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Figure The Biology of Cancer (© Garland Science 2007)

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Presentation on theme: "Figure The Biology of Cancer (© Garland Science 2007)"— Presentation transcript:

1 Figure 11.12 The Biology of Cancer (© Garland Science 2007)

2 Figure 11.7 The Biology of Cancer (© Garland Science 2007)

3 Progressive Accumulation of Genetic Lesions in Colon Cancer
Progressive LOH The Corresponding genetic lesions Figure The Biology of Cancer (© Garland Science 2007)

4 APC , β-CATENIN & REGULATION OF THE INTESTINAL LINING
Figure 7.24a The Biology of Cancer (© Garland Science 2007)

5 Comparative Genome Analysis
Figure The Biology of Cancer (© Garland Science 2007)

6 In Vivo Studies With Monozygotic Twins Show Requirement For More Than 1 Genetic Modification
Figure 11.22b The Biology of Cancer (© Garland Science 2007)

7 Oncogene Collaboration
Table The Biology of Cancer (© Garland Science 2007)

8 In vivo Study in Mouse Model Shows effect of Collaborating Genetic Lesions
Figure 11.24a The Biology of Cancer (© Garland Science 2007)

9 Tumor Initiators and Tumor Promoters - Phenomenology
Figure The Biology of Cancer (© Garland Science 2007)

10 Initiators & Promoters – Possible Mechanisms I
Figure The Biology of Cancer (© Garland Science 2007)

11 Initiators & Promoters – Possible Mechanisms II
Figure The Biology of Cancer (© Garland Science 2007)

12 Table 11.4 The Biology of Cancer (© Garland Science 2007)

13 Inflammation and Liver Cancer
Figure 11.37b The Biology of Cancer (© Garland Science 2007)

14 Inflammation, Cyclooxygenase-2 (COX-2), Prostaglandin E2 & Tumor Promotion
Figure 11.38c The Biology of Cancer (© Garland Science 2007)

15 Alcohol – head & neck Table The Biology of Cancer (© Garland Science 2007)

16 Mutagens vs Promoters Figure The Biology of Cancer (© Garland Science 2007)


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