VII edizione Capri Pediatria Capri, 28 – 30 Aprile 2014 Biomarkers nell’asma bronchiale Guglielmo Scala Napoli.

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Presentation transcript:

VII edizione Capri Pediatria Capri, 28 – 30 Aprile 2014 Biomarkers nell’asma bronchiale Guglielmo Scala Napoli

Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008

Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008 La cellula Th2 è fondamentale per la maturazione dell’eosinofilo

Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008

A new look at the pathogenesis of asthma Holgate ST, 2010, Clinical Science

A new look at the pathogenesis of asthma Holgate ST, 2010, Clinical Science

Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008

Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008 Nasce il concetto di EMTU

Lamina basale è prodotta dalle cell epiteliali Lamina reticolare (MBR) è prodotta dai fibroblasti

A new look at the pathogenesis of asthma Holgate ST, 2010, Clinical Science

Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008

Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment P. Holt & P. Sly, Nature Medicine, 2012

Holt & Sly, Nat Med 2012

Holt P, Curr Op Allergy Clin Immunol, 2007 ITS

Holt & Sly, Nat Med 2012

Smascherata la marcia atopica??

The basics of epithelial-mesenchymal transition Kalluri R, Weinbergjj R, J Clin Invest

The basics of epithelial-mesenchymal transition Kalluri R, Weinbergjj R, J Clin Invest

A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients. Khayyal MT 2003, Fundam Clin Pharmacol FVC+ 19% FEV1+30% PEFR+30% FEF % TNF-52% ICAM-1-65% IL-6-44% IL-8-30% IL % Asma notturno/settimana- 60 % 22 pazienti : placebo 24 pazienti : propoli

Brazilian Green Propolis: Anti-Inflammatory Property by an Immunomodulatory Activity Machado JL et al, 2012, Evidence-Based Compl Altern Med

Caffeic acid phenethyl ester inhibits nuclear factor-kB and protein kinase B signalling pathways and induces caspase- 3 expression in primary human CD4+ T cells Wang et al, 2009, Clin Exp Immunol The inhibitory effect of CAPE results in the inhibition of cytokine production and proliferation in primary human CD4+ T cells

Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human Polymorphonuclear Leukocytes. Boudreau L, 2012, PlosOne

Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol TGF - 

Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol TGF -  Alterazioni morfologiche ↓ E - cadherin ↑ N - cadherin ↑ ROS ↑ motilità cellulare

Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol TGF -  Alterazioni morfologiche ↓ E - cadherin ↑ N - cadherin ↑ ROS ↑ motilità cellulare PROPOLI

Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol TGF -  Alterazioni morfologiche ↓ E - cadherin ↑ N - cadherin ↑ ROS ↑ motilità cellulare PROPOLI

Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol TGF -  Alterazioni morfologiche ↓ E - cadherin ↑ N - cadherin ↑ ROS ↑ motilità cellulare PROPOLI Se pretrattiamo con CAPE (ac. Caffeico) l’effetto è di minore intensità.

Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol The results of this study suggest that natural propolis extracts may prevent TGF-β1-induced EMT in alveolar cells, which may be clinically applied in the prevention and/or treatment of EMT-related fibrotic diseases as well as airway remodeling in chronic asthma