Chapter 19 Disorders of Cardiac Function Essentials of Pathophysiology Chapter 19 Disorders of Cardiac Function

PRE-LECTURE QUIZ F T Pericarditis represents an inflammatory process of the myocardium. All types of angina represent an acute myocardial infarction, also known as a heart attack. The heart extracts and uses 60% to 80% of the oxygen in blood flowing through the coronary arteries. Atherosclerosis is by far the most common cause of coronary heart disease. Stable atherosclerotic plaques tend to rupture more than unstable atherosclerotic plaques and lead to acute coronary syndromes, ranging from unstable angina to ST-segment elevation myocardial infarction.

PRE-LECTURE QUIZ  Cardiac __________ is a life-threatening, slow or rapid compression of the heart due to the accumulation of fluid, pus, or blood in the pericardial sac. Rheumatic heart disease, a disorder that follows a group A _____________ throat infection, is of great concern because of the potential effects of chronic valvular disorders that produce permanent cardiac dysfunction and sometimes fatal heart failure years later. __________ refers to a narrowing of the valve orifice and failure of the valve leaflets to close properly.  Creatine kinase, myoglobin, and troponin are known as serum cardiac __________ and are useful for acute myocardial infarction determination and classification. Coronary heart disease is a disorder of impaired __________ blood flow, usually caused by atherosclerosis. corornary Markers Stenosis Streptococcal Tamponade

Disorders That Affect the Whole Heart Pericardial disorders Coronary heart disease Myocardial diseases These disorders can cause symptoms of both right- and left-sided heart failure

The Pericardium Surrounds the Heart

Inflammation of the pericardium causes: Pericarditis Inflammation of the pericardium causes: Pain Exudate Serous  pericardial effusion Cardiac tamponade: rapid accumulation of exudate compresses the heart Fibrous  friction rub; adhesions ECG changes

Pericarditis (cont.) Inflammation of the pericardium may restrict the heart’s movement due to: Serous exudate filling the pericardial cavity (pericardial effusion) Fibrous scar tissue making the pericardium stick to the heart (constrictive pericarditis)

Consequences of Pericardial Effusion fluid in pericardial Consequences of Pericardial Effusion cavity restricts heart expansion left ventricle right ventricle cannot accept cannot accept enough blood enough blood decreased increased venous cardiac pressure; jugular output distension decreased blood pressure and shock

Question What is the immediate treatment for severe cardiac tamponade? Oxygen Cardiac drugs Surgery Pericardiocentesis (removal of fluid from the sac with a needle)

Inflammation of the pericardium causes: Pericarditis Inflammation of the pericardium causes: Pain Exudate Serous  pericardial effusion Cardiac tamponade: rapid accumulation of exudate compresses the heart Fibrous  friction rub; adhesions ECG changes

Pericarditis (cont.) Inflammation of the pericardium may restrict the heart’s movement due to: Serous exudate filling the pericardial cavity (pericardial effusion) Fibrous scar tissue making the pericardium stick to the heart (constrictive pericarditis)

Consequences of Pericardial Effusion fluid in pericardial cavity Consequences of Pericardial Effusion restricts heart expansion left ventricle right ventricle cannot accept cannot accept enough blood enough blood decreased increased venous cardiac pressure; jugular output distension decreased blood pressure and shock

(removal of fluid from the sac with a needle) Question What is the immediate treatment for severe cardiac tamponade? Oxygen Cardiac drugs Surgery Pericardiocentesis (removal of fluid from the sac with a needle)

Answer Pericardiocentesis (removal of fluid from the sac with a needle) Rationale: In severe cardiac tamponade, there is so much fluid in the pericardial sac compressing the heart that its function declines rapidly. The fluid must be removed quickly by inserting a needle into the pericardial space and aspirating the accumulated fluid.

Pulsus Paradoxus On inhaling, the right ventricle fills with extra blood When the right ventricle is overfilled, the left ventricle is compressed and cannot accept much blood. Because the heart cannot fully expand On the next heartbeat, the left ventricle does not send out much blood: systolic BP drops

Coronary Heart Disease Atherosclerosis blocks coronary arteries Ischemia may cause: Angina Heart attack Cardiac arrhythmias Conduction deficits Heart failure Sudden death

Plaque/Thrombus Formation

Chronic Ischemic Heart Disease Imbalance in blood supply and the heart’s demands for oxygen Less blood Atherosclerosis Vasospasm Thrombosis Higher oxygen demand Stress Exercise Cold

Kinds of Angina Stable angina Pain when heart’s oxygen demand increases Variant angina Pain when coronary arteries spasm Silent myocardial ischemia Myocardial ischemia without pain

Acute Coronary Syndromes ECG changes T-wave inversion ST-segment depression or elevation Abnormal Q wave Serum cardiac markers Proteins released from necrotic heart cells Myoglobin, creatine kinase, troponin

Question Tell whether the following statement is true or false. Chronic ischemic heart disease is more likely to result in stable angina than acute coronary syndromes.

Answer True Rationale: Ischemic heart disease is characterized by stable angina, which is associated with plaques that are fixed obstructions. Unstable angina is characterized by plaques with platelets stuck to them (these are likely to form a thrombus)—they cause a range of acute coronary syndromes.

