L4 TB4 L7TB7 G1P3interferon, alpha-inducible protein (clone IFI-6-16) GZMAgranzyme A GZMBHuman serine protease-like protein mRNA, complete cds. DPTdermatopontin.

Slides:

Advertisements

Similar presentations

Cytokines 1. Introduction of cytokines 2. Classification of cytokines

Advertisements

PRINCIPLES OF INNATE IMMUNITY

Structure of T Cell Receptor CHO Variable region “V” Constant region “C” Hinge “H ” Alpha chain Beta chain Disulfide bridge Transmembrane region Cytoplasmic.

Principles of Immunology The Inflammatory Process 4/6/06 "Life is not measured by the number of breaths we take, but by those special moments that take.

Functions Receptors Signaling Chapter 11

IGF in circulation The majority (> 75 %) exists as bound form –IGF binding proteins (IGFBPs) IGFBPs –6 proteins and several related proteins –Serum IGFBP.

Cytokines Prof. Dr. Zahid Shakoor M.B.B.S, Ph D (London)

Chapter 8 Cell Adhesion Molecules (CAM)

Books Molecular Cell Biology Lodish

SHC p13.3 SHC (Src homology 2 domain containing) transforming protein 2 CDC p13.3cell division cycle 34 GZMM p13.3granzyme M.

L4 L7 TB4 TB7 Regulation of Genes Relevant to General Immune Response C6Complement component 6, facilitates clearance of antigen-antibody complexes C1RComplement.

hypothetical protein LOC554226LOC _at neurotrophic tyrosine kinase, receptor, type 3NTRK _s_at nuclear receptor.

CYTOKINE RECEPTORS AND SIGNAL TRANSDUCTION. Survival factor (eg. IGF-1) ChemokinesHormonesTransmitters (e.g. Interleukins serotonin etc.) Growth factors.

Gene SymbolGene Name Fold Difference 1 q-value (%) 2 NL BM? 3 NR2F1nuclear receptor subfamily 2, group F, member No SLC2A10solute carrier family.

A b Cell Cycle c Proliferation KINASE A ANCHOR PROTEIN CASPASE 3, APOPTOSIS-RELATED CYSTEINE PROTEASE NUCLEAR RECEPTOR SUBFAMILY 3, GROUP C, MEMBER 1 BRUTON’S.

Immune System Overview. GOT DEFENSE? ANATOMY OF THE IMMUNE SYSTEM The immune system is localized in several parts of the body –immune cells develop.

Chapter 7 Leukocyte differentiation antigen and cell adhesion molecules Cell membrane molecules: Antigen, receptor, others Cell surface marker.

LDA and Adhesion molecule

T CELL MEDIATED IMMUNITY (Cell Mediated Immunity).

Probe set Gene SymbolGene TitleRefSeq Transcript IDp-value Fold- Change _atIL7Rinterleukin 7 receptorNM_ _atCD28CD28 molecule.

Craig D. Woodworth, Evan Michael, Laura Smith, and Matthias Nees. Department of Biology, Clarkson University, Potsdam, NY, USA, and Department of Pediatric.

Immunology Chapter 11 Richard L. Myers, Ph.D. Department of Biology Southwest Missouri State Temple Hall 227 Telephone:

1 Chapter 7 CAM & LDA Department of Immunology Xing-cheng WEI ( 韦星呈 ) Building of Basic Medicine Room 323 Tel (office)

TCR ( seen here in a ternary complex …) TCR’s come in two flavors…

NC-1 NC-2 NC-3 NC-4 NC-5 NC-6 NC-7 NC-8 NC-9 NC-10 NC-11 IN-1 IN-2 IN-3 IN-4 IN-5 IN-7 IN-8 IN-11 IN-12 IN-14 IN-16 AS-1 AS-7 AS-20 AS-21 AS-29 AS-32 AS-33.

Chapter 15- Cell Communication Part I- General signaling strategies

Cytokines are a diverse group of non- antibody proteins released by cells that act as intercellular mediators, especially in immune processes.

Specific Defenses of the Host Part 2 (acquired or adaptive immunity)

Supplementary table 2. Genes upregulated in both microarray and RNA-seq analysis Gene IDGene SymbolGenBank accesion no.Microarray FCP.ValueRNA-seq FCTM/SP.

5. Cytokine 细胞因子王家鑫，孟明 Department of Veterinary Immunology College of Animal Science and Technology Agricultural University of Hebei.

Table S10. A set of 140 Genes differentiating DF vs DHF (HG-U133 plus2 platform) Probeset IDGene SymbolGene Title p-value(DF vs. DHF) Fold- Change(DF vs.

Interferons Induction of synthesis Induction of antiviral activity Antiviral activities induced by interferons  and  Antiviral activities induced by.

