Pre Test !!!!!!. How many classes of HIV meds are currently available? 1. 1 2. 2 3. 3 4. 4 5. 5.

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Presentation transcript:

Pre Test !!!!!!

How many classes of HIV meds are currently available?

A side effect with Reyataz (atazanavir) which is reversible when discontinued is? 1. Discoloration of the fingernail and toe nails 2. Hyperbilirubinemia 3. Kidney Failure 4. Liver Failure

HIV stands for: 1. Hawaiian Island Visitors 2. Human Immunodeficiency Virus 3. Hepatitis Injection Vaccine 4. None of the above

The first three steps involved in HIV cell entry include all of the following except: 1. Fusion 2. Integration 3. Attachment 4. Co-receptor binding

All the following are combination formulations except for? 1. Epivir 2. Combivir 3. Epzicom 4. Trizivir

Like Hepatitis C, HIV is… 1. A harmless virus 2. A bloodborne virus 3. A curable virus 4. None of the above

What HIV med causes Vivid Dreams? 1. Selzentry (Maraviroc) 2. Sustiva (Efavirenz) 3. Lexiva (Fosamprenavir) 4. None of the above

Living or working with a person who is infected with HIV can cause someone to get HIV 1. False 2. True

What must one be careful of when taking Ziagen (abacavir)? 1. Acne 2. Cough 3. Runny nose 4. Hypersensitivity reaction

The most common side effect found with the “D” drugs is? 1. Diarrhea 2. Nausea 3. Headaches 4. Peripheral Neuropathy

Consistent and correct condom use can prevent HIV 1. True 2. False

HIV can be transmitted by: 1. Sharing dirty needles 2. Blood 3. Semen 4. Vaginal Fluids 5. All of the above 6. None of the above

Before beginning Selzentry (maraviroc) what type of lab test must be performed? 1. CBC w/ Diff 2. Hct & Hgb 3. Trophile 4. LFT

The only HIV medication currently on the market which is injected is? 1. Retrovir 2. Fuzeon 3. Crixivan 4. Combivir

One of the body fluids that can transmit HIV is: 1. Tears 2. Saliva 3. Urine 4. Breast milk

All of the following agents are Protease Inhibitors except? 1. Prezista (darunavir) 2. Lexiva (fosamprenavir) 3. Viracept (nelfinavir) 4. Ziagen (abacavir)

Trizivir, although is a 3 med combo it should not be used alone because…. 1. It is too expensive 2. There are too many side effects 3. It does not sustain good results as triple nuc therapy 4. None of the above

The first medication used in HIV was? 1. Crixivan (Indinavir) 2. Invirase (Saquinavir) 3. Sustiva (Efavirenz) 4. Retrovir (Zidovudine)

What is the least number of HIV meds that can be used to treat HIV?

What HIV med is used as a booster? 1. Viracept (Nelfinavir) 2. Reyataz (Atazanavir) 3. Norvir (Ritonavir) 4. Viramune (Nevirapine)

The newest HIV medication combined into one pill and taken once a day by two different manufacturers is? 1. Trizivir 2. Combivir 3. Atripla 4. Epzicom

HIV Medications 101 Fred Cruz, R.Ph. Pharmacist-In-Charge CarePlus CVS/pharmacy

My Personal Story

TEST !!!!!

What is Fred’s male dog’s name? 1. Thor 2. Zeuz 3. Hercules 4. Rudy

What is Fred’s female dogs name? 1. Xena 2. Aphrodite 3. Athena 4. None of the above

What is Fred’s partners occupation? 1. Pharmacist 2. Architect 3. Police officer 4. Doctor

How many pictures did it take to get the family picture of the dogs?

What made Fred interested in working with HIV? 1. HIV medications are always changing 2. His friend a pharmacist had a brother who died of HIV 3. Fred has had many friends die of HIV 4. All of the above

CarePlus Pharmacy Team

HIV Myths

HIV stands for: 1. Hawaiian Island Visitors 2. Human Immunodeficiency Virus 3. Hepatitis Injection Vaccine 4. None of the above

Living or working with a person who is infected with HIV can cause someone to get HIV 1. False 2. True

Like Hepatitis C, HIV is… 1. A harmless virus 2. A bloodborne virus 3. A curable virus 4. None of the above

Consistent and correct condom use can prevent HIV 1. True 2. False

HIV can be transmitted by: 1. Sharing dirty needles 2. Blood 3. Semen 4. Vaginal Fluids 5. All of the above 6. None of the above

