Career Opportunities in the Life Sciences Career Opportunities in Biotechnology and Drug Development Career Opportunities in the Life Sciences Toby Beth Freedman, Ph.D. SEBA, October 12th, 2012 10-11 am www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved.

Transitioning from Academia to Industry Job search strategies Today’s Talk Career overview Transitioning from Academia to Industry Job search strategies If there is time, current economy www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 2 2

Definitions “Pharmaceuticals” Chemical synthesis “Small molecule drugs” Pfizer, BMS, Merck Aspirin, statins, Viagra, antibiotics, taxol, Prozac, antihistamines, anti-inflammatories

Definitions “Biotechnology” Biologics: DNA, RNA, protein, viruses, antibodies, hormones “Large molecule drugs” Genentech, Amgen, Genzyme, Gilead, Biogen Rituxan, EPO, Enbrel, Gleevec, Herceptin, insulin, HGF

Definitions: Biotechnology Also Biotools, Reagents & Services Instruments and tools, enabling technology, services Microscopes, reagents, software, services Affymetrix, Zeiss, Promega, Covance, BCG

Definitions “Medical Devices” Instrument or software for diagnosis or therapeutic purposes J&J, GE, Medtronic, Tyco, Philips, Boston Scientific, Abbott Stents, MRI, surgical equipment, defibrillators, wheelchairs

Biofuels Each box is many Ph.D.s of information Biotech versus pharma Teams Cost of developing products, high attrition rate

Definitions “Healthcare” Hospitals/HMOs, Insurance companies Kaiser, Sutter Health

Three Main Career Paths for Students Academia Government, Research Institutes, Non-Profits Industry CEO VP Tenured Professor Director or Other Dean Director Fellow or Principal Scientist Track Advocate Scientist or Other Manager Tenure track Educator Science and Business Student www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 9 9 9 9

Career choices for science and medical backgrounds My Experiment A comprehensive, systematic assessment of careers for life science professionals Not hypothesis driven Career choices for science and medical backgrounds Resource guide for career planning—so much information that readers identify a career that suits their skills, interests, goals and personality attributes www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 10 10

Goals: Be Sure To Enjoy a Job “If you are doing what you love, then it’s not really ‘work’” Peter David

Goals: Get on the Right Track

1 hour telephone informational interviews Mostly VPs, Ph.D.s or MDs Methods 200+ interviews 1 hour telephone informational interviews Mostly VPs, Ph.D.s or MDs 10 interviews per chapter Compiled, analyzed and summarized Took three years Published by Cold Spring Harbor Laboratory Press and is on Amazon www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 13 13

Results: So Many Careers To Choose! www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 14 14

Product Development Overview Preclinical Studies Commercial Operations and Sales Preclinical Studies Lead Optimization of Drug Candidates Clinical Trials NDA or BLA filing Discovery Research IND filing FDA review Product Launch! Bio/Chemical Process Development Scale-Up / Manufacturing Phase IIIB/IV Trials Discovery Research Clinical Development and Regulatory Affairs Medical Affairs Commercial Operations: Marketing, Sales, and Technical Support Chemical and Biological Development, Operations and Manufacturing, Quality www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 15 15 15 15

Careers for Engineers: Medical Device and Biotech Tools Companies Discovery Research Preclinical Research Recruiting Venture Capital & Banking Law Product Development Management Consulting Project Management Bio IT Services R&D Clinical Development Quality Operations Operations & Manufacturing Commercial Operations Regulatory Affairs Business Development Medical Affairs Corporate Communications Marketing Sales Product Support

Careers in Research www.careersbiotech.com 17 Discovery Research Preclinical Research Recruiting Venture Capital & Banking Law Bio/Pharmaceutical Product Development Management Consulting Project Management Bio IT Services R&D Clinical Development Quality Operations Commercial Operations Regulatory Affairs Operations & Manufacturing Business Development Medical Affairs Corporate Communications Marketing Sales Product Support www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 17 17

Having a business background is an advantage Discovery Research Preclinical Research Recruiting Law Venture Capital & Banking Bio/Pharmaceutical Product Development Management Consulting Project Management Bio IT Services R&D Clinical Development Quality Operations Operations & Manufacturing Commercial Operations Regulatory Affairs Business Development Medical Affairs Corporate Communications Marketing Sales Product Support www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 18 18

