1 William K. Barnett, Indiana University Indiana CTSI The HUBzero ™ Collaborative Infrastructure and Biomedical Research

2 Agenda The Changing Nature of Scholarly Research Overview of the HUBzero Platform Institutional HUB: The Indiana CTSI Project HUB: Cancer Care Engineering

3 The Changing Nature of Scholarly Research

4 Research intellectual capital is distributed. Collaborative research is increasingly becoming the norm. Translational research depends on interdisciplinary or transdisciplinary (the resulting focus is something new) teams. The resources necessary for competitive research are no longer found in any one research lab. Distributed facilities and data are changing the research resource landscape.

5 Team Science and Virtual Organizations Team Science is a higher risk, higher reward approach to research. Types of Collaborations include: Social Networking Knowledge Networking Resource Networking With the current suite of Web 2.0 tools, it inevitably involves virtual collaboration and the creation of virtual organizations. Includes ‘traditional’ collaboration tools of telephones and conference calls, , and teleconferencing. (Noshir Contractor, presentation at the 2010 VIVO Conference, Queens, NY)

6 Issues in Team Science and Virtual Organizations Persistence beyond face to face relationships requires: Motivations and Rewards Trust Dealing with cultural differences Governance and Management Shared Infrastructures and resource management Metrics and Assessment Sustainability – financial, intellectual, infrastructure “Building Effective Virtual Organizations” (NSF) and “Collaboration & Team Science: A Field Guide” (NIH)

7 Different Styles of Virtual Organizations Highly distributed communities of independent scholars whoshare educational content and tools (NanoHUB). Institutional collaborations that accelerate research workflows(Open Science Grid, Indiana CTSI HUB). HUBs that accelerate distributed research projects (cceHUB).

8 Overview of the HUBzero Platform

9 History of HUBzero Feb 2007: 1 hub Feb 2008: 5 hubs Feb 2009: 8 hubs Today: 30 hubs Each hub has its own funding stream Outside institutions: EPA, NYSTAR, Rice

10 What is a Hub? nanoHUB.org Different than a Web Portal: It supports computational tools Ties seamlessly to HPC backends It supports multimedia content Publishable references User Profiles and Private groups Basic Features: Interactive Simulation Tools Online Presentations Mechanism for Uploading New Resources Tool Development Area Ratings and Citations Content Tagging Wikis and Blogs User Groups for Private Collaboration User Support Area Usage Metrics News and Events Feedback mechanisms

11 Scalability and Usage Metrics 161,142 users worldwide As much traffic as Users at all Top 50 US Engr Schools 19% of all.edu domains 116 classes at 97 institutions in ,800 users ran 348,000 simulations nanoHUB.org users

12 Other Hubs 32,107 users worldwide 9,433 users worldwide3,609 users worldwide 2,433 users worldwide1,431 users worldwide

13 Demonstrate Your Own Impact

14 Educational Use Is Growing 116 classes at 97 institutions in 2009 nanoHUB.org Educational Usage

15 Uploading Resources Research Education Tools Supporting ResourcesTags Reviews Demo >>

16 Rappture: Rapid Application Infrastructure Scientist Works with your favorite programming language Open Source Online at Used by 200 projects and 300 developers Rappture = Simulation Code

17 Hundreds of tools online!

18 Cyberinfrastructure for Running Tools Physical Machine Virtual Machine Content Database Rendering Farm Maxwell’s Daemon Middleware tool session cluster nanowire job nanoVIS Linux/Apache/MySQL/PHP

19 Start Your Own Hub! Debian GNU/Linux bit HUB-in-a-box: VMware images Open Source Release: LGPL v3 license At HUBzero.org: Downloads Documentation Make Wishes

20 HUBzero Consortium hubzero.org Four founding members provide financial and governance sustainability Ongoing development of HUBzero core Yearly conference: HUBbub

21 New Features for 2011 Moodle Integration Multifaceted Identity Management (via Shibboleth, ADS, Google) User groups with fine grained authorization and document management Integration with Fedora repositories Scientific workflows via Pegasus Workflow Management System Wiki template pages and new wiki macros Blogs for personal profiles and groups Support for MATLAB Parallel Toolbox job submission Direct Condor job submission Access control layer for support tickets Completely new and improved search engine with plug-ins Auto-completer for tags, members, groups Twitter feed module Contributed by Projects and Community and Consortia members

22 Institutional HUB: the Indiana CTSI

23 Projects: The Indiana CTSI HUB Statewide multi-institutional initiative ‘Translation’ of research from basic to pre-clinical to clinical research, ultimately to improve health care. Focus on research process improvement (funding, collaboration, research administration) Includes community organization and industry partnership tools

24 Indiana CTSI HUB Tools Federated Identity Support for ease of use and improved trust for sensitive data Ontology-based tagging of HUB content with the National Center for Biomedical Ontology Grant Management (based on Open Journal System) Alfresco Share – file sharing among distributed teams (Open Source) 500 Users and 5 GB of documents REDCap – web based data collection and management (Vanderbilt) 175 Users and 110 Projects. i2iconnect.org – Technology transfer matchmaking 914 Listings CTSA2Community.org - a repository of best practices for community engaged research

25 Future Directions VIVO and many CTSAs are creating a national faculty profiling architecture and applications for research networking, competitive intelligence, etc. See demonstration at direct2experts.org CTSAs are working with Eagle-I, RDS, biositemaps, BRO, NIF, etc to create a national resource networking architecture to manage facilities, repositories, etc. and applications like ‘core marketplaces’ that can leverage them. The Booz Allen Hamilton RFA to 1) create Linked Open Data repositories and 2) develop applications that leverage LOD for translational research.

26 Some Other Translational Research Platforms Harvard Catalyst (Harvard) and Profiles (UCSF and Minnesota) VIVO (Cornell and Florida) Loki (Iowa) Community Academic Profiles (Stanford) Digital Vitae (Pittsburgh) CTSA Sharecenter (Oregon and UCSF) SciVal (Elsevier at a number of institutions)

27 Project HUB: Cancer Care Engineering

28 Projects: The Cancer Care Engineering HUB Single portal integrates clinical and analytical data collection and analysis across 6 geographically distributed teams Includes tools for: sample tracking, data browsing, instrument data collection, modeling, visual analytics Sample Collection Clinical Patient Data Laboratory Analysis Visual Analytics Predictive Modeling

29 Thank You Questions?