Figure S9. 65 genes classifying early and late acute and convalescent phases on HG-focus platform* Gene symbolGene title p value (Phases) Fold change (early.

Probeset IDGene SymbolGene Titlep-valueFold-Change _atIFI27interferon, alpha-inducible protein E _atCXCL10chemokine (C-X-C.

Table S4. List of genes significantly changed in late acute phase vs convalescent phase (HG-focus platform) Probeset IDGene SymbolGene Titlep-valueFold-Change.

Date of download: 6/23/2016 From: Glucocorticoid Therapy for Immune-Mediated Diseases: Basic and Clinical Correlates Ann Intern Med. 1993;119(12):

Supp table 1: Gene sets differentially expressed in Angpt-1 high MDS samples No.Gene Set NameGenes 1KEGG_CELL_CYCLE cyclin-dependent kinase 1, E2F transcription.

Chapter 43 The Immune System.

Chapter 7. 주조직적합성 복합체 1. 주조직적합성 복합체 (MHC)의 발견 2. MHC 분자의 구조

Introduction to Receptors

Immune Receptors and Signal Transduction

By uzair hashmi Interferon.

Recognition of Antigen By T cells: The TCR

T cells I. T cell maturation in the thymus II

This diagram outlines the key mechanisms by which calcineurin (Cn) inhibitors and mammalian target of rapamycin (mTOR) inhibitors inhibit T-cell activation.

OVERVIEW: Signals for cell surface receptors (hydrophilic):

Major Histocompatibility Complex

Supplementary Table. Gene expression profiling reveals a decrease in NFkB-driven gene signature pattern upon treatment with MLN4924. Gene ID Name Treated/

Principles of Immunology Cytokines

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

بيولوژي لنفوسيتهايT لنفوسيتهاي T نقش اساسي و محوري در پاسخ به آنتي ژنهاي پروتئيني دارند و به دليل وجود پروتئين در اكثر ارگانيسم هاي عفونت زا سلولهاي.

The role of viruses in acute exacerbations of asthma

Cells into Tissues By Kevin Huyen.

*** *** Supplemental figure NR4As/ cyclophilin mRNA 0.6

Figure 1 Activation and signalling of IL-1

Cytokines and Chemokines Chapter 6

The major histocompatibility complex (MHC) and MHC molecules

INTERLEUKIN 10 (IL-10) CATEGORY: RECEPTORS & MOLECULES

Nat. Rev. Rheumatol. doi: /nrrheum

Jo-Ellen Murphy, Caroline Robert, Thomas S. Kupper

Pro-endometriotic niche in endometriosis

T cell receptor complex and diversity

Combination extract inhibits immune responses in vivo.

Schematic summary of the mechanisms by which tick-borne Phlebovirus NSs proteins inhibit the canonical IFN induction and signaling pathways. Schematic.

Simplified diagrammatic representation of a selection of mechanisms of glomerular injury. Simplified diagrammatic representation of a selection of mechanisms.

Figure 1. Cross talk between the immune system and osteoclasts in osteoclastogenesis. Osteoclasts are derived from monocyte precursor cells. RANKL from.

Wolbachia-induced responses of specific cell types.

Differential pathway regulation in advanced idiopathic pulmonary fibrosis (IPF) lung. a) Metacore analyses of pathway enrichment in IPF versus control.

Presentation transcript:

L4 TB4 L7TB7 G1P3interferon, alpha-inducible protein (clone IFI-6-16) GZMAgranzyme A GZMBHuman serine protease-like protein mRNA, complete cds. DPTdermatopontin CES1carboxylesterase 1 (monocyte/macrophage serine esterase 1) ITGBL1integrin, beta-like 1 (with EGF-like repeat domains) C6complement component 6 C1Rcomplement component 1, r subcomponent ITGA2Bintegrin, alpha 2b CD59CD59 antigen p18-20 SDC2syndecan 2 HSPA2Human heat shock protein HSPA2 gene, complete cds. LTB4DHleukotriene B4 12-hydroxydehydrogenase C7complement component 7 CXCL12chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) TNFSF11tumor necrosis factor (ligand) superfamily, member 11 CXCL12chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) HLA-DOBmajor histocompatibility complex, class II, DO beta TNFRSF6tumor necrosis factor receptor superfamily, member 6 C1Rcomplement component 1, r subcomponent HLA-Amajor histocompatibility complex, class I, A HLA-Cmajor histocompatibility complex, class I, C EBI2Epstein-Barr virus induced gene 2 IL2RBinterleukin 2 receptor, beta DAFdecay accelerating factor for complement LNKlymphocyte adaptor protein SP110SP110 nuclear body protein IL15interleukin 15 KLRC1killer cell lectin-like receptor subfamily C, member 1 IFIT1interferon-induced protein with tetratricopeptide repeats 1 IL8interleukin 8 CXCR6chemokine (C-X-C motif) receptor 6 TNFSF5tumor necrosis factor (ligand) superfamily, member 5 KIR3DL2killer cell immunoglobulin-like receptor IL8interleukin 8 HERPUD1homocysteine-inducible, endoplasmic reticulum stress-inducible CCL3chemokine (C-C motif) ligand 3 PSMA1proteasome (prosome, macropain) subunit, alpha type, 1 IFNGR1interferon gamma receptor 1 AOAHacyloxyacyl hydrolase (neutrophil) TNFSF6tumor necrosis factor (ligand) superfamily, member 6 LAKlymphocyte alpha-kinase C3AR1complement component 3a receptor 1 KLRC4killer cell lectin-like receptor subfamily C, member 4 IFI16interferon, gamma-inducible protein 16 TNFSF4tumor necrosis factor (ligand) superfamily, member 4 IL1RAPinterleukin 1 receptor accessory protein CSF2RBcolony stimulating factor 2 receptor KLRC3killer cell lectin-like receptor subfamily C, member 3 MNDAmyeloid cell nuclear differentiation antigen PDE4Bphosphodiesterase 4B, cAMP-specific KLRD1killer cell lectin-like receptor subfamily D, member 1 KIR2DL3killer cell immunoglobulin-like receptor CD7Human CD7 antigen gene, exons 1-4. CD80CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) LY75lymphocyte antigen 75 (1)

