Lymphatic System & Body Defenses Anatomy and Physiology II Mrs. Harborth
Lymphatic System Made of: Lymphatic vessels Lymphatic tissues and organs
Lymphatic Vessels Pick up excess fluid (lymph) in the tissues and returns it to bloodstream Flows only toward the heart Vessels lead to one of 2 large ducts Right lymphatic duct Thoracic duct
Lymph Nodes Remove foreign material from lymphatic stream and produce lymphocytes Most are kidney-shaped, less than an inch long Cortex Follicles Germinal Centers Plasma cells Medulla
Lymphoid Organs Lymph nodes Spleen Thymus gland Tonsils Peyer’s patches on intestines
Body Defenses Nonspecific vs Specific defense systems
Nonspecific Body Defenses Mechanical barriers Cells Chemicals
Cells and Chemicals Phagocytes phagocytosis animationphagocytosis animation Natural killer cells Inflammatory response leukocyte rolling animationleukocyte rolling animation Antimicrobial chemicals Complement Interferons interferon animationinterferon animation Fever Pyrogens Iron and zinc gathered by liver/spleen
Specific Body Defenses: Immune Response Functional system that recognizes foreign molecules (antigens) and inactivates or destroys them Humoral (antibody-mediated) or cellular (cell-mediated) Immunity 3 aspects of immune system: 1. Antigen specificity 2. Systemic 3. Has “memory”
Antigens Foreign proteins, nucleic acids, large carbs, some lipids Self-antigens Hapten (incomplete-antigen)
Lymphocytes Originate from hemocytoblasts in red bone marrow B cells become immunocompetent in bone marrow T cells become immunocompetent in the thymus Once immunocompetent, only reacts to one distinct antigen Genetic determinance
Macrophages Arise from monocytes in bone marrow Engulf foreign particles and present fragments of antigens on surfaces where T cells “read” them Monokines Killer macrophages Stay in lymphoid organ
Humoral Immune Response B Lymphocytes undergo clonal selection Plasma cells (antibody levels peak at 10 days) Memory cells
Active Immunity B cells encounter antigens and produce antibodies Naturally acquired or artificially acquired
Passive Immunity Antibodies come from outside source (animal or human) Fetal circulation or immune serum Monoclonal antibodies
Antibodies IgM, IgA, IgD, IgG, IgE Complement fixation Neutralization Agglutination Precipitation
Cellular Immune Response Antigen presentation (macrophages and T cells) Interleukin 1 Helper T cells, Cytotoxic T cells, Suppresor T cells, Delayed hypersensitivity T cells, memory cells
Organ Transplantation/Rejection Autografts Isografts Allografts Xenografts
Allergies Immediate hypersensitivity Delayed hypersensitivities
Immunodeficiencies SCID AIDS
Autoimmune Diseases MS Myasthenia gravis Grave’s disease Juvenile diabetes mellitus Systemic lupus erythematosus Glomerulonephritis Rheumatoid Arthritis