Blood and Hematopoiesis Quiz

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1. Reticulocytes may be identified by light microscopy due to their containing basophilic remnants of Amino acids DNA Lipids RNA Sugars :00

2. As the last step in neutrophilic granulocytopoiesis, Antigen-stimulated monocytes differentiate into plasma cells Band cell nuclei will begin to become segmented Orthochromatophylic eryhtroblasts divide to form reticulocytes Monoblasts divide to form lymphocytes Eosinophilic granules are produced :00

Albumin Band 3 protein Hemoglobin Spectrin P-selectin 3. Hereditary spherocytosis is a condition which involves a defect in a cytoskeletal protein of the erythrocyte, causing an abnormal spherical cell shape. This protein is Albumin Band 3 protein Hemoglobin Spectrin P-selectin :00

4. One function of the helper T lymphocytes is to stimulate B lymphocytes to undergo mitosis and subsequent differentiation into Antibodies Antigens Cytotoxic cells Natural killer cells Plasma cells :00

5. The predominant component(s) of blood plasma, making up roughly 90% of its weight is/are Albumin Neutrophils Protein Solutes Water :00

6. The predominant protein(s) in blood plasma is/are Albumins Fibrinogens Globulins Hemoglobin Red blood cells :00

7. The predominant cell type(s) in blood is/are Leukocytes Lymphocytes Neutrophils Platelets Red blood cells :00

8. The predominant leukocytic cell type in blood is/are Basophils Lymphocytes Monocytes Neutrophils T cells :00

9. The agranulocyte lineage of leukocytes contains the lymphocytes and what other cell type? Erythrocytes Macrophages Megakaryocytes Monocytes Neutrophils :00

Cytoskeletal filament Platelet Stereocilia Tight junction 10. Senescence of red blood cells is a process in which aged cells are destroyed by macrophages. The Band 3 protein involved in this process is actually a type of Chloride channel Cytoskeletal filament Platelet Stereocilia Tight junction :00

11. What is the most common human hemoglobin type? HbA HbA2 HbF HbH HbS :00

Liver Lymph nodes Spleen Thymus Yellow bone marrow 12. Erythrocyte senesence ultimately leads to destruction by macrophages predominantly in which organ ? Liver Lymph nodes Spleen Thymus Yellow bone marrow :00

13. The typical lifespan of a circulating erythrocyte is 1-2 hours 2 days 120 days 2 weeks 2 years :00

13. Of the 4 common, human blood types, Type O is unique in that an individual possesses red blood cells with no A or B antigens and Both A and B antibodies No A or B antibodies Only A antibodies Only B antibodies Only C antibodies :00

Non-staining granules Prolonged lifespan Segmentation of their nuclei 15. Neutrophils are motile cells. Microtubules play an important role in this locomotion ability along with Actin and myosin Large cell size Non-staining granules Prolonged lifespan Segmentation of their nuclei :00

Collagen Collagenase Hemoglobin Keratin Major basic protein 16. Eosinophil specific granules stain eosinophilic giving the cell its characteristic red color. The predominant protein in the eosinophil specific granule is Collagen Collagenase Hemoglobin Keratin Major basic protein :00

Antibodies Collagenase Heparin and Histamine Major basic protein 17. Basophils are functionally similar to mast cells in that they secrete granules containing similar protein content, notably Antibodies Collagenase Heparin and Histamine Major basic protein P-selectin :00

B cell Macrophage Natural Killer cell Plasma cell T cell 18. Humoral immunity is mediated by B cells which upon activation by antigen recognition differentiate into a cell capable of producing antibodies, the B cell Macrophage Natural Killer cell Plasma cell T cell :00

Cytotoxic Helper Memory Natural Suppressor 19. Cell-mediated immunity is a function of many cells including T cells. A T cell which directly acts to kill cells expressing foreign antigens on their surface is termed Cytotoxic Helper Memory Natural Suppressor :00

It doesn’t occur It involves the CNS It is larger in scope 20. Memory B cells derive from a naïve B cells initial exposure to a foreign antigen. What is true of the immune response of a memory B cell after a second exposure to that antigen? It doesn’t occur It involves the CNS It is larger in scope It is slower It is smaller :00