Acute Myocardial Infarction Chest pain Severe, crushing, constrictive, OR like heartburn Sympathetic nervous system response GI distress, nausea, vomiting Tachycardia and vasoconstriction Anxiety, restlessness, feeling of impending doom Hypotension and shock Weakness in arms and legs

An Acute MI (AMI) Leaves Behind an Area of Yellow Necrosis

Complications of AMI Heart failure Cardiogenic shock Pericarditis Thromboemboli Rupture of the heart Ventricular aneurysms

Malfunctioning Heart Muscle Malfunctioning heart muscle can cause heart failure if: Ventricles are unusually thick so there is not a normal amount of room for blood inside them (hypertrophic cardiomyopathy) Ventricles are too stiff to stretch (restrictive cardiomyopathy) Ventricles are too weak to pump out the blood that is in them (MI, myocarditis, dilated cardiomyopathy)

Myocardial Disorders Myocarditis Cardiomyopathies Dilated cardiomyopathies Hypertrophic cardiomyopathies Restrictive cardiomyopathies Peripartum cardiomyopathy

Hypertrophic Cardiomyopathy Defects in their contractile proteins make cells too weak They hypertrophy to do the same amount of work as normal cells Need more oxygen and perform less efficiently, so the person is prone to heart failure and may suffer sudden death during exertion

Question Which type of cardiomyopathy is characterized by weakened ventricles? Dilated cardiomyopathy Hypertrophic cardiomyopathy Restrictive cardiomyopathy Peripartum cardiomyopathy

Answer Dilated cardiomyopathy Rationale: In dilated cardiomyopathy, the ventricles are too weak to pump blood, resulting in a diminished cardiac output (CO). The other types listed are caused by thick ventricles, stiff ventricles, or LV dysfunction in late pregnancy or postpartum, respectively.

Valvular Disorders and Heart Defects By interfering with normal blood flow, these often cause the signs and symptoms of left- or right-sided heart failure body right left heart heart lungs

The Endocardial Structures The endocardial structures lining the heart can cause heart failure If the AV valves leading into the ventricles do not work (mitral or tricuspid problems) If the semilunar valves leading out of the ventricles do not work (aortic or pulmonary problems)

Arrange these steps in the proper order: Cardiac Cycle Discussion: Arrange these steps in the proper order: – Ventricles relax – First heart sound – Start Systole – Semilunar valves open – End Diastole – AV valves close – AV valves open – Semilunar valves close – Ventricles contract – Second heart sound 6 4 1 5 10 3 9 7 2 8

Valve Defects Each of the four valves can be defective Stenosis: valve will not open all the way; it is harder to force blood through it Regurgitation: valve will not close all the way; it leaks when it should be closed Also called valvular insufficiency

Question Tell whether the following statement is true or false. Mitral valve regurgitation results in a diminished stroke volume.

Answer True Rationale: If the mitral valve does not close as it should, a portion of the stroke volume (amount of blood ejected by the ventricle/beat) leaks back into the left atrium, decreasing the amount of blood that is ejected during that beat (SV).

Discussion Defects in which valves might cause: Severe dependent edema? Paroxysmal nocturnal dyspnea? Congested liver? Distended jugular veins? Productive cough with frothy sputum?

Identifying Defective Valves The blood going through the valve makes a noise These are called heart murmurs You can identify them by: Where they are—which valve are they near? How they sound—high- or low-pitched? When they happen—systole or diastole?

When Will You Hear Murmurs? If a valve is stenotic, you will hear a murmur of blood shooting through the narrow opening when the valve is open If a valve is regurgitant, you will hear a murmur of blood leaking back through when the valve should be closed

Left-sided Valvular Disorders Mitral valve disorders Mitral valve stenosis Mitral valve regurgitation Mitral valve prolapse Aortic valve disorders Aortic valve stenosis Aortic valve regurgitation

Valvular Disorders Mitral Regurgitation Aortic Valve Stenosis Part of SV goes back into the LA Heart has to work harder to meet body needs LV hypertrophy Aortic Valve Stenosis Aortic valve is constricted Difficult to pump blood from the LV LV hypertrophy Mitral Stenosis Incomplete LV filling Lower CO Aortic Regurgitation Blood flows backward into the LV from the Aorta LV Dilatation

Congenital Heart Defects Atrial septal defects Ventricular septal defects Endocardial cushion defects Patent ductus arteriosus Pulmonary stenosis Tetralogy of Fallot Transposition of the great vessels Coarctation of the aorta

Shunts A shunt is an opening or connection that lets blood move from one side of the circulation to the other Most shunts occur in the heart and move blood either from the left to the right or from the right to the left Because the left side is stronger, blood is usually pushed from the left to the right side

Shunts (cont.) Shunts are normal before birth Foramen ovale Lets blood go from the right atrium to the left atrium to bypass the lungs Ductus arteriosus Lets blood go from the pulmonary trunk to the aorta to bypass the lungs Ductus venosus Lets blood go from the visceral veins to the vena cava, bypassing the liver

body left right heart heart lungs Less blood goes to body Left-to-right Shunt Less blood goes to body body right left Blood moves from left to right heart heart More blood goes to lungs lungs

body left right heart heart lungs Deoxygenated blood goes to body Right-to-left Shunt Deoxygenated blood goes to body body right Blood moves from right to left left heart heart Less blood goes to lungs lungs

body left right heart heart lungs Discussion Show how the diagram would look for: Patent ductus arteriosus body right left heart heart lungs

body left right heart heart lungs Discussion Show how the diagram would look for: Transposition of the great vessels body right left heart heart lungs

body left right heart heart lungs Discussion Show how the diagram would look for: Tetralogy of Fallot body right left heart heart lungs