1. Responding to environmental signals Inter-cellular communication—driving cell division

2. JUXTACRINE

5. Anchorage dependence

8. Contact-dependence

9. P HIPPO signaling pathway

10. Paracrine (local) signaling through receptor tyrosine kinases (RTKs)

12. How does GF binding lead to mitosis?

14. Phosphorylation Cycle

18. Activation of a MAP Kinase- Kinase-Kinase (MAP-KKK) Transcription of genes that promote cell division Activation of a MAP Kinase- Kinase (MAP-KK) P Activation of a MAP Kinase- Kinase (MAPK) P Activation of a transcription factor P

20. GAP GEF

23. Receptor overexpression (frequent collisions/dimerization) hypersensitive to low levels of GF GF-independent signaling Receptor point mutation or deletion (constitutive signaling) Fusion protein (constitutive signaling) Activation of messenger protein

26. Paracrine signaling through non-tyrosine-kinase receptors

28. I NHIBIT CELL DIVISION

29. Sonic, Indian, Desert differentiation

32. wnt activated frizzled division

33. Autocrine Signaling

36. Juxtacrine Signaling

37. Juxtacrine signaling to promote division