Dr. S. Finch MD,CM, FRCPC, ABAM-Diplomate
BPD is common disorder, especially in clinical populations Prevalence 1-2% general population, up to 10-20% outpatients, 25% agitated emergency patients BPD often present in crisis, suicidal and often in ED Challenging to work with
Diagnosis engenders strong reactions Over diagnosed and under diagnosed Black and white approach to treatment Patient’s concerns may be dismissed, suicide risk minimized and negative outcomes blamed on patient
Most literature based on intensive outpatient treatments Crisis management strategies usually end with transfer to ED Today’s discussion, 3 parts: Diagnosis and recognition of BPD Crisis presentations Strategies to treat BPD in crisis
DSM-IV-TR defines a PD as: “enduring subjective experiences and behaviour that deviate from cultural standards, are rigidly pervasive, have an onset in adolescence or early adulthood, are stable through time and lead to unhappiness and impairment.”
Borderline between psychosis and neurosis characterized by extremely unstable affect, behaviour, mood, self-image and object relations ICD-10: emotionally unstable PD “as-if” personality
Abandonment Stormy relationships Identity disturbance Impulsivity Chronic suicidality Mood reactivity Emptiness Anger/rage Paranoia/dissociation
Negative counter transference reaction Manipulation Self-sabotage Help-seeking, help-rejecting pattern Transitional objects, “teddy bear” sign
Just a negative reaction to a patient A cross-sectional diagnosis A hopeless case
more commonly have childhood histories of physical and sexual abuse, neglect, and early parental loss and separation Frequently co-morbid with other PDs Axis 1: mood disorders, PTSD, SUDs, eating disorders, ADHD, panic disorder, dissociative disorders
Unknown Multifactorial heterogeneous Genetic/neuroanatomy Amygdala/limbic system Serotonin 5HTT transporter gene Heritability inconsistent Dimensional, genetic phenotypes Livesley – four factor model Developmental Kernberg – object relations Mahler – object constancy Bowlby – insecure attachments Bipolar variant Recent review (Paris,Gunderson) did not support Complex PTSD Herman
“an unstable period” “a crucial stage or turning point” A sudden worsening
“frantic effort to avoid abandonment” manifests itself in an exaggerated, often maladaptive response Attempt to solicit caring response Present in crisis due to extreme response, instability, affect dysregulation, lack of social supports, trauma history Self harm, suicidality, aggression/anger, intoxication, risky impulsivity, psychosis/dissociation
Loss Abandonment Rejection Financial stress Impulsive behaviour Self-loathing Conflict in relationships Intoxication Being alone Trauma New Re-enactment Triggers
SPLITTING PROJECTIVE IDENTIFICATION Bad Object Good Object
IDEALIZED, GOOD OBJECT Rescuer Wants to help pt Takes over Over advocates Poor boundaries Reinforced by pt. statements such as: “you are the only one who has ever understood” DEVALUED, BAD OBJECT Dismisser Doesn’t listen or empathize Dismisses patient concerns Reacts angrily Challenging, confrontational Gives “cookbook”, unhelpful suggestions
RESCUER Feeds into splitting Divides team Decreased pt. Responsibility Boundary violations Isolated with pt. Burned out Abandon pt. DISMISSER Escalate pt. Anger Increased suicide risk Pt. Threats, complaints Reject pt.
Interactions can lead to re-enactments of negative, traumatic relationships Interactions can make pt. worse and increase suicide risk Important to be real, caring, set limits, enforce boundaries – therapeutic for the patient
8-10% of patients with BPD complete suicide Patients with BPD represent 9-33% of all suicides History of suicidal behaviour in 60-78% of patients with BPD Chronic suicidality with 4 or more visits to psych ED, most often diagnosed with BPD, 12% of all psych ED visits Common co-morbidities increase suicide risk BPD pts. have multiple suicide risk factors
McGirr et al., 2007 BPD suicide associated with higher levels Axis 1 co- morbidity, novelty seeking, hostility, co-morbid PD, lower levels harm avoidance Fewer psych hospitalizations and suicide attempts but increased SUD, cluster B co-morbidity Pompili et al., 2005 Higher rates of suicide in short term vs. Long term follow- up, suggests highest suicide risk in initial phases of illness Links suggests higher risk of suicide in young pts. (adolescence to 3 rd decade) Paris suggests higher risk of suicide in late 30s, no active treatment, failed treatment
Zaheer, Links, Liu Psychiatric clinics NA, 2008 ▪ RCT, 180 patients, BPD + recurrent suicidal behaviour ▪ Prospective trial to assess risk factors of high lethality vs. Low lethality attempters ▪ High lethality attempters: older, more children, PTSD, other PD esp. ASPD, specific phobia, anorexia, lower GAF, more childhood abuse, more exp to meds, more hospitalizations, more expectation of fatal outcome ▪ Independent variables: exp fatal outcome, schizotypal dim, PTSD, lower GAF, specific phobia, # psych admissions last 4 months ▪ “suffering chronic illness course with significant psychosocial impairment. These patients may be demonstrating an escalating series of suicide attempts with more and more suicide intention.”
