E E DZ Random Assignment Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E a Where do these people “fit” in the 2x2 table? 2x2 Table Flow Diagram 3. (Answer) DZ E E E E Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E b Flow Diagram 2x2 Table Where do these people “fit” in the 2x2 table? 4. (Answer) E E DZ Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E b Flow Diagram 2x2 Table Where do these people “fit” in the 2x2 table? 5. (Answer) Healthy People E E DZ Random Assignment Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

Flow Diagram DZ E E b 2x2 Table Where do these people “fit” in the 2x2 table? 6. (Answer) DZ E E E E Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E c Flow Diagram 2x2 Table Where do these people “fit” in the 2x2 table? 7. (Answer) E E DZ Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E c Flow Diagram 2x2 Table Where do these people “fit” in the 2x2 table? 8. (Answer) Healthy People E E DZ Random Assignment Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E c Where do these people “fit” in the 2x2 table? Flow Diagram 2x2 Table 9. (Answer) DZ E E E E Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

DZ E E d Flow Diagram 2x2 Table Where do these people “fit” in the 2x2 table? 10. (Answer) E E DZ Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

CDC Does this all make sense to you? There are four basic study designs for testing hypotheses. Each design has a different plan for assessing exposure and disease. The plan for each design can be understood by: 1) thinking of a train ride from exposure to disease, and 2) constructing a flow diagram. Whatever the study design, the assessment of exposure and disease “fits” into a 2x2 table so that a sample’s exposure and disease can be classified, risks calculated, risks compared, and inferences made. Making Sense Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables

CDC Investigation 2-9 has ended. Designs, Diagrams, and Tables Detectives in the Classroom – Investigation 2-9: Designs, Diagrams, and Tables