1. All Hands Meeting 2005 BIRN-CC: Building, Maintaining and Maturing a National Information Infrastructure to Enable and Advance Biomedical Research

2. Biomedical Informatics Research Network A Shared Biomedical IT Infrastructure to Hasten the Derivation of New Understanding and Treatment of Disease through use of Distributed Knowledge Connect distributed multi-scale biomedical data and researchers Open access to data and tools Bring Transparent GRID Computing to Biomedical Research Grow Interdisciplinary Biomedical Informatics Workforce >Translation

3. Overview of the BIRN-CC Roadmap  Be the vehicle for bringing advanced cyberinfrastructure to the larger biomedical community  Deliver and maintain a robust and scalable PRODUCTION Grid for the collaborative sharing, analysis and interrogation of biomedical data  Provide integrated solutions for core BIRN functions  Provide a consistent and scalable delivery mechanism BIRN has developed an “End-to-End” Production Infrastructure in the context of distributed biomedical research projects.

4. BIRN-CC Enables Test Bed Science  A stable, robust, shared network and distributed database environment  Extensible tools and IT infrastructure that can be reused.  Established cyberinfrastructure for data grid and large scale data integration effort  High performance connectivity between distributed resources (computation and data storage)  Seamless access to distributed high performance computing resources Changing the use pattern for research data from the individual laboratory/project to shared use.

5. THE BIOMEDICAL INFORMATICS RESEARCH NETWORK LAYOUT FOR PHASE 1 From the Expanding the BIRN Meeting @ NCRR: December. 6 & 7, 2001) At the beginning

6. The BIRN Collaboratory Today Enabling collaborative research at 28 research institutions comprised of 37 research groups. It will no longer matter where data, instruments and computational resources are located!

7. Hardware Integrated Cyberinfrastructure System meeting the needs of multiple communities Source: Dr. Deborah Crawford, Chair, NSF CyberInfrastructure Working Group Grid Services & Middleware Development Tools & Libraries Applications Environmental Science High Energy Physics Biomedical Informatics Geoscience Domain- specific Cybertools (software) Shared Cybertools (software) Distributed Resources (computation, communication storage, etc.) Education and Training Discovery & Innovation

8. BIRN Core Software Infrastructure Distributed Resources BIRN builds on evolving community standards for middleware Adds new capabilities required by projects Does System Integration of domain-specific tools building a distributed infrastructure Utilizes commodity hardware and stable networks for baseline connectivity

9. Distributed Resources BIRN builds on evolving community standards for middleware Adds new capabilities required by projects Does System Integration of domain-specific tools building a distributed infrastructure Utilizes commodity hardware and stable networks for baseline connectivity Grid Services & Middleware Development Tools & Libraries Shared Tools for Multiple Science Domains Distributed Computing, Instruments and Data Resources Your Specific Tools & User Apps. Friendly Work Facilitating Portals Authentication - Authorization - Auditing - Workflows - Visualization - Analysis BIRN Core Software Infrastructure

10. Distributed Resources BIRN builds on evolving community standards for middleware Adds new capabilities required by projects Does System Integration of domain-specific tools building a distributed infrastructure Utilizes commodity hardware and stable networks for baseline connectivity Grid Services & Middleware Development Tools & Libraries Shared Tools Science Domains Distributed Computing, Instruments and Data Resources Your Specific Tools & User Apps. Friendly Work Facilitating Portals Authentication - Authorization - Auditing - Workflows - Visualization - Analysis Biomedical Informatics “BIRN” High Energy Physics GriPhyN Geosciences “GEON” Bays and Rivers (Moore Found.) Other Projects - caBIG - NIEHS? Ocean Observing “Looking”

11. BIRN is a Growing Consortium  NDAR - National Database for Autism Research for the support of clinical and translational research within the autism research community  Non-Human Primate - Linking imaging, behavior, and molecular informatics in non-human primate pre-clinical models of disease  UK e-Science - Fostering collaborations with European cyberinfrastructure community

12. BIRN is Directing the Evolution of Cyberinfrastructure  Shaping Portals -Web/GRID - Complexity Hidden  Building Transparent Distributed Data Collections “Data Grids”  Navigating Firewalls  Negotiating Security  Bringing Uniform Authentication to the GRID  Authorization levels that match collaborative work in biomedical research  Auditing that fits needs of clinical research studies conducted across institutional domains

13. Providing an Intuitive Interface to the BIRN Collaborative Environment Data Management The BIRN shared information technology infrastructure for basic and translational research is available to all researchers from any internet capable location. Data Visualization Distributed Computation

14. BIRN is a Leader in Portal Technology The BIRN-CC is supporting development of the leading open- source standards-based grid portal.

15. BIRN is Enabling Secure Collaboratories The BIRN Coordinating Center is deploying a common authentication and security infrastructure. Provides for Single Sign-On to access all portal, data and computational resourcees Available to all BIRN applications Will provide access to external resources (e.g. OptiPuter and TeraGrid) The BIRN Coordinating Center is deploying a common authentication and security infrastructure. Provides for Single Sign-On to access all portal, data and computational resourcees Available to all BIRN applications Will provide access to external resources (e.g. OptiPuter and TeraGrid) Single sign-on and credential management Full access control and audit logs for all data within the BIRN infrastructure Authentication service available to all BIRN applications

16. BIRN Enables Large Scale Data Sharing  BIRN Data Grid is a Distributed Data Handling System  Data has more than doubled since the 2004 AHM  Provides a scalable and distributed solution for distributing publicly available data

17. BIRN is a driver for advanced network projects