21. Platelets are cell fragments that derive from which cell type? Megakaryocytes Monocytes Osteocytes Plasma cells T lymphocytes :00

Major histocompatibility complex 22. Platelets contain structures called granulomeres that contain numerous proteins. A key protein in the granulomere is a growth factor important in blood vessel growth and regeneration, and is named Leptin Major histocompatibility complex Platelet-derived growth factor P-selectin Perforin :00

Demarcation membranes Granulomeres Megakaryocytopoiesis Smooth muscle 23. Platelets possess contractile activity, and play an important role in repairs to blood vessels. This contractile activity in platelets is mediated in part by Actin and myosin Demarcation membranes Granulomeres Megakaryocytopoiesis Smooth muscle :00

24. Inactive marrow that functions primarily to store fat is termed Multilocular Red Unilocular White Yellow :00

Basophils, eosinophils, neutrophils, monocytes Erythrocytes 25. Colony stimulating factors (CSFs) are compounds which influence hematopoiesis and promote the production of specific cell types. One key example, GM-CSF, when released, could lead to the increased production of which of the following cell types? B lymphocytes Basophils, eosinophils, neutrophils, monocytes Erythrocytes Megakaryocytes T lymphocytes :00

B lymphocytes Basophils Erythrocytes Megakaryocytes T lymphocytes :00 26. Hematopoietic growth factors direct the production of cell types in the bone marrow. Erythropoietin, a factor produced by the kidney increases the production of which cell type? B lymphocytes Basophils Erythrocytes Megakaryocytes T lymphocytes :00

CFU-E CFU-GEMM CFU-GM CFU-Ly CFU-Meg :00 27. Colony forming units (CFUs) are groups of cells which have committed to a common lineage in hematopoiesis. CFU-Ly defines cells which have committed to the lymphocyte lineage. Which common colony forming unit is responsible for the formation of granulocytes, monocytes, erythrocytes, and megakaryocytes? CFU-E CFU-GEMM CFU-GM CFU-Ly CFU-Meg :00

Colony stimulating factor Hemonectin Heparin Lymphokine P-selectin 28. The bone marrow stroma is composed of adventitial cells which form a reticular network to support the marrow tissue and hematopoietic cell network. Hematopoietic cells bind to this network through a marrow-specific adhesion protein called Colony stimulating factor Hemonectin Heparin Lymphokine P-selectin :00

Basophil Eosinophil Lymphocyte Monocyte Neutrophil :00 29. Examination of a normal peripheral blood smear reveals a cell more than twice the diameter of an erythrocyte with a kidney-shaped nucleus. These cells were <10% of total leukocytes. Which of the following cell types is being described? Basophil Eosinophil Lymphocyte Monocyte Neutrophil :00

Erythroblast Lymphoblast Platelet Promyelocyte Unilocular adipocyte 30. Basophils, neutrophils, and eosinophils differentiate through a final common granulocytic precursor cell termed the Erythroblast Lymphoblast Platelet Promyelocyte Unilocular adipocyte :00

Erythroblast Myeloblast Platelet Reticulocyte T cell 31. In the pathway of erythrocytopoiesis, the final defined precursor cell before the formation of a mature erythrocyte is called a Erythroblast Myeloblast Platelet Reticulocyte T cell :30

IgE antibody Collagenase Hemonectin Major binding protein P-selectin 32. The neutrophil is considered to ‘reside’ in several theoretical compartments during its development and lifespan. From its circulation in the bloodstream the neutrophil is able to migrate into connective tissue spaces upon binding a key endothelial cell adhesion molecule called IgE antibody Collagenase Hemonectin Major binding protein P-selectin :30

Sticky glycoprotein coat 33. When a blood vessel is damaged a coordinated sequence of events involving many cell types and proteins takes place. One of the initial steps is the aggregation of platelets to form a platelet plug at the site of the damage where collagen from connective tissue is exposed to the blood. The aggregation at this site is possible due to the platelets having IgE antibody Collagenase Hemonectin Major binding protein Sticky glycoprotein coat :30

