Jochen Utikal, MD, Adina Thoelke, MD, Jürgen C

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Local cutaneous argyria mimicking melanoma metastases in a patient with disseminated melanoma Jochen Utikal, MD, Adina Thoelke, MD, Jürgen C. Becker, MD, PhD, Robert Figl, MD, Sergij Goerdt, MD, Dirk Schadendorf, MD, Selma Ugurel, MD Journal of the American Academy of Dermatology Volume 55, Issue 5, Pages S92-S94 (November 2006) DOI: 10.1016/j.jaad.2005.10.062 Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 A, Blue-black macules and papules on lower aspect of left leg in patient with metastasized melanoma diagnosed as local cutaneous argyria. B, Macules and papules on left leg of same patient diagnosed as cutaneous melanoma metastases. C and D, Hematoxin-eosin stain of papular lesion from lower aspect of left leg shows parakeratosis and extensive deposition of small granules in corneal layer. (Original magnifications: ×5 and ×20, respectively.) E and F, Staining for Mart-1 was positive in solitary melanocytes of basal layer, but not in granules of corneal layer. (Original magnification: ×20.) G, Melanin staining of corneal layer was negative. (Original magnification: ×20.) H, High resolution of corneal layer shows no iron staining of granules. (Original magnification: ×20.) Journal of the American Academy of Dermatology 2006 55, S92-S94DOI: (10.1016/j.jaad.2005.10.062) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions