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Pigmentation after using topical tacrolimus to treat lichen sclerosus: Possible role of stem cell factor  Young Jin Kim, MD, Hee Young Kang, MD, PhD 

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Presentation on theme: "Pigmentation after using topical tacrolimus to treat lichen sclerosus: Possible role of stem cell factor  Young Jin Kim, MD, Hee Young Kang, MD, PhD "— Presentation transcript:

1 Pigmentation after using topical tacrolimus to treat lichen sclerosus: Possible role of stem cell factor  Young Jin Kim, MD, Hee Young Kang, MD, PhD  Journal of the American Academy of Dermatology  Volume 57, Issue 5, Pages S125-S127 (November 2007) DOI: /j.jaad Copyright © 2007 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 A, Hypopigmented patch on right cheek. B, After 3 months of therapy, brownish pigmentation localized at site of tacrolimus application. Journal of the American Academy of Dermatology  , S125-S127DOI: ( /j.jaad ) Copyright © 2007 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Histopathologic and immunohistochemical findings of hyperpigmented skin after tacrolimus use were compared with previous hypopigmented and normal skin. (A-C, Hematoxylin-eosin stain; original magnification: ×100). Fontana-Masson stain (D-F), NKI/beteb detection of epidermal melanocytes (G-I), and reactions with antibodies to stem cell factor (J-L) and vimentin (M-O) are shown. (D-O, Original magnifications: ×200.) Journal of the American Academy of Dermatology  , S125-S127DOI: ( /j.jaad ) Copyright © 2007 American Academy of Dermatology, Inc. Terms and Conditions

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