Michael Marron, Ph.D., Director Division of Biomedical Technology National Center for Research Resources National Institutes of Health Department of Health and Human Services Biomedical Informatics Research Network

26 Nov BIRN Biomedical Informatics Research Network A testbed for a biomedical knowledge infrastructure Federated database of neuroimaging data Fusion of diverse data sources (location; level of aggregation) Grid access to computational resources Datamining software Scalable and extensible Driven by research needs-pull, not technology-push

26 Nov BIRN Infrastructure Establish a stable high performance network linking key Biotechnology Centers and General Clinical Research Centers using Internet2 Establish a stable high performance network linking key Biotechnology Centers and General Clinical Research Centers using Internet2 Establish distributed and linked data collections with partnering groups Establish distributed and linked data collections with partnering groups Enable the use of "grid-based" computing resources for project specific data refinements and comparisons Enable the use of "grid-based" computing resources for project specific data refinements and comparisons Enable data mining from multiple data collections or databases on neuroimaging Enable data mining from multiple data collections or databases on neuroimaging Build a stable software and hardware infrastructure that will allow centers to coordinate efforts to accumulate larger studies than can be carried out at one site. Build a stable software and hardware infrastructure that will allow centers to coordinate efforts to accumulate larger studies than can be carried out at one site.

BIRN Sites

Information Integration protein localization What is the cerebellar distribution of rat proteins with more than 70% homology with human NCS-1? Integrated View Mediator morphometry neurotransmission Web CaBP, Expasy Wrapper Integrated View Definition

26 Nov Mouse BIRN Animal Models of Disease /Multi Scale/Multi Method - MS Mouse and DAT KOM (a schizophrenic and otherwise interesting mouse animal model) Animal Models of Disease /Multi Scale/Multi Method - MS Mouse and DAT KOM (a schizophrenic and otherwise interesting mouse animal model) Looking at different resolutions by combining data from multiple modalities Looking at different resolutions by combining data from multiple modalities Duke, UCLA, UC San Diego, Cal Tech Duke, UCLA, UC San Diego, Cal Tech

26 Nov Morphology BIRN Neuroanatomical correlates of neuropsychiatric illness (unipolar depression, Alzheimer's disease, mild cognitive impairment) Neuroanatomical correlates of neuropsychiatric illness (unipolar depression, Alzheimer's disease, mild cognitive impairment) - Overcome obstacles to the use of neuroimaging data as quantitative outcome measures for clinical investigation including issues raised by longitudinal and multi-site studies. - Do structural differences contribute to specific symptoms such as memory dysfunction or depression independent of diagnosis? - Do specific structural differences distinguish specific diagnostic categories? Harvard (MGH and BWH), Duke, UCLA, UC San Diego, Johns Hopkins, UC Irvine Harvard (MGH and BWH), Duke, UCLA, UC San Diego, Johns Hopkins, UC Irvine

26 Nov Functional BIRN Characterizing the collection and integration of fMRI data from multiple sites Characterizing the collection and integration of fMRI data from multiple sites Study schizophrenia through fMRI images collected from patients around the country using standardized protocols Study schizophrenia through fMRI images collected from patients around the country using standardized protocols UCLA, UC San Diego, UC Irvine, Harvard (MGH and BWH), Stanford, Minnesota, Iowa, New Mexico, Duke, North Carolina UCLA, UC San Diego, UC Irvine, Harvard (MGH and BWH), Stanford, Minnesota, Iowa, New Mexico, Duke, North Carolina

26 Nov BIRN Coordinating Center UC San Diego UC San Diego Best practices aggregator Best practices aggregator Technical development center Technical development center Center for training and experience exchange Center for training and experience exchange Expert-level technical support Expert-level technical support High-level project management High-level project management Oversight bodies point of contact Oversight bodies point of contact Gigabit/10/100 Network Switch – Cisco4006 Network Statistics System Gigabit Ethernet Network Probe Network Attached Storage – Gigabit Ether 1.0 to 8.0 TB Grid POP SRB, Globus Dual Processor Linux w/ 1GB memory DL 380 General purpose Specialized encryption UPS for Rack Uniform Hardware for BIRN Sites N2400 NAS 1.0 TB Cisco 4006 DL380 Grid POP DL380 DL380 - Network Stats GigE Net Probe APC UPS NCRR

26 Nov Challenges Large data sets ISCAR - information storage, curation, archiving, and retrieval ISCAR - information storage, curation, archiving, and retrieval Bandwidth issues Bandwidth issues Quality control of data only analyzed by machine Quality control of data only analyzed by machine Visual interfaces for complex data sets Visual interfaces for complex data sets Fostering collaboration Reward structures in government and academic institutions Reward structures in government and academic institutions Intellectual property issues Intellectual property issues Data integrity Data integrity Resistance to collaborate with competitors Resistance to collaborate with competitors Data sharing issues (ownership, privacy, authorship)

26 Nov More Challenges Federated DB /Knowledge Engineering Dictionaries & Ontologies Dictionaries & Ontologies Integrating different data types Integrating different data types Accessing legacy systems Accessing legacy systems Distributed query computations Distributed query computations High-level management of projects Overcome technical & institutional barriers Overcome technical & institutional barriers Degree of centralization needed Degree of centralization needed Role of standards Role of standards Project subdivision and optimization Project subdivision and optimization

26 Nov BIRN Future Addition of new sites in a rapid, well-defined, affordable fashion Addition of new sites in a rapid, well-defined, affordable fashion Grid-based National Clinical Research Network Grid-based National Clinical Research Network Cross-species integration of data Cross-species integration of data Characterization of treatment at multiple levels Characterization of treatment at multiple levels Expand model to other areas of biomedical research Expand model to other areas of biomedical research