Konstanze Lenhard, Guido T

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Analysis of promoter methylation in stool: A novel method for the detection of colorectal cancer Konstanze Lenhard, Guido T. Bommer, Silke Asutay, Rolf Schauer, Thomas Brabletz, Burkhard Göke, Rolf Lamerz, Frank T. Kolligs Clinical Gastroenterology and Hepatology Volume 3, Issue 2, Pages 142-149 (February 2005) DOI: 10.1016/S1542-3565(04)00624-X Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 (A) Location of the amplified region (underlined) of the HIC1 promotor by MSP. (B) Detection of unmethylated (u) and methylated (m) HIC1 promoter DNA in primary CRCs, (C) normal colonic epithelium, and (D) human peripheral blood leukocytes. (E) Analysis of sensitivity of the HIC1 MSP assay. Indicated genome equivalents of fully methylated DNA were spiked into normal stool DNA. Clinical Gastroenterology and Hepatology 2005 3, 142-149DOI: (10.1016/S1542-3565(04)00624-X) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 2 Detection of unmethylated (u) and methylated (m) HIC1 promoter DNA in stool samples from patients with (A) CRC, (B) adenoma, and (C) normal controls. Clinical Gastroenterology and Hepatology 2005 3, 142-149DOI: (10.1016/S1542-3565(04)00624-X) Copyright © 2005 American Gastroenterological Association Terms and Conditions