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Effects of moderate versus deep hypothermic circulatory arrest and selective cerebral perfusion on cerebrospinal fluid proteomic profiles in a piglet.

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Presentation on theme: "Effects of moderate versus deep hypothermic circulatory arrest and selective cerebral perfusion on cerebrospinal fluid proteomic profiles in a piglet."— Presentation transcript:

1 Effects of moderate versus deep hypothermic circulatory arrest and selective cerebral perfusion on cerebrospinal fluid proteomic profiles in a piglet model of cardiopulmonary bypass  Taslim Allibhai, MD, Robert DiGeronimo, MD, John Whitin, PhD, Jorge Salazar, MD, Tom To-Sang Yu, Xuefeng Bruce Ling, PhD, Harvey Cohen, MD, PhD, Patricia Dixon, Ashima Madan, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 138, Issue 6, Pages (December 2009) DOI: /j.jtcvs Copyright © Terms and Conditions

2 Figure 1 CSF/serum protein ratio (n = 5/group). Data are presented as a box plot showing median line and 25th and 75th percentiles, respectively. Group 1 = 18°C HCA without SCP; group 2 = 18°C HCA with SCP; and group 3 = 25°C HCA with SCP. A, P < .01 versus control; b, P < .05 versus 18°C SCP. CSF, Cerebrospinal fluid; HCA, hypothermic circulatory arrest; SCP, selective cerebral perfusion. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © Terms and Conditions

3 Figure 2 Averaged spectra for the control group obtained using the three acquisition modes of the mass spectrometer, optimized for small, medium, and large proteins The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © Terms and Conditions

4 Figure 3 Venn diagram representing the relationship between the significantly different peaks from each of the three surgical groups compared with controls. Group 1 = 18°C HCA (hypothermic circulatory arrest) without SCP (selective cerebral perfusion); group 2 = 18°C HCA with SCP; and group 3 = 25°C HCA with SCP. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © Terms and Conditions


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