Effects of a human FABP7 point mutation on FABP7 protein structure

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Fig. 1 Effects of a human FABP7 point mutation on FABP7 protein structure. Effects of a human FABP7 point mutation on FABP7 protein structure. The FABP7 protein sequence contains three highly conserved motifs consisting of β sheets across FABP types. T61 is flanked by NLS and NES regions. T61 is located adjacent to F57, a site important for generating the NLS with the K21 domain that interacts with HSL. Upon ligand binding (that is, with DHA), a 3D conformational shift in the protein generates an NLS with K21 in WT FABP7, which is disrupted by the T61M variant, affecting nuclear localization and lipid-targeted transcriptional cascades. Jason R. Gerstner et al. Sci Adv 2017;3:e1602663 Copyright © 2017, The Authors