34. Identify this cell (arrow, black). Basophil Eosinophil Lymphocyte Monocyte Neutrophil :30

35. Identify this cell (arrow, black). Basophil Eosinophil Lymphocyte Monocyte Neutrophil :30

36. Identify this cell (arrow, black). Basophil Eosinophil Lymphocyte Monocyte Neutrophil :30

37. Identify these structures (arrows, black). Cellular debris Erythrocytes Platelets Processing artifact Reticulocytes :30

38. Identify this cell (arrow, black). Basophil Eosinophil Lymphocyte Monocyte Neutrophil :30

39. Identify this cell (arrow, black). Basophil Eosinophil Lymphocyte Monocyte Neutrophil :30

40. Identify this cell (arrow, black). Basophil Eosinophil Lymphocyte Monocyte Neutrophil :30

41. Identify this cell (arrow, black). Basophil Eosinophil Lymphocyte Monocyte Neutrophil :30

42. Identify this cell (arrow, black). Basophil Eosinophil Lymphocyte Monocyte Neutrophil :30

43. Identify this cell (arrow, black). Basophil Eosinophil Lymphocyte Monocyte Neutrophil :30

44. Identify this cell (arrow, black). Basophil Eosinophil Lymphocyte Monocyte Neutrophil :30

45. Identify this cell (arrow, black). B lymphocyte Eosinophil Megakaryocyte Monocyte Neutrophil :30

46. Identify this structure (arrow, black). Eosinophil Lymphatic vessel Megakaryocyte Sinusoid T lymphocyte :30

47. Identify these cells (arrows, black). Adipocytes Erythrocytes Lymphocytes Megakaryocytes Monocytes :30

48. Identify these cells (arrows, black). B lymphocytes Eosinophils Megakaryocytes Monocytes Neutrophils :30

49. Identify these structures (arrows, black). Eosinophils Lymphatic vessels Megakaryocytes Sinusoids Woven bone :30

50. In this image of a bone marrow smear, the indicated cells belong to which hematopoietic lineage (arrows, black)? B lymphocyte Erythroid Lymphoid Monocytic Myeloid :30

Basophils Eosinophils Lymphocytes Monocytes Neutrophils :30 51. Your patient is suffering from an infestation of parasites. To determine the proper therapy, you perform an analysis of a peripheral blood sample. Which of the following cells would you expect to be increased in a peripheral blood smear? Basophils Eosinophils Lymphocytes Monocytes Neutrophils :30

52. A decrease in the number of tissue macrophages would result from reduced activity of precursor cells to which of the following cell types? Basophils Erythrocytes Monocytes Neutrophils Megakaryocytes :30

53. Which of the following cells is the primary phagocytic cell within peripheral blood? Basophil Eosinophil Lymphocyte Monocyte Neutrophil :30

Amino acid change of the globin moecule 54. Pernicious anemia develops as a consequence of which of the following? Amino acid change of the globin moecule Decreased levels of intrinsic factor Decreased iron Decreased platelets Decreased synthesis of hemoglobins :30

Organ transplant rejection Parasitic infection Pollen infestation 55. While examining a peripheral blood smear, you notice an increased number of cells slightly larger than an erythrocyte. These cells have a large, round nucleus and scant cytoplasm. Which of the following would cause this condition? Bacterial infection Hemorrhage Organ transplant rejection Parasitic infection Pollen infestation :30

Hemophilia Pernicious anemia Polycytothemia Thalassemia 56. A young man complains that he bruises easily. A laboratory report showed a normal white cell count. Erythrocytes were 5 million/mm3, whereas platelets were 50,000/mm3. Which of the following was the diagnosis? Hemophilia Pernicious anemia Polycytothemia Thalassemia Thrombocytopenia :30

57. Which of the following blood cells differentiate outside of the bone marrow? Basophils Eosinophils Megakaryocytes Neutrophils T lymphocytes :30

Cell-mediated immune response Hemorrhage 58. An analysis of a peripheral blood smear showed that reticulocytes were 10% of total cells. Which of the following represents the proper diagnosis? Cell-mediated immune response Hemorrhage Humoral-mediated immune response Infection Myelocytic leukemia :30