CD84CD84 antigen (leukocyte antigen) TNFSF7tumor necrosis factor (ligand) superfamily, member 7 CD44Human cell surface glycoprotein CD44 (CD44) gene, exon 6. IRF2interferon regulatory factor 2 NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 CALRcalreticulin JAK1Janus kinase 1 (a protein tyrosine kinase) HSP89-alphaHomo sapiens heat shock protein (HSP89-alpha) gene, complete cds. ICAP-1Aintegrin cytoplasmic domain-associated protein 1 CCL5chemokine (C-C motif) ligand 5 NKG2-DHomo sapiens type II integral membrane protein (NKG2-D) gene FASTKFAST kinase IFRD2interferon-related developmental regulator 2 SERPINH1serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47) CCL28chemokine (C-C motif) ligand 28 ITGB1Human beta 1 integrin isoform C (ITGB1) gene, exon C. PKRdouble stranded RNA activated protein kinase (PKR) gene, intron 4. IFNARHuman IFNAR gene for interferon alpha/beta receptor. CD47CD47 antigen IL5RAinterleukin 5 receptor, alpha MMP15matrix metalloproteinase 15 (membrane-inserted) MMP25matrix metalloproteinase 25 ITGALintegrin, alpha L PECAM-1platelet/endothelial cell adhesion molecule-1 JAK3Janus kinase 3 (a protein tyrosine kinase, leukocyte) TNFSF14tumor necrosis factor (ligand) superfamily, member 14 LILRB1leukocyte immunoglobulin-like receptor, subfamily B IFNAR2interferon (alpha, beta and omega) receptor 2 AOC3amine oxidase, copper containing 3 (vascular adhesion protein 1) SELEselectin E (endothelial adhesion molecule 1) MMP2matrix metalloproteinase 2 CCL11chemokine (C-C motif) ligand 11 ITGB3BPintegrin beta 3 binding protein (beta3-endonexin) MX1myxovirus (influenza virus) resistance 1 PTX3pentaxin-related gene, rapidly induced by IL-1 beta HSPA9Bheat shock 70kDa protein 9B (mortalin-2) CXCL11chemokine (C-X-C motif) ligand 11 MMP9matrix metalloproteinase 9 IFNGinterferon, gamma LILRB2leukocyte immunoglobulin-like receptor TCF3transcription factor 3 IFITM1interferon induced transmembrane protein 1 (9-27) IL13interleukin 13 IL3interleukin 3 (colony-stimulating factor, multiple) CMKBR3Eosinophil eotaxin receptor (CMKBR3) gene c-fmsMacrophage colony stimulating factor receptor (c-fms) gene PTPN7protein tyrosine phosphatase, non-receptor type 7 IL2RAinterleukin 2 receptor, alpha TNFRSF17tumor necrosis factor receptor superfamily, member 17 MRC1Human macrophage mannose receptor (MRC1) gene, exon 24. CXCR3chemokine (C-X-C motif) receptor 3 ICAM2intercellular adhesion molecule 2 IRF7interferon regulatory factor 7 IFITM2interferon induced transmembrane protein 2 (1-8D) IFITM3interferon induced transmembrane protein 3 (1-8U) TGFB3transforming growth factor, beta 3 TRAP1heat shock protein 75 HLA-DQA1major histocompatibility complex, class II, DQ alpha 1 MMP7matrix metalloproteinase 7 (matrilysin, uterine) L4 TB4 L7 TB7 (2)