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The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients  Stephen J Elledge, Angelika Amon  Cancer.

Published byAna María Ríos Sosa Modified over 5 years ago

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Presentation on theme: "The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients  Stephen J Elledge, Angelika Amon  Cancer."— Presentation transcript:

1 The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients  Stephen J Elledge, Angelika Amon  Cancer Cell  Volume 1, Issue 2, Pages (March 2002) DOI: /S (02)

2 Figure 1 A schematic representation of the BRCA1 suppressor hypothesis as an explanation for breast and ovarian tissue specificity of cancer in BRCA1 heterozygous individuals See text for explanation. LOH: loss of heterozygosity. Colored circles represent cells of particular genotypes. Changes in circle color indicate a change in genotype. Cancer Cell 2002 1, DOI: ( /S (02) )

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