Genetics

Genetics and Behaviour For behaviour to be affected by natural selection, some variation in behaviour must be inherited If not, the characteristics could not be passed on right? Otherwise, could contribute to fitness, but could NOT evolve Remember, only heritable, genetically transmitted variation can be affected by selection For behaviour to be affected by natural selection, some variation in behaviour must be inherited If not, the characteristics could not be passed on right? Otherwise, could contribute to fitness, but could NOT evolve Remember, only heritable, genetically transmitted variation can be affected by selection

Introduction ‘Trying to determine how much of a behaviour is due to genetics and how much is due to the environment is like trying to determine how much the area of a field is caused by its length and how much by its width’ Donald Hebb Nature v. Nurture is a stupid argument ‘Trying to determine how much of a behaviour is due to genetics and how much is due to the environment is like trying to determine how much the area of a field is caused by its length and how much by its width’ Donald Hebb Nature v. Nurture is a stupid argument

Key Terms Gene Genotype Phenotype Chromosome Locus Allele Diploid Gene Genotype Phenotype Chromosome Locus Allele Diploid Haploid Gamete Zygote Recessive Dominant Homozygous Heterozygous

Note that it is not the case that the chromosomes just pair off, there is also recombination So, each sex cell is a little bit different

This Recombination is the source of much genetic variation, and it occurs in all but the simplest organisms Mutation is the ONLY source of new genetic material Most mutations are bad, usually lethal Some are neutral Some (very few) confer an advantage This Recombination is the source of much genetic variation, and it occurs in all but the simplest organisms Mutation is the ONLY source of new genetic material Most mutations are bad, usually lethal Some are neutral Some (very few) confer an advantage

How DNA works Base pairs Adenine Thymine Cytosine Guanine C -> G A -> T Base pairs Adenine Thymine Cytosine Guanine C -> G A -> T

DNA and genes Genes encode proteins DNA -> RNA RNA -> Proteins Proteins -> phenotype Environment -> genes Though some genes are less responsive than others Genes encode proteins DNA -> RNA RNA -> Proteins Proteins -> phenotype Environment -> genes Though some genes are less responsive than others

An Example Human Ocular cutaneous albinism I wonder where that example came from….. Single gene for the production of melanin A – normal a - bad Dominance / Recessive relationship AA, aA, Aa all lead to normal, aa leads to me Human Ocular cutaneous albinism I wonder where that example came from….. Single gene for the production of melanin A – normal a - bad Dominance / Recessive relationship AA, aA, Aa all lead to normal, aa leads to me

Leslie and Rick Aa and Aa Or some variation aA and Aa Aa and aA aA and aA Phenotypically normal Leslie and Rick Aa and Aa Or some variation aA and Aa Aa and aA aA and aA Phenotypically normal

1 in 4 chance of having a kid with aa They did, on June 23, 1965 My genotype MUST be aa because there is no dominance 1 in 4 chance of having a kid with aa They did, on June 23, 1965 My genotype MUST be aa because there is no dominance

Danny and Stephanie may be carriers, or they may not be, they are phenotypically normal Their kids could carry the allele, assuming they do Danny and Stephanie may be carriers, or they may not be, they are phenotypically normal Their kids could carry the allele, assuming they do They got the looks, but I got the brains……..

My kids MUST carry the allele, as they had an a from me, and, an A from Isabelle We know they got an A from Isabelle by looking at their phenotype My kids MUST carry the allele, as they had an a from me, and, an A from Isabelle We know they got an A from Isabelle by looking at their phenotype

Behavioural Effects I don’t spend much time in the sun I have very poor vision (20/200, melanin guides the growth of the visual system) No binocular vision Can’t drive a car Not very good at baseball Huge IQ……. I don’t spend much time in the sun I have very poor vision (20/200, melanin guides the growth of the visual system) No binocular vision Can’t drive a car Not very good at baseball Huge IQ…….

Partial Dominance Telleogryllus oceanicus and T. commodus Males call to attract mates (function) Song is species specific Male hybrids produce hybrid song Female hybrids prefer hybrid song. Telleogryllus oceanicus and T. commodus Males call to attract mates (function) Song is species specific Male hybrids produce hybrid song Female hybrids prefer hybrid song.

Another cool example Mutant hamsters Martin Ralph Tau gene TT normal 24 hr cycle tt 20 hr cycle Tt or tT gives 22 hr cycle Mutant hamsters Martin Ralph Tau gene TT normal 24 hr cycle tt 20 hr cycle Tt or tT gives 22 hr cycle

Teenage Mutant Ninja Hamsters Single Gene effect Affects brain development SCN specifically May be cognitive effects Single Gene effect Affects brain development SCN specifically May be cognitive effects

Learning Mutants in Drosophila The white rat of genetics Dunce Amnesia Stuck Coitus interruptus Bang sensitive Per This one is cool… The white rat of genetics Dunce Amnesia Stuck Coitus interruptus Bang sensitive Per This one is cool…

So why are there different alleles? On the surface, if some allele is better than some other, why does it not replace all other alleles? Neutral alleles? Environmental fluctuation Heterozygote superiority Frequency dependent selection And, of course, mutation On the surface, if some allele is better than some other, why does it not replace all other alleles? Neutral alleles? Environmental fluctuation Heterozygote superiority Frequency dependent selection And, of course, mutation

So, What Does it All Mean? What does ‘a gene for behaviour’ mean? Behavioural difference caused by genetic difference Does not mean that a complex behavioural sequence is caused by a single gene Many other genes contribute to behaviour Some difference must be caused by genetic differences Just because something has a genetic basis does not make in unchangeable!!!! What does ‘a gene for behaviour’ mean? Behavioural difference caused by genetic difference Does not mean that a complex behavioural sequence is caused by a single gene Many other genes contribute to behaviour Some difference must be caused by genetic differences Just because something has a genetic basis does not make in unchangeable!!!!

Remember, Genotype is NOT Phenotype