Dear colleagues, It is our pleasure to invite you to participate in the training workshop entitled “Functional analysis of CNS-infiltrating cells during the development of CNS autoimmunity, injury and repair” to be held in Athens, Greece between Tuesday, December 4th and Friday, December 7th This workshop is organized and funded within the framework of the EU 7th Framework Program Capacities project “NeuroSign” granted to three neuroscience laboratories of the HPI headed by Socrates Tzartos (co- ordinator), Rebecca Matsas and Lesley Probert. The program of this workshop has been prepared in order to span the state- of-the-art knowledge in the development of neuroimmune pathologies of the central nervous system together with hands-on practicals in current investigative techniques. Lectures are to be delivered by an international cast of leading experts in neuroimmunology and related fields. The aim is to promote and encourage awareness in the field and cooperation amongst aspiring and established neuroimmunologists. The workshop is open to young scientists at every level upon registration without fees and offers the opportunity to a limited number of highly motivated students to participate in afternoon practical sessions. Attendees are also welcome to present their work as a poster. For participation a completed registration form and required documents should be sent to Vivian Tseveleki We look forward to sharing this course with you in Athens, Greece. The organization team MARIA EVANGELIDOU IOANNIS GRIVAS MARIA KARAMITA VASILIKI KYRARGYRI IMPORTANT DATES LESLEY PROBERT Registration deadline: 20 th October VIVIAN TSEVELEKI WORKSHOP PROGRAM All plenary sessions will be held at the Auditorium of Hellenic Pasteur Institute, Building 8, Program of Practical sessions will be announced 1 st DAY, 4 December, Tuesday BASIC & CLINICAL ASPECTS OF IMMUNE-MEDIATED CNS DISEASE 09:00-09:30REGISTRATION (Auditorium, Building 8) 09:30-09:40WELCOME- OPENING REMARKS: Socrates Tzartos, Co- ordinator of “Neurosign”, Hellenic Pasteur Institute 09:40-10:25PLENARY SESSION- Chairs: L. Probert & C. Linington Christopher Linington, University of Glasgow Experimental autoimmune encephalomyelitis: a valid model for multiple sclerosis? 10:25-11:10Hans Lassmann, University of Vienna How to translate mechanisms from basic experimental studies to human multiple sclerosis 11:10-11:40Coffee Break with Posters 11:40-12:25David Baker, Barts and The London School of Medicine and Dentistry Use and abuse of animal models of multiple sclerosis 12:25-13:30Lunch Break 13:30-14:30AFTERNOON PRACTICAL SESSION- ALL PRACTICAL GROUPS Hallmarks of neuropathology- interactive demonstration Hans Lassmann 14:30-18:304 ROTATING GROUPS GROUP 1: EAE: induction and evaluation- Nadia Kavrochorianou GROUP 2:, Neuropathological analysis- Maria Karamita GROUP 3: Isolation and analysis of spinal cord infiltrates- Vivian Tseveleki & Ioannis Kanistras GROUP 4: Ex vivo T-cell imaging- Maria Evangelidou & Ioannis Grivas

4 th DAY, 7 December 2012, Friday THERAPEUTIC APPROACHES 09:30-10:15PLENARY SESSION- Chair: N. Grigoriadis & A. Uccelli Vivian Tseveleki, Hellenic Pasteur Institute, Athens Reestablishing immune tolerance for multiple sclerosis therapy 10:15-11:00Antonio Uccelli, University of Genoa Mesenchymal stem cells: Basics and therapeutic potential for multiple sclerosis 11:00-11:30Coffee Break with Posters 11:30-12:15Nikolaos Grigoriadis, Aristotle University of Thessaloniki Stem cells as therapies for multiple sclerosis: Are we ready for clinical trials? 12:15-13:00Krysztof Selmaj, Medical University of Lodz Immune intervention leading to progress in multiple sclerosis therapy 13:00-13:30CLOSING REMARKS, Workshop Photo 13:30-14:30Lunch Break 14:30-18:30AFTERNOON PRACTICAL SESSION- 4 ROTATING GROUPS 2 nd DAY, 5 December 2012, Wednesday CNS INFILTRATING CELLS 09:30-10:15PLENARY SESSION- Chairs: R. Liblau & V. Tseveleki Roland Liblau, Centre de Physiopathologie de Toulouse- Purpan T cells and CNS autoimmunity 10:15-11:00Edgar Meinl, Max Planck-Institute of Neurobiology, Munich B cells and CNS autoimmunity 11:00-11:30Coffee Break with Posters 11:30-12:15George Kollias, Biomedical Sciences Research Centre “Alexander Fleming”, Vari Endothelial pathways in the regulation of CNS autoimmunity and repair 12:15-13:30Lunch Break 13:30-17:30AFTERNOON PRACTICAL SESSION- 4 ROTATING GROUPS 3 rd DAY, 6 December 2012, Thursday PATHOGENIC MECHANISMS IN NEUROINFLAMMATION 09:30-10:15PLENARY SESSION- Chairs: R. Furlan & H. Wekerle Hartmut Wekerle Max Planck-Institute of Neurobiology, Munich In vivo imaging of Immune-CNS cell interactions 10:15-11:00Maria Evangelidou, Hellenic Pasteur Institute, Athens T cell - neuron interactions in the CNS 11:00-11:30Coffee Break with Posters 11:30-12:15Roberto Furlan, San Rafaele Scientific Institute, Milan Propagation of neuroinflammation by extracellular membrane vesicles 12:15-13:30Lunch Break 13:30-17:30AFTERNOON PRACTICAL SESSION- 4 ROTATING GROUPS

GENERAL INFORMATION Venue and Date: Hellenic Pasteur Institute Auditorium- Building 8, 127 Vassilissis Sofias Av., Ambelokipi, Athens 4-7 December 2012 Course language: The official language is English. No simultaneous translation will be provided Attendance certificates will be offered to every participant. Access: Hellenic Pasteur Institute (HPI) is situated in close proximity to the Athens city centre. Its main entrance is 127, Vassilissis Sofias Avenue. It is easily accessible by frequent direct buses (X95) and underground- Metro (blue line, No 3) from the Airport “El. Venizelos”. The closest bus stop to the Institute is “Ampelokipi” and Metro stations are “Megaro Moussikis” (front gate) or “Ambelokipi” (back gate). Further information: V. Tseveleki (Sc. Program) V. Staikou (NeuroSign Program Manager) Front Gate Back Gate