Alzheimer’s Disease By Juan Escobar Per: 4

Alzheimer’s Disease  A common form of dementia of unknown cause, usually beginning in late middle age, characterized by memory lapse, confusion, emotional instability, and progressive loss of mental ability.

Associated Features  A type of Dementia  Language Disturbance  Impaired ability to carry out motor activities  Failure to recognize or identify objects  Disturbance in Executive functioning, such as planning, organizing, or abstracting.

Associated Features  DSM-IV-TR Diagnostic Criteria for Dementia of Alzheimer’s Type A. The development of multiple cognitive deficits manifested by both (1) memory impairment (impaired ability to learn new information or to recall previously learned information) (2) one (or more) of the following cognitive disturbances: (a) aphasia (language disturbance) (b) apraxia (impaired ability to carry out motor activities despite intact motor function)

Associated Features (c) agnosia (failure to recognize or identify objects despite intact sensory function) (d) disturbance in executive functioning (i.e., planning, organizing, sequencing, abstracting) B. The cognitive deficits in Criteria A1 and A2 each cause significant impairment in social or occupational functioning and represent a significant decline from a previous level of functioning. C. The course is characterized by gradual onset and continuing cognitive decline. D. The cognitive deficits in Criteria A1 and A2 are not due to any of the following:

Associated Features (1) other central nervous system conditions that cause progressive deficits in memory and cognition (e.g., cerebrovascular disease, Parkinson's disease, Huntington's disease, subdural hematoma, normal-pressure hydrocephalus, brain tumor) (2) systemic conditions that are known to cause dementia (e.g., hypothyroidism, vitamin B or folic acid deficiency, niacin deficiency, hypercalcemia, neurosyphilis, HIV infection) (3) substance-induced conditions E. The deficits do not occur exclusively during the course of a delirium. F. The disturbance is not better accounted for by another Axis I disorder (e.g., Major Depressive Episode, Schizophrenia). Code based on presence or absence of a clinically significant behavioral disturbance:

Associated Features Without Behavioral Disturbance: if the cognitive disturbance is not accompanied by any clinically significant behavioral disturbance With Behavioral Disturbance: if the cognitive disturbance is accompanied by a clinically significant behavioral disturbance. (e.g., wandering, agitation) Specify subtype: With Early Onset: if onset is at age 65 years or below With Late Onset: if onset is after age 65 years

Etiology  Genetics  According to the Alzheimer's Association, genetic links are either strong or weak.  Between 5 and 10 percent of persons with Alzheimer's have a strong family history of early-onset Alzheimer's. In these cases having a specific gene essentially determines you will develop Alzheimer's.  For late-onset Alzheimer's, having one of three genes is associated with an increased risk of developing the disease. However, not everyone with one of these genes will get Alzheimer's and many who develop Alzheimer's have none of these genes.

Prevalence  The Prevalence of Dementia of the Alzheimer’s type increases dramatically with increasing age, rising from 0.6% in males and 0.8% in females at age 65 (All levels of severity).  To 11% in males and 14% in females at age 85  At age 90 the prevalence rises to 21% in males and 25% in females, and by age 95 the prevalence is 36% in males and 41% in females.  Moderate to severe cases make up about 40%-60% of these estimated prevalence rates.

Treatment  There is no cure for Alzheimer’s Disease.  Slow down the progression of AD, but is difficult to do.  Medicines can be used to slow down progression, but symptoms worsen.  Small change after using medicine.

Prognosis  Six stages of Alzheimer’s disease: 1.Forgetfulness 2.Early Confusional 3.Late Confusional 4.Early Dementia 5.Middle Dementia 6.Late Dementia  If you don’t get treatment in the early stages of dementia the brain becomes irreversible.  The more widespread structural damage to the brain, the lower the chances the person with dementia will ever regain lost functions.

References  Acuff, K. (2010). Etiology of alzheimer’s disease. Retrieved from disease/  American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders: DSM-IV-TR. Washington, DC  Halgin, R.P. & Whitbourne, S.K. (2005). Abnormal psychology: clinical perspectives on psychological disorders. New York, NY: McGraw- Hill.  Myers, D.G. (2011). Myers psychology for ap. New York, NY: Worth Publishers.

Discussion Questions  Do you know someone who you think might have Alzheimer’s Disease? If yes Why?