Polychromatophilic erythroblast Platelet Proerythroblast 59. Which of the following is not derived by a mitotic division of a precursor cell? Monocyte Osteoblast Polychromatophilic erythroblast Platelet Proerythroblast :30

Basophils Erythrocytes Lymphocytes Monocytes Platelets :30 60. Examining a peripheral blood smear, you note a cell type that consists of both large and small cells intermixed with normal size cells, a condition described as anisocytosis. This abnormal condition refers to which of the following? Basophils Erythrocytes Lymphocytes Monocytes Platelets :30

Basophilic erythroblast Hematopoietic stem cell 61. Your patient suffers from a blood disorder that requires chemotherapy. A bone marrow transplant is subsequently performed. Transplants containing which of the following cells in the erythrocytic series would not provide proliferative cells? Basophilic erythroblast Hematopoietic stem cell Orthochromatophilic erythroblast Polychromatophilic erythroblast Proerythroblast :30

Hematopoietic stem cell Metamyelocyte Myeloblast Myelocyte 62. At which of the following stages are specific cells of the granulocytic series first recognizable? Hematopoietic stem cell Metamyelocyte Myeloblast Myelocyte Promyelocyte :30

Basophilic erythroblast Orthochromatophilic erythroblast 63. Hemoglobin is first seen in which of the following cells of the erythrocytic series? Basophilic erythroblast Orthochromatophilic erythroblast Polychromatophilic erythroblast Proerythroblast Reticulocyte :30

Basophilic erythroblast Orthochromatophilic erythroblast 64. In which of the following cells of the erythrocytic series is the nucleus extruded? Basophilic erythroblast Orthochromatophilic erythroblast Polychromatophilic erythroblast Proerythroblast Reticulocyte :30

Basophilic erythroblast Myelocyte Neutrophilic metamyelocyte 65. While examining cells of a bone marrow smear with the light microscope, you notice a cell whose cytoplasm has no noticeable granules. The nucleus of this cell in indented and contains no nucleoli. Which of the following cells are you examining? Basophilic erythroblast Myelocyte Neutrophilic metamyelocyte Polychromatophilic erythroblast Promyelocyte :30

66. Which of the following best characterizes bone marrow? All blood cells undergo maturation within the bone marrow Destruction of erythrocytes is carried out in red bone marrow Lymphocytes mature in bone marrow Monocytes mature in bone marrow Yellow bone marrow does not function to produce blood cells :30

Eosinophilic leukemia Lymphoblastic leukemia Promyelocytic leukemia 67. A sample of peripheral blood from a patient reveals a larger than normal population of cells that have large, round nuclei with 1 or 2 nucleoli. The cytoplasm of these cells shows azurophilic granules. Which of the following forms of leukemia would you suspect? Basophilic leukemia Eosinophilic leukemia Lymphoblastic leukemia Promyelocytic leukemia Stem cell leukemia :30

Neutrophilic metamyelocyte Neutrophilic myelocyte 68. A peripheral blood smear of a person suffering from a mild form of leukemia showed a large number of cells with more than 1 nucleolus. Which of the following cells is being described? Myeloblast Neutrophilic metamyelocyte Neutrophilic myelocyte Orthochromatophilic erythroblast Polychromatophilic erythroblast :30

Basophilic erythroblasts Megakaryoblasts Metamyelocytes 69. Your patient suffers from lymphocytic leukemia. Chemotherapy is administered to destroy cancerous cells of the bone marrow. Precursor cells to erythrocytes are destroyed. To specifically re-establish the erythrocytic cell line, which of the following cells should be transplanted? Basophilic erythroblasts Megakaryoblasts Metamyelocytes Orthochromatophilic erythroblasts Reticulocytes :30

70. As cells undergo the process of erythropoiesis, which of the following occurs? Chromatin becomes more diffuse Nuclei become lobulated Nuclei decrease in size Nucleoli increase in number Rough endoplasmic reticulum increases within the cytoplasm :30