Figure 7.1 The Biology of Cancer (© Garland Science 2007) What’s dominant? Cell Fusion Allows Interaction Of Disparate Genomes
Retinoblastoma strikes in childhood and is easily diagnosed. RETINOBLASTOMA
Figure 7.5a The Biology of Cancer (© Garland Science 2007)
Figure 7.5b The Biology of Cancer (© Garland Science 2007) Familial vs sporadic Retinoblastoma Retinoblastoma Pedigree
Figure 7.8 The Biology of Cancer (© Garland Science 2007) Heterozygosity – 2 ways of Losing it Mitotic Recombination Gene Conversion
Figure 7.13 The Biology of Cancer (© Garland Science 2007) Testing For Loss of Heterozygosity By Southern Blot By PCR
Figure 7.14 The Biology of Cancer (© Garland Science 2007)
Figure 7.16 The Biology of Cancer (© Garland Science 2007) Losing Heterozygosity – A Third Way Methylation An example
Figure 7.19 The Biology of Cancer (© Garland Science 2007) Many Tumor Suppressors are Silenced by Hypermethylation
Figure 7.21 The Biology of Cancer (© Garland Science 2007) NF-1 – Neurofibromatotosis -1 is a GTPase Activating Protein
Figure 7.24a The Biology of Cancer (© Garland Science 2007) APC -/- APC +/- or +/+ APC, β-Catenin & Intestinal Crypts
Figure 7.25a The Biology of Cancer (© Garland Science 2007)
Figure 7.28a The Biology of Cancer (© Garland Science 2007) The Von Hippel Landau tumor Suppressor and HIF-1
Figure 7.29b The Biology of Cancer (© Garland Science 2007)