One of the body fluids that can transmit HIV is: 1. Tears 2. Saliva 3. Urine 4. Breast milk

HIV Life Cycle

Videos

HIV: Antiretroviral Therapy HIV RNA HIV DNA HIV Nucleus Host Cell Non-Nucleoside RTI Nucleoside RTI Integrase Inhibitors Protease Inhibitors Entry Inhibitors

Classes of HIV Meds Protease Inhibitors (PI’s) Protease Inhibitors (PI’s) Nucleoside Reverse Transciptase Inhibitors (NRTI’s) Nucleoside Reverse Transciptase Inhibitors (NRTI’s) Non-Nucleoside Reverse Transciptase Inhibitors (NNRTI’s) Non-Nucleoside Reverse Transciptase Inhibitors (NNRTI’s) Entry Inhibitors Entry Inhibitors Integrase Inhibitors Integrase Inhibitors

Classes of HIV meds in the pipeline Maturation Inhibitors Maturation Inhibitors Cellular Inhibitors Cellular Inhibitors Immune Based Therapies Immune Based Therapies

NNRTI ’87 ’91 ’92 ’94 ’95’96 ’97 ’98 ’99 ’00 ’88 ’89’90 NRTI PI Approved Antiretrovirals Retrovir Norvir Invirase Crixivan Fortovase Kaletra Viracept Ziagen Combivir Videx Hivid Zerit Epivir Trizivir Rescriptor Sustiva Viramune ’01 Viread Emtriva Reyataz ’02’03 ’93 Agenerase FI FUZEON Retrovir, Epivir, Combivir, Ziagen, Agenerase, Lexiva and Trizivir are trademarks of GlaxoSmithKline. Videx, Zerit, Sustiva and Reyataz are trademarks of Bristol-Myers Squibb. Norvir and Kaletra are registered trademarks of Abbott. Crixivan is registered trademark of Merck. Viramune is registered trademark of Boehringer Ingelheim. Viracept and Rescriptor are registered trademarks of Agouron. Viread and Emtriva are trademarks of Gilead. Hivid, Invirase, Fortovase and FUZEON are registered trademarks of Roche Laboratories. Lexiva

HAART = High Active Anti-Retroviral Therapy

NRTI’s (Nucleoside Reverse Transciptase Inhibitors) Combivir (zidovudine + lamivudine, AZT + 3TC) Combivir (zidovudine + lamivudine, AZT + 3TC) Combivir Emtriva (emtricitabine, FTC) Emtriva (emtricitabine, FTC) Emtriva Epivir (lamivudine, 3TC) Epivir (lamivudine, 3TC) Epivir Epzicom (abacavir + lamivudine, ABC + 3TC) Epzicom (abacavir + lamivudine, ABC + 3TC) Epzicom Retrovir (zidovudine, AZT, ZDV) Retrovir (zidovudine, AZT, ZDV) Retrovir Trizivir (abacavir + zidovudine + lamivudine, ABC + AZT + 3TC) Trizivir (abacavir + zidovudine + lamivudine, ABC + AZT + 3TC) Trizivir Truvada (tenofovir DF + emtricitabine, TDF + FTC) Truvada (tenofovir DF + emtricitabine, TDF + FTC) Truvada Videx & Videx EC (didanosine, ddI) Videx & Videx EC (didanosine, ddI) Videx Viread (tenofovir disoproxil fumarate, TDF) Viread (tenofovir disoproxil fumarate, TDF) Viread Zerit (stavudine, d4T) Zerit (stavudine, d4T) Zerit Ziagen (abacavir, ABC) Ziagen (abacavir, ABC) Ziagen

NRTI’s in the Pipeline Racivir (RCV) Racivir (RCV) Racivir Amdoxovir (AMDX, DAPD) Amdoxovir (AMDX, DAPD) Amdoxovir Apricitabine (SPD754, AVX754) Apricitabine (SPD754, AVX754) Apricitabine Elvucitabine (ACH-126,443, Beta-L-Fd4C) Elvucitabine (ACH-126,443, Beta-L-Fd4C) Elvucitabine

NNRTI’s (Non-Nucleoside Reverse Transciptase Inhibitors) Intelence (etravirine, TMC-125) Intelence (etravirine, TMC-125) Intelence Rescriptor (delavirdine, DLV) Rescriptor (delavirdine, DLV) Rescriptor Sustiva (efavirenz, EFV) Sustiva (efavirenz, EFV) Sustiva Viramune (nevirapine, NVP) Viramune (nevirapine, NVP) Viramune

NNRTI’s in the Pipeline Rilpivirine (TMC- Rilpivirine (TMC- Rilpivirine

PI’s (Protease Inhibitors) Agenerase (amprenavir, APV) Agenerase (amprenavir, APV) Agenerase Agenerase Aptivus (tipranavir, TPV) Aptivus (tipranavir, TPV) Aptivus Crixivan (indinavir, IDV) Crixivan (indinavir, IDV) Crixivan Invirase (saquinavir, SQV) Invirase (saquinavir, SQV) Invirase Kaletra (lopinavir/ritonavir, LPV/r) Kaletra (lopinavir/ritonavir, LPV/r) Kaletra Lexiva (fosamprenavir, FPV) Lexiva (fosamprenavir, FPV) Lexiva Norvir (ritonavir, RTV) Norvir (ritonavir, RTV) Norvir Prezista (darunavir, DRV) Prezista (darunavir, DRV) Prezista Reyataz (atazanavir, ATV) Reyataz (atazanavir, ATV) Reyataz Viracept (nelfinavir) Viracept (nelfinavir) Viracept

Entry Inhibitors Fuzeon (enfuvirtide, ENF, T-20) Fuzeon (enfuvirtide, ENF, T-20) Fuzeon Fuzeon Selzentry (maraviroc, UK-427,857) Selzentry (maraviroc, UK-427,857) Selzentry Selzentry

Entry Inhibitors in the Pipeline Vicriviroc (SCH , SCH-D) Vicriviroc (SCH , SCH-D) Vicriviroc PRO 140 PRO 140 PRO 140 PRO 140 TNX-355 TNX-355 TNX-355

Integrase Inhibitors Isentress (raltegravir, MK-0518) Isentress (raltegravir, MK-0518) Isentress

Integrase Inhibitors in the Pipeline Elvitegravir (GS-9137) Elvitegravir (GS-9137) Elvitegravir

HIV Treatment: Then and Now ‡

DHS/HIV/PP ????????’s

Post Test HIV Meds 101

The first three steps involved in HIV cell entry include all of the following except: 1. Fusion 2. Integration 3. Attachment 4. Co-receptor binding

The first medication used in HIV was? 1. Crixivan (Indinavir) 2. Invirase (Saquinavir) 3. Sustiva (Efavirenz) 4. Retrovir (Zidovudine)

How many classes of HIV meds are currently available?

What is the least number of HIV meds that can be used to treat HIV?

What HIV med causes Vivid Dreams? 1. Selzentry (Maraviroc) 2. Sustiva (Efavirenz) 3. Lexiva (Fosamprenavir) 4. None of the above

What HIV med is used as a booster? 1. Viracept (Nelfinavir) 2. Reyataz (Atazanavir) 3. Norvir (Ritonavir) 4. Viramune (Nevirapine)

All of the following agents are Protease Inhibitors except? 1. Prezista (darunavir) 2. Lexiva (fosamprenavir) 3. Viracept (nelfinavir) 4. Ziagen (abacavir)

What must one be careful of when taking Ziagen (abacavir)? 1. Acne 2. Cough 3. Runny nose 4. Hypersensitivity reaction

The newest HIV medication combined into one pill and taken once a day by two different manufacturers is? 1. Trizivir 2. Combivir 3. Atripla 4. Epzicom

Trizivir, although is a 3 med combo it should not be used alone because…. 1. It is too expensive 2. There are too many side effects 3. It does not sustain good results as triple nuc therapy 4. None of the above

The most common side effect found with the “D” drugs is? 1. Diarrhea 2. Nausea 3. Headaches 4. Peripheral Neuropathy

Before beginning Selzentry (maraviroc) what type of lab test must be performed? 1. CBC w/ Diff 2. Hct & Hgb 3. Trophile 4. LFT

A side effect with Reyataz (atazanavir) which is reversible when discontinued is? 1. Discoloration of the fingernail and toe nails 2. Hyperbilirubinemia 3. Kidney Failure 4. Liver Failure

The only HIV medication currently on the market which is injected is? 1. Retrovir 2. Fuzeon 3. Crixivan 4. Combivir

All the following are combination formulations except for? 1. Epivir 2. Combivir 3. Epzicom 4. Trizivir

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