Do you want to be a CEO one day? Discovery Research Preclinical Research Recruiting Venture Capital & Banking Law Bio/Pharmaceutical Product Development Management Consulting Project Management Bio IT Services R&D Clinical Development Quality Operations Operations & Manufacturing Commercial Operations Regulatory Affairs Business Development Medical Affairs Corporate Communications Marketing Sales Product Support www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 19 19

Careers where you can earn the most money Discovery Research Preclinical Research Recruiting Venture Capital & Banking Law Bio/Pharmaceutical Product Development Management Consulting Project Management Bio IT Services R&D Clinical Development Quality Operations Commercial Operations Regulatory Affairs Operations & Manufacturing Business Development Medical Affairs Corporate Communications Marketing Sales Product Support www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 20 20

Hot Jobs www.careersbiotech.com 21 Discovery Research Preclinical Research Recruiting Venture Capital & Banking Law Bio/Pharmaceutical Product Development Management Consulting Project Management Bio-IT Services R&D Clinical Development Quality Operations Operations & Manufacturing Commercial Operations Regulatory Affairs Business Development Medical Affairs Corporate Communications Marketing Sales Product Support www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 21 21

Positions for students Analysts/Assoc Kauffman Fellow Portfolio, SRA Consultant Project coordinator Analyst Budget, strategy Quality systems Many Liaison --what’s hot what’s not -PM is a good career --most will go into DR and move around, most people will find that your interests change over time and you will want to explore new career areas --business interest? --interested in writing? Having children? Whatever your passion, there is hopefully something for you Analyst Marketing Marcom, AAAS Fellow Marketing, MR Tech Support, FAS Sales reps, trainers, managers www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 22 22

Positions for PhDs/Postdocs Patent agent, advisor, USPTO Scientist I Research Analysts/Assoc Kauffman Fellow Consultant Project coordinator Bioinformatics Medical writer, IT QC chemist Startups FDA, Liaison --what’s hot what’s not -PM is a good career --most will go into DR and move around, most people will find that your interests change over time and you will want to explore new career areas --business interest? --interested in writing? Having children? Whatever your passion, there is hopefully something for you OTT, Portfolio MSL, Scientific affairs Marcom, AAAS Fellow Market research Tech Support, FAS, Trainer Technical sales rep, FAS www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 23 23

So Many Careers To Choose! --what’s hot what’s not -PM is a good career --most will go into DR and move around, most people will find that your interests change over time and you will want to explore new career areas --business interest? --interested in writing? Having children? Whatever your passion, there is hopefully something for you www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 24 24

Many areas to consider Table 6-1: Biotechnology and Drug Development Overview... Where the Jobs Are Drug Discovery & Development Biotechnology “Tools” Biotechnology Services Other Pharma/ Biotech Areas Government Institutions Medical Devices Academia Pharmaceutical companies Biotechnology therapeutic Vaccines Drug delivery Molecular Diagnostics Reagents and Chemical suppliers Instruments (e.g., microscopes) Platform companies (e.g., genomics, proteomics, nanotechnology) Bio-IT Software and hardware diagnostics Management consulting and accounting firms Law firms Venture capital and investment banking Recruiting firms Contract research organizations (CROs) Contract manufacturers (CMOs) Research and clinical testing: clinical labs, customized antibodies Other agencies and niche providers: PR, advertising, market research, medical communications Consultants Agricultural Industrial biotechnology Molecular diagnostics Veterinary companies Foundations, non-profits, social philanthropy Clean tech/energy Nanotech Journalism Viticulture Food and Drug Administration (FDA) and CBER Centers for Disease Control (CDC) National Institutes of Health (NIH) US Patent and Trademark Office (USPTO) Research institutes and government labs Homeland security & defense CIA, FBI, and NASA Trade commissions Crime labs forensics Medical devices Diagnostic companies eHealth HC Informatics Telemedicine Tech transfer Industry-supported labs and institutes Education Program management Incubators Miscellaneous includes veterinary, industrial biotechnology, molecular dx, ab-bio www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 25 25

