GWIS: Genome-Wide Inferred Statistics for Functions of Multiple Phenotypes  Harold A. Nieuwboer, René Pool, Conor V. Dolan, Dorret I. Boomsma, Michel G. Nivard  The American Journal of Human Genetics  Volume 99, Issue 4, Pages 917-927 (October 2016) DOI: 10.1016/j.ajhg.2016.07.020 Copyright © 2016 American Society of Human Genetics Terms and Conditions

Figure 1 Manhattan Plot of BMI GWAS and GWIS Manhattan plots of −log p values for the (A) BMI GWAS as performed by Randall et al.5, (B) BMI GWIS using male height data, and (C) BMI GWIS using female height data. The location on the x axis corresponds to the genomic location of the SNP. In each figure, the blue line corresponds to p = 1 × 10−5 and the red line corresponds to p = 5 × 10−8. The American Journal of Human Genetics 2016 99, 917-927DOI: (10.1016/j.ajhg.2016.07.020) Copyright © 2016 American Society of Human Genetics Terms and Conditions

Figure 2 Comparison of BMI GWAS and BMI GWIS Summary Statistics Based on Male Height Data Scatterplots of BMI GWAS effect sizes versus GWIS (male height) (A) effect sizes, (B) standard errors, and (C) Z scores. The top left corner for each figure reports the squared correlation. The American Journal of Human Genetics 2016 99, 917-927DOI: (10.1016/j.ajhg.2016.07.020) Copyright © 2016 American Society of Human Genetics Terms and Conditions

Figure 3 Comparison of BMI GWAS and BMI GWIS Summary Statistics Based on Female Height Data Scatterplots of BMI GWAS effect sizes versus GWIS (female height) (A) effect sizes, (B) standard errors, and (C) Z scores. The top left corner for each figure reports the squared correlation. The American Journal of Human Genetics 2016 99, 917-927DOI: (10.1016/j.ajhg.2016.07.020) Copyright © 2016 American Society of Human Genetics Terms and Conditions

Figure 4 A Schematic Representation of the Role of GWISs in Relation to Traditional GWASs A GWIS provides a connection between several GWASs of phenotypes and a GWAS of a function of these phenotypes, without requiring access to the actual phenotypical data. The American Journal of Human Genetics 2016 99, 917-927DOI: (10.1016/j.ajhg.2016.07.020) Copyright © 2016 American Society of Human Genetics Terms and Conditions