1. Low Frequency of Lynch Syndrome Among Young Patients With Non-Familial Colorectal Cancer 
Ajay Goel, Takeshi Nagasaka, Jennifer Spiegel, Richard Meyer, Warren E. Lichliter, C. Richard Boland 
Clinical Gastroenterology and Hepatology 
Volume 8, Issue 11, Pages e1 (November 2010)
DOI: /j.cgh
Copyright © 2010 AGA Institute Terms and Conditions

2. Figure 1
Relationship between location of tumor in the colon and various diagnostic features including DNA MMR-IHC status, MSI, KRAS and BRAF mutations. Blue bars represent frequency of tumors occurring in the distal colon, and orange bars are indicative of the proximal location. As shown, a majority of younger non-familial CRCs occur in the distal colon, and their location is independent of MMR status.
Clinical Gastroenterology and Hepatology 2010 8, e1DOI: ( /j.cgh )
Copyright © 2010 AGA Institute Terms and Conditions

3. Supplementary Figure 1
ROC illustrating sensitivity and specificity of pentaplex MSI assay used for detection of DNA MMR deficiency in our cohort of CRCs. There is a significantly high degree of correlation between mutations at microsatellite markers and corresponding loss in expression of MMR protein in younger non-familial CRCs.
Clinical Gastroenterology and Hepatology 2010 8, e1DOI: ( /j.cgh )
Copyright © 2010 AGA Institute Terms and Conditions