Careers in Healthcare www.careersbiotech.com Healthcare Practitioners Nursing Associated Careers and Therapists Technologists and Technicians Rehab Therapists Healthcare Administration Insurance Industry Physicians Chiropractors Dentists Optometrists Podiatrists Veterinarians Licensed nurses Registered nurses Nurse anesthetists Nurse midwives Nurse practitioners Home health aides Surgeon assistants Nurse’s aides Acupuncturists Audiologists Dental hygienists Dietitians and nutritionists Genetic counselors Pharmacists Psychologists Occupational therapists Opticians Orthotists and prosthetists Physical therapists Recreational therapists Respiratory therapists Pediatric occupational therapists Biomedical engineers Biomedical equipment techs Biomedical photographers Biomedical writers Child life specialists Dietary managers Geriatric social workers Anesthesiologists Blood bank techs Cardiovascular techs Radiology techs Clinical lab techs Cytotechnologists Cardiovascular Nuclear medicine Dental assistants Dental lab techs Diagnostic medical sonographers Diagnostic imaging Dietetic techs Electroencephalograph Emergency techs Paramedics Food techs Histology techs Ophthalmic techs Optometric techs Perfusionists Phlebotomists Pulmonary techs Radiation therapy techs Surgical techs Veterinary assistants Art therapists Certified athletic trainers Dance movement Music therapists Patient reps Psychiatric aides Rehab counselors Social services aides Speech language pathologists Substance abuse counselors Admitting officers Accounting and finance Coordinators of health wellness Environmental health and safety Food service Health education Health information technologists Human resources Librarians Public relations Nursing home directors QA directors Geriatric care managers Medical records Medical billing, claims, patient accounting Medical secretaries Mental health workers Administration Actuaries Agents and brokers Claims adjusters Loss control specialists Medical insurance billing and coding reps Medical claims reviewers Service reps Sales and marketing Underwriters Miscellaneous includes veterinary, industrial biotechnology, molecular dx, ab-bio www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 26 26

Values/Goals$$$/Market Ideal Job Skills Interests Ideal Job Values/Goals$$$/Market www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 27 27

About the Life Sciences Industry In 1982, Synthetic Insulin, produced by Eli Lilly and Genentech. This was the first ever approved genetically engineered human therapeutic. Image: Wikipedia Commons www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 28 28

Drug Development: A Risky Endeavor Commercial Operations and Sales Preclinical Studies Lead Optimization of Drug Candidates Clinical Trials NDA or BLA filing Discovery Research IND filing FDA review Product Launch! Bio/Chemical Process Development Scale-Up / Manufacturing Phase IIIB/IV Trials Discovery Research Preclinical Studies Clinical Development and Regulatory Affairs Millions of compounds 71-2 1 in 10 About 15 years and > $1B!

Career Paths in the Life Sciences Photo: Wikipedia Commons www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 30 30 30 30

Career Ladder in Discovery Research for Research Associates SRA SRA SRA SRA Research Associate Student www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 31 31

Career Ladder in Discovery Research: Ph.D.s are not technicians CEO VP R&D VP Research or CSO Director Fellow or Principal Scientist Track Group Leader Scientist I - III Postdoc www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 32 32

Career Potential in Discovery Research CEO Consultant Venture Capital Patent Law VP R&D or CSO Project Management Preclinical Research Regulatory or Clinical Affairs Quality Discovery Research Other Areas: Operations, Business Development, Marketing, Sales, Tech Support, Product Development Academia www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 33 33

Going from Academia to Industry Image: Wikipedia Commons

What you can do now to make yourself more marketable Human disease rather than basic research Hot therapeutic areas of interest to industry “Unmet medical needs” Same techniques, drug screens, applied science Patent your work Gain business understanding Gain understanding of clinical development www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 35 35

What you can do now -- continued Collaborate with industry cohorts Informational interviews Industry postdoc Follow biotech news Publish, publish, publish (but don’t perish) Presentations and attend conferences and become a perceived expert (get visibility) Consider FAS, MSL, Tech Support, Trainer Attend industry events, network and start early www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 36 36

Land a job on the business side Work at the OTTBD Visit Haas MBA program—management consulting firms, career coaching Business classes Join a startup at QB3 Entrepreneurial classes—CBE, QB3 series Entrepreneur chapter Talk to profs who consult or founders www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 37 37

What you can do now to land a job on the business side--continued Follow the biotech stock Invest in public companies—demonstrate financial acumen Show leadership—start something, run a program, be a President Pubs not needed in business Read WSJ, follow biotech business news www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 38 38

Making the Leap to Industry Industry postdoc MBT programs, KGI, JHU, SJSU Keck Institute’s Postdoc Professional Master’s Program (PPM) Certificates, classes @ UC Berkeley X and UCSC X Additional degrees: MBA, MPH, JD Volunteer/intern Network www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 39 39

Jobs in Industry

Looking for a job can be a full time job Job search strategies Looking for a job can be a full time job Apply to jobs that interest you Apply to jobs that will get you in the door The more you interview, the more likely you will find the most appealing job www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 41 41

Genentech Scientist I requirements Jobs in Industry Difficult job market--large numbers of industry professionals seeking employment Genentech Scientist I requirements www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 42 42

Build Your Network! www.careersbiotech.com 43 Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 43 43

Why networking is so effective Someone that you know refers you to a job opportunity The more people you know, the greater your chances of being contacted or finding out about an opportunity Personally-vouched for candidates www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 44 44

Local places to network Local and national conferences Local biopharma societies, trade associations AWIS WIB ACRP AAAS You name it, there is a society www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 45 45

Networking Photo from Wikipedia www.careersbiotech.com 46 Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 46 46

The Art of Networking It’s a two-way street. Be helpful, ask questions about the other person, ask “what can I do for you?” www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 47 47

Scanning the audience looking for other people to talk to Networking No-No’s Can you get me a job? Are there any job openings in your company? (what can you say instead?) Scanning the audience looking for other people to talk to Ask a question and then walk away Looking desperate “I have to get a drink—I’ll be right back” ditch www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 48 48

Using LinkedIn LinkedIn.com: recruiters use it The greater your LinkedIn network, the more access you have LinkIn with LIONs and power users Join LinkedIn groups, alumni organizations Include key words, therapeutic areas to interest recruiters Email address or way to be contacted Keep professional Jobs are on site and groups MySpace, Facebook: set on private www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 49 49

Networking on the Internet Google “therapeutic area conference” Contact speakers, authors Search LinkedIn in specific companies that interest you for people that you might know Professors who consult/founders Contact alumni www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 50 50

“Shop” for a Job on the Internet Job posting sites www.biospace.com www.craigslist.org www.audreysnetwork.com www.careersbiotech.com www.indeed.com www.ventureloop.com Professional societies Therapeutic areas and functional areas, i.e. immunology, neurosciences, oncology, marketing, business development www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 51 51

Let the jobs find you Resume posting sites www.biospace.com www.indeed.com www.medzilla.com www.monster.com www.execunet.com www.bio2devicegroup.org www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 52 52

BioSpace, www.biospace.com Campus Career Fairs Society meetings, i.e. ASCB, AAAS, www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 53 53

Trade Shows at Scientific Conferences BIO, www.bio.org the biggest InformEx, Chemistry www.informex.com ASCB, www.ascb.org Interphex, manufacturing, www.interphex.com Tri-Molecular, www.tri-conference.com www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 54 54

Career counselors and services On campus, medical schools, business, law programs Alumni school counselors usually free Off campus www.edd.org, www.jvs.org, www.thejobforum.org, NOVA, ProMatch, Peninsula Works, EastBay Works, free interview coaching and resume preparation www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 55 55

Free Biotechnology News BioSpace www.biospace.com Biospace careers insider BayBiotechReview www.baybiotechreview.com FierceBiotech www.fiercebiotech.com FierceBioResearch www.fiercebioresearcher.com OnBioVC www.onbiovc.com The IN VIVO Blog Nature Biotechnology www.nature.com/nbt/ The Scientist www.the-scientist.com Biotechnology Industry Organization www.bio.org www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 56 56

Resumes Image: Wikipedia As a team you are able to accomplish more than an individual researcher Image: Wikipedia

Resumes: how to stand out Prepare for the 5 second scan Align skills with the position specs Highlight and show how you fit the position Add key words, therapeutic areas www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 58 58

Tips for submitting your resume to large companies Job requisition number Career objective Apply directly on the company’s website Network, network, network! www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 59 59

Working with Recruiters They know about positions that may not be posted on the Internet—the “hidden” job market They will get your resume in front of the hiring manager www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 60 60

Working with Recruiters Recruiters are paid by the company You are your own best job agent www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 61 61

Interviewing www.careersbiotech.com 62 Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 62 62

The Art of Interviewing You’ve already pass the technical test—corporate match Research the company Don’t interview like a postdoc! www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 63 63

Good Interviewing Books Knock em dead 101 Great Answers to the Toughest Interview Questions 301 Smart Answers to Tough Interview Questions And by the way, you should do the same thing. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 64 64

The Current Economy Each box is many Ph.D.s of information Biotech versus pharma Teams Cost of developing products, high attrition rate

The current economy: “The Times, They are a Changin’” 2008 was a bad year 2009 was a *terrible* year It’s a little better now 3 IPOs in 2009, 13 IPOs in 2010, 10 IPOs in 2011, lackluster receptions Overall biotech sector was down Social media hot, 3.3% unemployment www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 66 66 66 66

Monster Report on Biotech Jobs 2011 Job postings in biotech positive expansion 2011 Hottest area: clinical lab techs and technicians 40% Areas hiring most (volume posting): Texas, NC, Kentucky, Michigan, NJ, RH www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 67 67 67 67

In High Demand Regulatory affairs Sales CLIA-certification Bioreactors QA and QC Rare skills, i.e. ephiz www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 68 68 68 68

Successful biopharmas Service companies, i.e. CROs and CMOs Where are the jobs? Academia Successful biopharmas Service companies, i.e. CROs and CMOs Biofuels (bioreactors, fermentation, microbiology, plant genetics (agbio)) Small venture-backed companies www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 69 69

43,000 layoffs in big pharma in 2010 Top 5 lay-offs in 2011 Pfizer – 4,220 Novartis – 2,000 Abbott Labs – 1,900 AstraZeneca – 1,550 Sanofi – 700+ 43,000 layoffs in big pharma in 2010 Source: www.fiercebiotech.com, December 9, 2011 www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 70 70 70 70

Merck/Schering Plough – 16,000 J&J – 8,900 Astra Zeneca – 7,400 Top 5 lay-offs in 2009 Pfizer/Wyeth – 19,500 Merck/Schering Plough – 16,000 J&J – 8,900 Astra Zeneca – 7,400 GlaxoSmithKline – 6,000 Source: www.fiercebiotech.com, December 9, 2009 www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 71 71 71 71

Venture capital and capital markets ROI for LS VCs was -1.5% in 2010 Less VCs, less money, smaller investments Difficult for startups to raise money Public markets less interested in LS, IPO window lackluster VCs investing in later stage deals Corporate venture, academia-industry partnerships www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 72 72 72 72

M&As are bad for industry 30 mergers over last 60 years didn’t boost productivity More companies = more successful drugs New areas of pharmacology most successful 25% fewer public biotechs in 2010 than 3 years ago Bernard Munos/Forbes 2011 www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 73 73 73 73

The FDA… Overburdened with added responsibilities Increasingly focused less on benefits and more on possible risks Average review times increasing Regulatory environment raises “serious barriers to innovation” CHI Report, 2011 CHI 2011 www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 74 74 74 74

Consequences of the FDA… Difficult to raise money—regulatory risks and uncertainty Dramatic shift in clinical trials US to Europe Rise in number of drugs approved in EU first EU Docs learn new tech first Costs of RA and consultants going up Operations, experts move overseas CHI Report, 2011 CHI 2011 www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 75 75 75 75

The Scenario at Big Pharma… Dismal internal R&D returns Cost per successful drug has risen (cost of R&D has gone up, shorter periods of economic returns due to generics and patent life span, declining productivity) Regulatory hurdles higher www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 76 76

Big pharma solution: outsource R&D to biotech “Externalize” small mol discovery research, pre-Phase III compounds, particularly for riskier therapeutic areas (NR, COPD, Cardio) Reduction in R&D research and reallocating resources to in-license deals with biotechs Move from R&D to “Search & Development” orgs Reduces investment risk Biotechs expected to become pharma’s main R&D engine www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 77 77

Reason for biopharma to outsource: develop presence overseas Pursue a market presence China expected to be third largest Rx market by 2013, number two in 2020 Growing markets Australia, S. Korea, India, Vietnam, Japan, Russia Cost of dev is 1/5 to 1/3rd, labor costs are rapidly rising Serendipity lost www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 78 78

Outsourcing and impact on jobs Chemistry and manufacturing overseas Small molecule, devices, large mol safer Clinical trials, preclinical, research and IT Virtual companies= growth in services and consultants Still need quality and PM Global leadership www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 79 79 79 79

