Randy M. Stevens, MD, M. Salik Jahania, MD, Robert M

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Presentation transcript:

Sodium-hydrogen exchange inhibition attenuates in vivo porcine myocardial stunning Randy M. Stevens, MD, M. Salik Jahania, MD, Robert M. Mentzer, MD, Robert D. Lasley, PhD The Annals of Thoracic Surgery Volume 77, Issue 2, Pages 651-657 (February 2004) DOI: 10.1016/S0003-4975(03)01355-9

Fig 1 The effects of cariporide treatment (1 mg/kg, IV) on left anterior descending coronary artery segment shortening (SS) and preload recruitable stroke work area (PRSWA) before ischemia. Baseline SS and PRSWA measurements were made 30 minutes after completion of instrumentation. Responses to cariporide were recorded 5 minutes after administration of cariporide. The Annals of Thoracic Surgery 2004 77, 651-657DOI: (10.1016/S0003-4975(03)01355-9)

Fig 2 The recovery of segment shortening (SS) during reperfusion following 15 minutes of left anterior descending coronary artery occlusion. Results are expressed as percent of preischemic (PreISC) values. Values are mean ± the standard error of the mean (*p < 0.05 versus control group). The Annals of Thoracic Surgery 2004 77, 651-657DOI: (10.1016/S0003-4975(03)01355-9)

Fig 3 The effects of cariporide treatment before ischemia on the recovery of left anterior descending coronary artery stroke work (SW). Results are expressed as percent of preischemic (PreISC) values. Values are mean ± the standard error of the mean (*p < 0.05 versus control group). The Annals of Thoracic Surgery 2004 77, 651-657DOI: (10.1016/S0003-4975(03)01355-9)

Fig 4 Reperfusion recovery of left anterior descending coronary artery bed preload recruitable stroke work (PRSW). Results are expressed as percent of preischemic (PreISC) values. Values are mean ± the standard error of the mean (*p < 0.05 versus control group). The Annals of Thoracic Surgery 2004 77, 651-657DOI: (10.1016/S0003-4975(03)01355-9)

Fig 5 The effect of 15 minutes of coronary occlusion and 3 hours of reperfusion on left anterior descending coronary artery bed preload recruitable stroke work area (PRSWA). Results are expressed as percent of preischemic (PreISC) values. Values are mean ± the standard error of the mean (*p < 0.05 versus control group). The Annals of Thoracic Surgery 2004 77, 651-657DOI: (10.1016/S0003-4975(03)01355-9)