Basic digestive processes: 4 process Digestion Digestion is the change of complex food substances into a simpler form to be absorbed. Basic digestive processes: 4 process [1] Motility: To mix & move forward the contents along the digestive tract [2] Secretion: of Enzymes Mucous electrolytes & H2O From Salivary glands Gastric glands Intestinal glands Pancreas Liver Accessory digestive system G.B. Exocrine Pancreas.

DIGESTION DIGESTION

[3] Digestion: [4] Absorption: Breakdown of complex food substances of diet into simple Units to be absorbed. Proteins  amino-acids Fat  Fatty acids + Glycerol Carbohydrate  glucose [4] Absorption: Transfer of the small digested units from G.I.T. into blood or lymph.

Alimentary canal: Is 4.5 meters in living person. 9 meters outside body. It is a muscular tube. Its lumen is continuous with external environment of both ends.

Mucosal cell layer: Submucosal layer: Its surface is folded with ridges & valleys to  surface area. Contains exocrine cells for secretion of enzymes & mucous. Contains endocrine cells for secretion of hormones. Submucosal layer: Contains Blood & lymph vessels. Connective tissue. Meissners plexus.

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Muscular layer: Serosal layer: Inner Circular. to constrict diameter. Outer Longitudinal. to shorten length. In between Myentric plexus. = Auerbach’s plexus. Myenteric plexus is connected to Meissner’s plexus. Function: Propulsive & mixing movements. Serosal layer: Outer covering of G.I.T. to prevent friction with viscera exception: esophagus & distal rectum. Muscles of G.I.T. is Smooth except( i.e. striated): Pharynx. Upper 1/3 of esophagus. External anal sphincter. Middle 1/3 of esoph. is mixed. Lower 1/3 is smooth.

Autonomous Neural Hormonal Neural Regulation Regulation of G.I.T. functions Autonomous Neural Hormonal Neural Regulation Enteric nervous system = Local nerves plexuses External autonomic nerves Meissner’s plexus for secretion Myentric plexus = Auerbach’s for motor activity Para. Symp. Symp. Vagal Sacral

Enteric nervous system: 80-100 million nerve cells. The 2 plexus are connected by interneurones. It controls secretion & motility of G . I . T. Cutting both symp & parasymp., both secretion & motility will continue due to the activity of enteric nervous system. Both parasymp & symp modify (modulate, regulate) the functions of enteric n. plexus. Autonomic control: Nor-ep. Relax wall Contract sphinct. ? Secretion Ac. ch. contract wall Relax sphincter  Secretion Ch. trans. effect Postganglionic Coeliac, sup. & inf. mesent. Preganglionic peripheral Fibre ganglia Sacral (S2,3,4 pelvis nerve) T5 – L2 Cranial (mainly vagus) Origin Symp. Parasymp

Short Long Regulation of G.I.T. functions = Local axon reflex Receptors either in i.e. the components of this reflex are present in the wall of G.I.T. Wall of G.I.T. Outside G.I.T. UNCONDITIONED REFLEX Vision Hearing Smell Thinking Centre: enteric nervous system i.e. it is a reflex that does not reach to spinal cord or brain CONDITIONED REFLEX

Types of Receptors in G.I.T. [1] Chemoreceptors [2] Mechanoreceptors [3] Osmoreceptors i.e. receptors sensitive to chemical stimuli e.g. Acid (HCL), glucose, amino-acids,Fatty acids (Pressure receptors) Sensitive to distension (Stretch) Sensitive To Osmolality inside G.I.T. e.g. Hypertonic, Hypotonic solutions Neural Supply to bl. vessels of GIT: [1] [2] [3] N.B.: Parasymp.   secretion   end products of metabolism  V.D. i.e. indirect Cholinergic fibres to splanchnic bl. v. No direct nor-ep. V.C. Symp. VIP V.D. Enteric n. system

Blood flow to mucosa > wall After meal blood flow to G.I.T. is doubled and continue for 3 hours. = Postprandial Hyperaemia It is due to: {1}  metabolism   end products  V.D. {2}  V.D. peptides as VIP Bradykinin Adenosine CCK

All G.I.T. hormones are Polypeptides. Hormonal Regulation All G.I.T. hormones are Polypeptides. These hormones are secreted from mucosal cells called APUD cells. ( Amine Precursor Uptake & Decarboxylation.) these cells can take up amine precursor and decarboxylate them. These hormones will circulate in blood. These hormones affect ( or ) both secretion & motility of G.I.T. These hormones are released in response. To External autonomic nerves. Enteric nervous system. N.B.: Some hormones may act. Locally i.e. not pass to blood i.e. affected nearby cells. = Paracrine secretion.

Site of Release: Stimuli for release: Gastrin Hormones G-cells in mucosa of antrum of stomach. TG cells in mucosa of Stomach. Duodenum. Mechanism: Local axons reflex. Stimuli for release: Products of proteins as peptides & a-a in stomach & duodenum. Distension of the antrum of stomach & duodenum  vagal discharge The chemical transmitter is GRP not ac.ch. GRP i.e. gastrin releasing peptide. N.B.: Atropine does not prevent gastrin release  Hcl   gastrin release by direct effect on G-cells.

Actions of gastrin (Functions, Effects):  Hcl secretion.  Pepsinogen.  gastric motility  ileal “ Relax ileocecal sphincter  mass movement of colon Trophic ( growth) of stomach & S.intestine N.B.: Zollinger Elison syndrome Tumor in delta cells of pancreas, secretion gastrin hormone = Gastrinoma

Secretion hormone Site of Release: Site of Release: S. cells of duodenum and presence of product jejunum of protein digestion and ?????. Stimulus: Presence of Hcl in duodenum. Mechanism: Local axon reflex. Actions: Functions:  secretion of NaHCO3 from duct of pancreas  to neutralize Hcl. Choleretic i.e.  Hepatic bile 7-8 to neutralize Hcl.  gastric Hcl  “ motility N.B.: Decrease gastric motility and emptying to present further acid from entering the duodenum until the acid that is already present is neutralized. Contraction of pyloric sphincter to prevent further acid passage into duodenum (to give a chance to neutralize Hcl in duodenum. N.B.: The effect of secretion ?????? to: Increase alkaline pancreatic and bile juices to neutralise the acid in the duodenum that trigger ????????? there release of this hormone.

CCK – PZ Cholecystokinin – Pancreozymin Site of Release: ???????????? I cells in duodenum upper brain + ?????? Stimulus: Proteins products in duodenum Fats in “ Action: Functions: Contract wall of G.B. (cholagogue) & relax Oddi sphincter to digest fat.  pancreatic secretion rich in enzymes.  gastric motility.  “ secretion. Contract pyloric sphincter, till the protein & fat in duodenum are digested. Trophic effect on pancreas. Pancreatic juice rictin enzyme and  bile faring all blader acini ?????? if fat and plotter products in the duodenum that triggered. the release this hormone. Gastric motility and emptying  allowing adequate time for the nutrients ??? present in the duodenum to be digested and absorbed.