A randomized clinical trial of regional cerebral perfusion versus deep hypothermic circulatory arrest: Outcomes for infants with functional single ventricle

Slides:

Advertisements

Similar presentations

Manuel J. Antunes, MD, PhD, DSc

Advertisements

Definition of proximal anastomosis in the doors study

A study of brain protection during total arch replacement comparing antegrade cerebral perfusion versus hypothermic circulatory arrest, with or without.

The quest to optimize neurodevelopmental outcomes in neonatal arch reconstruction: The perfusion techniques we use and why we believe in them Richard.

The improvement of hypoxia correlates with neuroanatomic and developmental outcomes: Comparison of midterm outcomes in infants with transposition of the.

Meena Nathan, MD, Lynn A. Sleeper, ScD, Richard G. Ohye, MD, Peter C

Right internal thoracic artery or saphenous vein grafting

Derrick Y. Tam, MD, Stephen E. Fremes, MD, MSc, FRCSC, FACP, FACC

Juan A. Crestanello, MD, Richard C. Daly, MD

The effect of hematocrit during hypothermic cardiopulmonary bypass in infant heart surgery: Results from the combined Boston hematocrit trials David.

Lower graft patency after off-pump than on-pump coronary artery bypass grafting: An updated meta-analysis of randomized trials Hisato Takagi, MD, PhD,

A randomized comparison of the Saphenous Vein Versus Right Internal Thoracic Artery as a Y-Composite Graft (SAVE RITA) trial: Early results Ho Young.

Defining operative mortality: Impact on outcome reporting

Surgery for acute type A aortic dissection

Options for arterial cannulation to provide antegrade cerebral perfusion: Everything old is new again Joseph S. Coselli, MD, Ourania Preventza, MD The.

Victor van Berkel, MD, PhD

Comparison of neurologic outcome after deep hypothermic circulatory arrest with alpha- stat and pH-stat cardiopulmonary bypass in newborn pigs Margaret.

Multilevel data analysis: What? Why? How?

Harold L. Lazar, MD The Journal of Thoracic and Cardiovascular Surgery

Transcranial Doppler ultrasonography: A reliable method of monitoring pulsatile flow during cardiopulmonary bypass in infants and young children Ashley.

Similar cerebral protective effectiveness of antegrade and retrograde cerebral perfusion combined with deep hypothermia circulatory arrest in aortic arch.

The lord of the rings Antonio Miceli, MD, PhD

Surgical economics: MACRA, MIPS, and bundles—Lessons learned in the first 3 years of a coronary artery bypass grafting alternative payment model Daniel.

Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery Jane W. Newburger, MD, MPH, Richard A.

Increasing duration of circulatory arrest, but not antegrade cerebral perfusion, prolongs postoperative recovery after neonatal cardiac surgery Selma.

Clinical outcome score predicts the need for neurodevelopmental intervention after infant heart surgery Andrew S. Mackie, MD, SM, Gwen Y. Alton, RN,

John A. Elefteriades, MD, PhD (hon), Bulat A. Ziganshin, MD, PhD

Near-infrared spectroscopy: What we know and what we need to know—A systematic review of the congenital heart disease literature Jennifer C. Hirsch,

Direct innominate artery cannulation for selective antegrade cerebral perfusion during deep hypothermic circulatory arrest in aortic surgery Vinay Garg,

Innovation and science: The future of valve design

Tom Waterbury, MPS, CCP, LP, Thomas J

It's not “just a shunt” but sometimes it should be…

A first start for lung transplantation?

Early childhood health, growth, and neurodevelopmental outcomes after complete repair of total anomalous pulmonary venous connection at 6 weeks or younger

Effects of perfusion mode on regional and global organ blood flow in a neonatal piglet model Akif Ündar, PhD, Takafumi Masai, MD, Shuang-Qiang Yang,

The Journal of Thoracic and Cardiovascular Surgery

Chronic obstructive pulmonary disease severity influences outcomes after off-pump coronary artery bypass Benjamin Medalion, MD, Michael G. Katz, MD,

Patient characteristics are important determinants of neurodevelopmental outcome at one year of age after neonatal and infant cardiac surgery J. William.

A novel protocol of retrograde cerebral perfusion with intermittent pressure augmentation for brain protection Kazuo Kitahori, MD, Shinichi Takamoto,

Innominate artery cannulation: The Toronto technique for antegrade cerebral perfusion in aortic arch reconstruction—a clinical trial opportunity for the.

Living without lungs? Bilateral pneumonectomy and dual circulatory support: A step forward in the search for a total artificial lung Christian A. Bermudez,

Perfusion and repair technique in acute aortic dissection with cerebral malperfusion and damage of the innominate artery Paul P. Urbanski, MD, PhD, Matthias.

