Overexpression of DDB2 reduces invasive abilities in lungs of aggressive breast tumor cells. Overexpression of DDB2 reduces invasive abilities in lungs.

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Overexpression of DDB2 reduces invasive abilities in lungs of aggressive breast tumor cells. Overexpression of DDB2 reduces invasive abilities in lungs of aggressive breast tumor cells. Quantification by flow cytometry analysis of GFP-expressing and -invading cells in lungs from Nude mice injected (A) or xenografted (B) subcutaneously with GFP- and DDB2-overexpressing cells or established tumors, respectively. Data expressed as percentage of GFP-positive cells are mean ± SEM. Quantification by histologic analysis of invasive cells in lungs from mice injected (C) or xenografted (D) subcutaneously with DDB2-overexpressing cells or established tumors, respectively. Representative micrographs showing invasive breast tumor cells (in black) detected by in situ hybridization using human fragmented DNA as the probe. Bars represent 200 μm and black arrows indicate invasive MDA-DDB2 cl1 cells. Data are presented as mean number ± SEM of cells per mm2 infiltrated lungs per animal (n, number of animals). Statistical significance (P < 0.05) between DDB2-overexpressing MDA-MB231 cells and control cells. Marie Ennen et al. Cancer Res 2013;73:5040-5052 ©2013 by American Association for Cancer Research