Distribution. ¿Where do drugs go?

Slides:

Advertisements

Similar presentations

TWO STEP EQUATIONS 1. SOLVE FOR X 2. DO THE ADDITION STEP FIRST

Advertisements

Chemical Quantities or

Karunya Kandimalla, Ph.D

Review for quiz on Wednesday

CHAPTER 4 INTRAVENOUS INFUSION.

PHARMACOKINETIC MODELS

Slide 1 Insert your own content. Slide 2 Insert your own content.

Solution Concentration Read 281 – 283. Try questions 1 – 8 (show work) Concentration = quantity of solute quantity of solution (not solvent) There are.

Copyright © 2003 Pearson Education, Inc. Slide 1 Computer Systems Organization & Architecture Chapters 8-12 John D. Carpinelli.

Copyright © 2011, Elsevier Inc. All rights reserved. Chapter 6 Author: Julia Richards and R. Scott Hawley.

Beat the Computer Drill Multiply 7s Becky Afghani, LBUSD Math Curriculum Office, 2004.

Multiplication Facts Review. 6 x 4 = 24 5 x 5 = 25.

FACTORING Think Distributive property backwards Work down, Show all steps ax + ay = a(x + y)

PP Test Review Sections 6-1 to 6-6

Introduction to Complex Numbers

Introduction to Complex Numbers Adding, Subtracting, Multiplying And Dividing Complex Numbers Mr. SHAHEEN AHMED GAHEEN. The Second Lecture.

1 DISTRIBUTION OF XENOBIOTICS I. GENERAL PRINCIPLES II. CNS DISTRIBUTION III. MATERNAL-FETAL DISTRIBUTION IV. DISTRIBUTION INTO BREAST MILK.

Copyright © 2012, Elsevier Inc. All rights Reserved. 1 Chapter 7 Modeling Structure with Blocks.

Clinical Pharmacokinetics

MaK_Full ahead loaded 1 Alarm Page Directory (F11)

Fluid, Electrolyte, and Acid-Base Imbalances

Research Summary 08/2010 Dr. Andrej Mošat` Prof. A. Linninger, Laboratory for Product and Process Design, M/C 063 University of Illinois at Chicago 04.

FIND THE AREA ( ROUND TO THE NEAREST TENTHS) 2.7 in 15 in in.

PSSA Preparation.

Physics for Scientists & Engineers, 3rd Edition

Copyright Tim Morris/St Stephen's School

DISTRIBUTION The body is a container in which a drug is distributed by blood (different flow to different organs) - but the body is not homogeneous. Factors.

BioavailabilityDistribution Absorption and Transport.

One-compartment open model: Intravenous bolus administration

SEMINAR ON VOLUME OF DISTRIBUTION BY SUMAN.THOTA M.PHARM 1 ST YEAR (1 ST SEM) INDUSTRIAL PHARMACY U.C.P.SC.

Diffusion Protein Mediated Diffusion integral membrane proteins transport proteins (transporters) –diffusion through hydrophilic channels –facilitated.

Pharmacology Department

Is the passage of drug from its site of administration to its site of action through cell membranes. Sites of Administration Sites of action Cell membrane.

Prof. Hanan Hagar Pharmacology Department. What student should know  Major body fluid compartments  Concept of compartments.  Apparent volume of distribution.

VM 8314 Dr. Jeff Wilcke Pharmacokinetic Modeling (describing what happens)

Prof. Hanan Hagar Pharmacology Department.  Is the fraction of unchanged drug that enters systemic circulation after administration and becomes available.

Pharmacokinetics Introduction

10/13/20151Prof. Mazen Qato. OBJECTIVES 10/13/2015Prof. Mazen Qato2.

How does water move in the body? The cell membrane is semi-permeable Water can move freely Water is in equilibrium between cells and extracellular fluids.

1 Pharmacology Pharmacokinetics –Absorption –Distribution –Biotransformation (metabolism) –Excretion Pharmacodynamics –Receptor binding –Signal transduction.

PHARMACOKINETIC MODELS

Drug distribution and protein binding

The General Concepts of Pharmacokinetics and Pharmacodynamics

1. Fate of drugs in the body 1.1 absorption 1.2 distribution - volume of distribution 1.3 elimination - clearance 2. The half-life and its uses 3. Repeated.

The Plasma Membrane – a Phospholipid Bilayer. Components of Plasma Membrane Lipids Proteins 1) Phospholipids 2) Cholesterol 3) Glycolipds 1) Peripheral.

Quantitative Pharmacokinetics

Pharmacology Department

Principles of pharmacokinetics Prof. Kršiak Department of Pharmacology, Third Faculty of Medicine, Charles University in Prague Cycle II, Subject: General.

Pharmacology Department

Dr. Rida Shabbir DPT KMU. Prolonged, heavy exerciseNormal ? Intake:  Fluids ingested (Drinking/in food)  From metabolism ?2300ml/dTotal.

Compartmental Models and Volume of Distribution

Pharmacokienetic Principles (2): Distribution of Drugs

Chapter 7: An-Najah National University Anatomy and Physiology 1

Chapter 7 COMPARTMENT MODELS

Lecture-8 Biopharmaceutics

Quantitative Pharmacokinetics

Pharmaceutics 2.

Bioavailability and distribution

Kinetics, Modeling Oct 19, 2009 Casarett and Doull,

به نام خدا فارماکوکینتیک نیمسال دوم دکتر ساسان زائری

Kinetics, Modeling Oct 15, 2006 Casarett and Doull,

School of Pharmacy, University of Nizwa

School of Pharmacy, University of Nizwa

Introduction to Pharmacology

Presentation transcript:

Distribution. ¿Where do drugs go? http://pharmamotion.com.ar

Volume of distribution Apparent and hypothetical volume in which the drug is dispersed. Why is it relevant? To calculate the loading dose of a drug http://pharmamotion.com.ar

Volume of distribution Relative size of various distribution volumes within a 70-kg individual Plasma: 4 liters. Interstitial volume: 10 liters. Intracelullar volume: 28 liters http://pharmamotion.com.ar

Plasma compartment Vd: around 5 L. Very high molecular weight drugs, ordrugs that bind to plasma proteins excesively Example: heparin 4L (3-5) http://pharmamotion.com.ar

Extracellular fluid Vd: between 4 and 14 L. Drugs that have a low molecular weight but are hydrophilic. Example Atracuronium 11 L (8-15) http://pharmamotion.com.ar

Vd equal or higher than total body water Diffusion to intracelullar fluid . Vd equal to total body water. Ethanol 38 L (34-41) Alfentanyl 56 L (35-77) Drug that binds strongly to tissues. Vd higher than total body water. Fentanyl: 280 L Propofol: 560 L Digoxin:385 L