© The Children’s Hospital of Philadelphia. Proprietary and confidential. Do not copy. The Effects of Secondhand Smoke in the Lung - Hyperpolarized Helium Diffusion MRI Chengbo Wang, PhD 1, T. A. Altes, MD 1,2, G. W. Miller, PhD 2, E. E. de Lange, MD 2, K. Ruppert, PhD 1,2, J. F. Mata, PhD 2, G. D. Cates, Jr, PhD 3, J. P. Mugler, III, PhD 2,4 1 Radiology, The Children’s Hospital of Philadelphia, Philadelphia, PA 2 Radiology, 3 Physics, 4 Biomedical Engineering, University of Virginia, Charlottesville, VA
Active Cigarette Smoking 15-30% of smokers develop chronic obstructive pulmonary disease (COPD) High morbidity & mortality 4 th leading cause of death 30 Million (10%) Americans have COPD (estimated) Total estimated cost: $32 Billion for the US in 2002
Secondhand cigarette smoking Causes coronary heart disease and lung cancer Evidence suggests but not sufficient to prove secondhand smoke causes COPD before our study The 2006 U.S. Surgeon General's Report on The Health Consequences of Involuntary Exposure to Tobacco Smoke
Methods to diagnose COPD Patient shortness of breath × not sensitive Pulmonary function test × not sensitive CT × radiation exposure Helium MRI (New Technique) √ none radiation exposure
Hyperpolarized Helium MRI Conventional MRI Helium MRI
Helium Diffusion MRI Measures apparent diffusion coefficient (ADC) ADC reflects the alveolar size Emphysema Normal alveoli Normal ADC Healthy Enlarged alveoli Elevated ADC COPD
ADC maps Healthy 55 yrs COPD (Gold stage 0) 70 yrs Normal ADC Normal alveoli Elevated ADC Enlarged Alveoli Red - > small ADC values -> good Yellow -> large ADC values -> bad
Purpose Determine whether Helium diffusion MRI detects the effects of secondhand smoke in the lungs
Subjects 60 total subjects 23 low exposure to secondhand smoke Negative control group 10 M, 13 F; age: yrs 22 high exposure to secondhand smoke 3 M, 19 F; age: yrs 15 past or active smokers Positive control group 4 M, 11 F; age: yrs
Results: ADC 67% 33%73% 27% 96% 4% P=0.047 P<0.001 (n=23)(n=22)(n=15) Elevated Normal
Results: ADC Normal ADC Normal alveoli Highly elevated ADC Enlarged Alveoli Elevated ADC Enlarged Alveoli?? Early emphysema?? cm 2 /s Red - > small ADC values -> good Yellow -> large ADC values -> bad
Summary An increased ADC has been found in: 67% of the smokers 27% of the subjects with high exposure 4% of subjects with low exposure This finding may reflect a response to smoking
Conclusions Helium diffusion MRI detects elevated ADC in subjects with high exposure to secondhand smoke Elevated ADC may reflect lung structural damage or subclinical emphysema Helium diffusion MRI may be more sensitive than other methods to detect mild emphysematous changes
Acknowledgments CHOP Talissa A Altes, MD Kai Ruppert, PhD Yulin Chang, PhD UVA John P Mugler, III, PhD Eduard E de Lange, MD James R Brookeman, PhD G Wilson Miller, PhD Jaime Mata, PhD Gordon D Cates, Jr, PhD Mike Salerno, MD, PhD Jing Cai, PhD John M Christopher, RT Doris A Harding, RN Joanne Gersbach, RN Funding NHLBI: RO1- HL Flight Attendant Medical Research Institute Commonwealth of Virginia Technology Research Fund Siemens Medical Solutions
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