Biotech and medical devices better than other industries Not so bad off… Biotech and medical devices better than other industries Big biotech is doing well Big pharma is cash rich, patents expiring, need to fill pipelines www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 80 80 80 80

VCs are Funding Biotech and Medical Device Companies Source: PricewaterhouseCoopers, Money Tree Report, www.pwcmoneytree.com

Northwest Funding Source: PricewaterhouseCoopers, Money Tree Report, www.pwcmoneytree.com

History of VC Funding in Biotech Source: PricewaterhouseCoopers, Money Tree Report, www.pwcmoneytree.com

Hot growth potential sectors: new and emerging areas Healthcare, surgery centers Generics and biosimilars Biofuels and green/clean tech, grey water, energy Personalized medicine/companion Dx Combination therapies HC IT, telemedicine, mobile HC apps, “doc-in-the-box” www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 84 84 84 84

Healthcare informatics (i.e. electronic health records) Trend to transition to electronic data capture in just about every job function Healthcare informatics (i.e. electronic health records) Laboratory automation Bioinformatics (personalized medicine) Data management, bio-IT Regulatory affairs, i.e. electronic filing Discovery research, i.e. eNotebooks Intersection of life and computer sciences training www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 85 85 85 85

The Future of the Life Sciences Remains Promising Significant unmet medical needs remain—neurological disorders, cancer, infectious diseases, diabetes, obesity, cardiovascular diseases People are living longer, aging population all over the world Tremendous market opportunity in China, India and other emerging countries Energy www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 86 86 86 86

Recommendations for job search during difficult economic times Non-glamorous jobs Temp-to-hire/contract ops Safety in biotech hubs: SF, SD, Boston, Seattle Good time to start a company Start networking early www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 87 87

Conclusions Over >100 different careers in academia, industry and government Many different industries in which to work Find the vocation that best suits your interests, skills and goals Do what you love Not money or a fad Be flexible about job search--your first job will not be your last

Find your niche

Recommended Academia Career Books At the Bench and At the Helm, Kathy Barker, CSHLP Advice for New Faculty Members, Robert Boice Making the Right Moves: A Practical Guide to Scientific Management for Postdocs and New Faculty, Burroughs Wellcome Fund, HHMI, www.hhmi.org/labmanagement Lab Dynamics: Management Skills for Scientists, Carl and Suzanne Cohen, CSHLP Managing Scientists, Alice Sapienza www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 90 90 90 90

Recommended Industry Books Science Lessons, Gordon Binder, Former CEO of Amgen Emperor of All Maladies, Siddhartha Mukherjee Put Your Science to Work, Peter Fiske Career Opportunities in Clinical Drug Research, Rebecca Anderson Nontraditional Careers for Chemists, Lisa Balbes Alternative Careers in Science, Cynthia Robbins-Roth www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 91 91 91 91

Book Information Careers in Biotechnology and Drug Development Published by Cold Spring Harbor Laboratory Press Books available on Amazon and www.cshlpress.org Paperbacks selling for $35 Hard covers selling for $47 Available in German www.careersbiotech.com www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 92 92

Additional Information Free sample chapter on Careers in Project Management, www.careersbiotech.com List of job posting sites under career resources at www.careersbiotech.com www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 93 93 93 93

President, Synapsis Search Contact Information Toby Freedman, Ph.D. President, Synapsis Search Recruiting in the life sciences: Biotechnology, Biofuels, Services, Non-Profits www.synapsissearch.com toby@synapsissearch.com www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 94 94 94 94

Acknowledgments Over 200+ industry professionals Special Thanks to: Molly Schmid, Joseph Carlino, Betsy Alberty, Angelie Agarwal, Bill Lindstaedt Even More Special Thanks to: My father, Bill Freedman, who edited the chapters multiple times and Peter Symonds www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 95 95 95 95

Thank you! Start companies, be successful, and find a cure for cancer! www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 96 96 96 96

So Many Careers To Choose! --what’s hot what’s not -PM is a good career --most will go into DR and move around, most people will find that your interests change over time and you will want to explore new career areas --business interest? --interested in writing? Having children? Whatever your passion, there is hopefully something for you www.careersbiotech.com Copyright © 2007 Career Opportunities in Biotechnology and Drug Development. All rights reserved. 97 97