Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man.

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Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

Wnt pathway Ligands Receptors Intracellular components Transcription factors Interactome

Wnt “Wnt” is a combination of Wg (wingless) gene in Drosophila and Int gene in MMTV, two homologous genes Wnt are secreted proteins 19 Wnt genes in humans and mice

Wnt Receptors Receptor tyrosine kinase Derailed/RYK ROR Frizzled-transmembrane receptor LRP (lipoprotein-receptor related protein) Single-pass Tm proteins Cytoplasmic tail phosphorylated by GSK3 and CK1 

Wnt Pathway

Wnt signaling

Interactions: Intracellular Components

Intracellular Components

Canonical/Non-canonical Wnt pathway

Wnt Pathway Interactome

Wnt pathway interactions

Role of Wnt signaling

Development Neural development: CNS Neural crest Limb Tumor formation Cellular growth and proliferation

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