Acute on chronic risk Acute stressors and acute risk factors increase acute risk Many BPD pts. meet criteria for Form 1/3 chronically Current Axis 1 co-morbidity, substance use, stressors, lack of protective factors and supports 3 signs that immediately precede pt. Suicide: a precipitating event, intense affective state, changes in behaviour patterns ▪ Hendin et al., 2001
Dawson – never admit a patient with BPD ▪ influential Paris, Linehan – recommend against admission ▪ Positively reinforcing socially ▪ Reinforces suicidal and self-destructive behaviours ▪ Regression Sometimes patients admitted due to lack of connection with resources APA Guidelines 2001 Indications for brief hospitalization: ▪ Imminent danger to others ▪ Serious suicide attempt, loss of control suicidal impulses ▪ Psychotic episodes with poor judgement/ poor impulse control ▪ Severe unresponsive symptoms interfering with functioning
Patient quote from Williams, 1998 ▪ “Do not hospitalize a person with BPD for more than 48 hours. My self-destructive episodes – one leading right into another – came out only after my first and subsequent hospital admissions, after I learned the system was usually obligated to respond....When you as a service provider do not give the expected response to these threats, you’ll be accused of not caring. What you are really doing is being cruel to be kind. When my doctor wouldn’t hospitalize me, I accused him of not caring if I lived or died. He replied, referring to my cycle of repeated hospitalizations, “That’s not life.” And he was 100% right.”
Pascual et al., 2007 ▪ 11,578 consecutive visits to psych ED ▪ BPD diagnosed for 9% (1032 visits), 540 individuals ▪ 11% hospitalized – suicide risk, danger to others, symptom severity, difficulty with self-care, non- compliance to treatment ▪ Pts. with BPD had greater clinical severity, percent hospitalized lower (11 vs 17%)
General Principles: ▪ Try to discharge ▪ Admit as briefly as possible ▪ Overnight in ER or holding beds ▪ Keep voluntary ▪ Carefully assessed diagnosis essential ▪ Care plans ▪ Good discharge planning
Triage BPD patients last as long as safely contained in ED Some pts leave before seen Some pts settle, use own resources to manage crisis + reinforcement of positive behaviour, - reinforcement extreme behaviours
Linehan, 1993 ▪ Listen to emotional content of sucidality/crisis and validate feelings ▪ Identify circumstances leading to feelings ▪ Dialogue with pt to develop alternative solutions Livesley, 2005 ▪ Safety and managing crises ▪ Containment ▪ Control and regulation ▪ Interventions to reduce self-harming behaviours ▪ Controlling and regulating dysphoria ▪ Reframing triggering situations
Listen and empathize ▪ Validate pt ▪ Help pt id emotions ▪ Develop rapport ▪ Rogers-empathy, non- judgemental, unconditional + regard Get at underlying trigger and emotion ▪ Often pt unaware ▪ Helps defuse ▪ Therapeutic ▪ Avoid, proactive Suicide assessment ▪ Expression of distress ▪ May shift ▪ Reassess regularly ▪ Acute vs. Chronic ▪ Don’t dwell on it ▪ May reflect escape, control
▪ Relief from emotional pain comes from connection to someone who understands ▪ Align with pt’s distress and offer support and understanding ▪ Weakened by failure to acknowledge distress, lengthy attempts to clarify feelings, interpretations ▪ Strategies ▪ Praised for seeking help ▪ Help pt id strengths Survival skills Put situation into perspective InterpretationConfrontationClarificationEncouragement to Elaborate Empathic Validation Advice and Praise Affirmation
▪ Mobilize supports-family, friends, professionals ▪ Stepwise way to approach crisis ▪ Follow-up arrangement ▪ Caring statements, photographs ▪ Can always come back to ED ▪ Joint Crisis Plans: pt and are team prepare ahead of time
▪ Reinforce successful adaptive strategies ▪ Distraction ▪ + self talk ▪ Thought stopping ▪ Substitution ▪ Grounding ▪ Journalling/artwork ▪ Emotion log/ emotion sheets
Benzodiazepines Antidepressants Mood stabilizers Antipsychotics ▪ AVOID except acutely ▪ Dependency ▪ SSRIs>MAOIs ▪ Low mood, anxiety, impulsivity, anger ▪ Anger management ▪ Safety risks – OD, preg ▪ Helps all symptoms ▪ Low dose, prn, ongoing ▪ Side effects ▪ Typical vs. atypical
Meds are tools to help with symptom control Meds symptom based vs. generally helpful First do no harm ▪ OD potential ▪ Pregnancy risk ▪ Med dependency/diversion ▪ withdrawal Prescriptions for small amounts
Pascual et al, 2008 ▪ 11,578 consecutive visits to psych ED over 4 years ▪ 1032 (9%) visits diagnosed BPD, 540 individuals ▪ Prescribe benzos Male sex, anxiety, good self care, few med or drug problems, housing instability ▪ Prescribe antipsychotics Male sex, danger to others, psychosis ▪ Prescribe antidepressants Depression, little premorbid dysfunction
Damsa et al, 2007 ▪ 25 pts, severe agitation + BPD ▪ Received 10mg im olanzapine ▪ Reduced agitation, good tolerance within 2hrs ▪ 16% required second dose Pascual et al, 2004 ▪ 12 BPD pts ▪ Received ziprasidone 20mg im then oral ziprasidone mg/day, monitored up to 2 weeks ▪ Overall significant improvement, well tolerated
Helpful to give the patient something ▪ Follow-up appointment ▪ Crisis line number ▪ Prescription/meds ▪ Voice mail ▪ Treatment plan ▪ Written note
Beware No medico-legal value Does not replace assessment, treatment plan, documentation Helpful when ongoing therapeutic relationship Sometimes helpful as part of suicide assessment Do not base clinical decisions on contract