Removing the Bone Brake

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Removing the Bone Brake Georg Schett, Aline Bozec Cell Metabolism Volume 20, Issue 3, Pages 394-395 (September 2014) DOI: 10.1016/j.cmet.2014.08.009 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Effect of the Anti-Sclerostin Antibody Romosuzumab on the Bone Osteocytes (blue) are embedded in the bone matrix (gray) and produce sclerostin as well as RANKL (orange). Sclerostin inhibits differentiation of bone-lining cells (red) into osteoblasts (green). Romosuzumab blocks sclerostin and removes the brake on Wnt protein-dependent osteoblast differentiation (arrow). Wnt proteins also stimulate the expression of osteoprotegerin (OPG), an inhibitor of RANKL, thereby blocking osteoclast-mediated bone resorption. Cell Metabolism 2014 20, 394-395DOI: (10.1016/j.cmet.2014.08.009) Copyright © 2014 Elsevier Inc. Terms and Conditions