Inhibition of the pacemaker current: a bradycardic therapy for off-pump coronary operations Alain Bel, MD, Louis P Perrault, MD, PhD, Bouchaib Faris,

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Presentation transcript:

Inhibition of the pacemaker current: a bradycardic therapy for off-pump coronary operations Alain Bel, MD, Louis P Perrault, MD, PhD, Bouchaib Faris, MD, Christian Mouas, Jean-Paul Vilaine, MD, Philippe Menasché, MD, PhD The Annals of Thoracic Surgery Volume 66, Issue 1, Pages 148-152 (July 1998) DOI: 10.1016/S0003-4975(98)00346-4

Fig 1 Comparative effects of the drugs on heart rate. (A) Values at the end of the 60-minute period of drug infusion (∗p < 0.02 versus control, p < 0.03 versus E high, p < 0.0007 versus E low, p < 0.0001 versus N high and low). (B) Pooled values over the 60-minute period of postdrug perfusion (∗p < 0.0001 versus all groups). Values are given as mean ± standard error of the mean. Each group consisted of eight hearts. (C = control (untreated) group; K+ = potassium arrest; E high = esmolol high dose (6 × 10−3 mol/L); E low = esmolol low dose (3 × 10−4 mol/L); N high = nicorandil high dose (10−3 mol/L); N low = nicorandil low dose (10−5 mol/L); S = S 16257-2 (3 × 10−6 mol/L).) The Annals of Thoracic Surgery 1998 66, 148-152DOI: (10.1016/S0003-4975(98)00346-4)

Fig 2 Comparative effects of the drugs on left ventricular diastolic pressure. (A) Values at the end of the 60-minute period of drug infusion (∗p < 0.0001 versus all groups; #p < 0.04 versus N high, p < 0.02 versus N low, p < 0.003 versus S). (B) Pooled values over the 60-minute period of postdrug perfusion (∗p < 0.0001 versus all groups; #p < 0.0001 versus all groups). Values are given as mean ± standard error of the mean. Each group consisted of eight hearts. (C = control (untreated) group; K+ = potassium arrest; E high = esmolol high dose (6 × 10−3 mol/L); E low = esmolol low dose (3 × 10−4 mol/L); N high = nicorandil high dose (10−3 mol/L); N low = nicorandil low dose (10−5 mol/L); S = S 16257-2 (3 × 10−6 mol/L).) The Annals of Thoracic Surgery 1998 66, 148-152DOI: (10.1016/S0003-4975(98)00346-4)