View drawing guides 1.Right-click on slide and select ’Grid and Guides...’ 2.Check ’Display drawing guides on screen’ 3.Select ’OK’ September 27 th, 2012 Stan Mainzer DuPont Industrial Biosciences “Current and Future Trends in Industry” “WHITE BIOTECHNOLOGY”

Text starts with no bullet Click once on ’Increase Indent’ for bullet and click max. three times for more bulletdesign To get previous design back, click on ’Decrease Indent’ Change Date and insert Presentation Title under >Insert >Header and Footer and write in Fixed Date field and field ‘Footer’ >Apply to All Deactivate by clicking off the checkboxes Who is DuPont Industrial Biosciences? Genentech & & DuPont Industrial Biosciences & 1982 to 2012: 30 years of industrial biotechnology = 2

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Key Market Segments in Our Business 4 Bioactives Biomaterials Biorefineries ProductsEnd use markets Enzymes, proteins, peptides Food and beverages, feed, cleaning, paper, personal care Biochemicals Biomaterials Carpet, textiles, automotive Ethanol Biobutanol Bioprocessing aids Fuels, carbohydrates Agriculture and Nutrition Industrial Biosciences Advanced Materials Bioactives Biorefineries Biomaterials Core Core Elements Renewable, biobased inputs Design and operation of cell factories Deliver enhanced process and product sustainability

Processing Extraction Conversion Separation Biotechnology Genomics Molecular biology Fermentation Health Nutrition science Immunology Microbiology Application Food science Formulation knowledge Sensory science 5 DuPont Nutrition & Health Industry Leading Science Digestive Immune Weight Bone Heart Oral Sports

Focused on Three Biobased Segments Serving a diverse set of customers 6 Biobased ProductsEnd use markets Bioactives Biomaterials Biorefineries: Biofuels Enzymes, proteins, peptides Food and beverages, feed, cleaning, paper, personal care Biochemicals Biomaterials Carpet, textiles, automotive Ethanol Biobutanol Bioprocessing aids Fuels, carbohydrates Bio/chemical transformation Biomass Sugars Bio/chemical transformation Our Competitive Advantage Carbon SourcesConversion Starch

Bakery Enzymes

8 Amylases / Starch Acting Enzymes Pullulanase  -amylase  -amylase Amyloglucosidase Pullulanase Amyloglucosidase

9 Amylases as Anti-staling Agent

Text starts with no bullet Click once on ’Increase Indent’ for bullet and click max. three times for more bulletdesign To get previous design back, click on ’Decrease Indent’ Change Date and insert Presentation Title under >Insert >Header and Footer and write in Fixed Date field and field ‘Footer’ >Apply to All Deactivate by clicking off the checkboxes C-OCH 2 CH 2 CH 2 O)- O -(-C O n + DMT / TPA Unique polymer with versatile properties 37wt% renewable content Catalyst 1,3-propanediol Sorona® polymer DuPont™ Sorona® Bio-Based PTT Polymer Bio-PDO™ PTT = Polytrimethylene Terephthalate 10

DuPont™ Sorona® - Carpet & Apparel Applications Stain Resistance “Engineered Into” the fibers Resiliency Bright color & Infinite Color Choices Superior Soft Touch Bio-PDO™Strong Environmental Benefits Residential Carpet Commercial Carpet Aotomotive Carpet Apparel 11

DuPont and Goodyear jointly develop BioIsoprene™ Process DuPont and The Goodyear Tire & Rubber Company: an integrated process to, manufacture BioIsoprene™ product at industrial scale A collaborative research initiative Joint multimillion-dollar investment BioIsoprene™ product is a bio-based, renewable alternative to the petroleum-based isoprene BioIsoprene™ is a “business platform chemical” DuPont will lead commercial development Concept tire – not available to consumers 17 Biomaterials 12 DuPont Confidential

Text starts with no bullet Click once on ’Increase Indent’ for bullet and click max. three times for more bulletdesign To get previous design back, click on ’Decrease Indent’ Change Date and insert Presentation Title under >Insert >Header and Footer and write in Fixed Date field and field ‘Footer’ >Apply to All Deactivate by clicking off the checkboxes A BioIsoprene™ Cell Factory Multiple feedstocks possible Two feeder pathways to isoprene precursor Isoprene synthase C6 ► 3C (C5) 3C ► 2C 16C ► 2C Isoprene Synthase Isoprene Recovery Glucose Sucrose / Biomass Glycerol Plant Oils MEP Pathway MVA Pathway Cells Conceptual View of the Isoprene Cell Factory 13

Text starts with no bullet Click once on ’Increase Indent’ for bullet and click max. three times for more bulletdesign To get previous design back, click on ’Decrease Indent’ Change Date and insert Presentation Title under >Insert >Header and Footer and write in Fixed Date field and field ‘Footer’ >Apply to All Deactivate by clicking off the checkboxes Enabling the Biochemicals & biofuels industries through our unique expertise 14

The Overall Design of the CE Biorefinery 15

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Together we can accomplish what can’t be done alone. Thank you. gnext.genencor.com |

Copyright © 2012 DuPont or its affiliates. All rights reserved. The DuPont Oval Logo, DuPont™ Danisco ® and all products denoted with ™ or ® are registered trademarks or trademarks of E. I. du Pont de Nemours and Company or its affiliates. 21

Text starts with no bullet Click once on ’Increase Indent’ for bullet and click max. three times for more bulletdesign To get previous design back, click on ’Decrease Indent’ Change Date and insert Presentation Title under >Insert >Header and Footer and write in Fixed Date field and field ‘Footer’ >Apply to All Deactivate by clicking off the checkboxes Food Health Need to increase food supply significantly Rising raw material prices Need for affordable and sustainable food Trend for natural, clean label product Twin challenges of obesity and aging Chronic disease Food safety and pandemics Demand for healthy foods We will be the premier specialty food ingredient and food safety leader Nutrition Safety Sustainability Nutrition & Health: Business Opportunity 22