Instrumental variable methods in clinical research

Hisato Takagi, MD, PhD, Takuya Umemoto, MD, PhD

Attachment disorder in thoracoabdominal surgery

Straight deep hypothermic circulatory arrest for cerebral protection during aortic arch surgery: Safe and effective Bulat A. Ziganshin, MD, Bijoy G.

Marc Licker, MD, John Diaper, RA

Antegrade versus retrograde cerebral perfusion for hemiarch replacement with deep hypothermic circulatory arrest: Does it matter? A propensity-matched.

Passing the torch The Journal of Thoracic and Cardiovascular Surgery

The thoracoabdominal saga and heroes

Effects of moderate versus deep hypothermic circulatory arrest and selective cerebral perfusion on cerebrospinal fluid proteomic profiles in a piglet.

Treatment of deep sternal wound infections after coronary artery bypass grafting by means of injection of platelet gel: An evolving technology Erez Kachel,

Deep hypothermic circulatory arrest during the arterial switch operation is associated with reduction in cerebral oxygen extraction but no increase in.

The limits of detectable cerebral perfusion by transcranial doppler sonography in neonates undergoing deep hypothermic low-flow cardiopulmonary bypass

First nights, the adrenal axis, and steroids

The origins of open heart surgery at the University of Minnesota 1951 to 1956 Richard A. DeWall, MD The Journal of Thoracic and Cardiovascular Surgery

The Journal of Thoracic and Cardiovascular Surgery

Discussion The Journal of Thoracic and Cardiovascular Surgery

The future of cardiac surgery training: A survival guide

Increasing duration of deep hypothermic circulatory arrest is associated with an increased incidence of postoperative electroencephalographic seizures

“The more things change…”: The challenges ahead

Managing conflicts of interest

More than vital: Who bears the burden?

Apples remain apples NO matter what

Preoperative PFTs: The answer is blowing in the wind

National trends in utilization and in-hospital outcomes of mechanical versus bioprosthetic aortic valve replacements Abby J. Isaacs, MS, Jeffrey Shuhaiber,

Sunjay Kaushal, MD, PhD, Brody Wehman, MD

Journal changes and initiatives

A prospective randomized study of neurocognitive function and S-100 protein after antegrade or retrograde brain perfusion with hypothermic arrest for.

Edward Y. Chan, MD, Michael J. Reardon, MD

Presentation transcript:

A randomized clinical trial of regional cerebral perfusion versus deep hypothermic circulatory arrest: Outcomes for infants with functional single ventricle Caren S. Goldberg, MD, Edward L. Bove, MD, Eric J. Devaney, MD, Eileen Mollen, PhD, Edward Schwartz, PhD, Shauna Tindall, PhD, Cheryl Nowak, RN, John Charpie, MD, Morton B. Brown, PhD, Tom J. Kulik, MD, Richard G. Ohye, MD The Journal of Thoracic and Cardiovascular Surgery Volume 133, Issue 4, Pages 880-887.e1 (April 2007) DOI: 10.1016/j.jtcvs.2006.11.029 Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 llustration of RCP. Arrows represent flow of blood from cardiopulmonary bypass circuit through polytetrafluoroethylene graft anastomosed to the innominate artery. RCP, regional cerebral perfusion. The Journal of Thoracic and Cardiovascular Surgery 2007 133, 880-887.e1DOI: (10.1016/j.jtcvs.2006.11.029) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Survival for the RCP and DHCA treatment groups at hospital discharge after Norwood operation, to second-stage operation, and to 1 year of age. RCP, retrograde cerebral perfusion; DHCA, deep hypothermic circulatory arrest. The Journal of Thoracic and Cardiovascular Surgery 2007 133, 880-887.e1DOI: (10.1016/j.jtcvs.2006.11.029) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 PDI and MDI scores are plotted on the y-axis compared with MDI scores on the x-axis at pre–second stage (A) and at 1 year (B). PDI, Psychomotor Development Index; MDI, Mental Development Index. The Journal of Thoracic and Cardiovascular Surgery 2007 133, 880-887.e1DOI: (10.1016/j.jtcvs.2006.11.029) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 Box plots demonstrate comparison of DHCA and RCP groups for PDI pre–second stage (A), MDI pre–second stage (B), PDI at 1 year (C), and MDI at 1 year (D). DHCA, deep hypothermic circulatory arrest; RCP, regional cerebral perfusion; PDI, Psychomotor Development Index; MDI, Mental Development Index. The Journal of Thoracic and Cardiovascular Surgery 2007 133, 880-887.e1DOI: (10.1016/j.jtcvs.2006.11.029) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions