Fig. 3 Treating vaccinated mice with OVA-releasing scaffolds enhances angiogenesis and muscle regeneration following ischemic injury. Treating vaccinated.

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Fig. 3 Treating vaccinated mice with OVA-releasing scaffolds enhances angiogenesis and muscle regeneration following ischemic injury. Treating vaccinated mice with OVA-releasing scaffolds enhances angiogenesis and muscle regeneration following ischemic injury. In this figure, naïve + OVA denotes mice receiving no vaccination and implanted with an OVA-containing scaffold, vacc + blank denotes mice receiving vaccination with OVA/ALUM and a blank scaffold, and vacc + OVA denotes mice receiving vaccination with OVA/ALUM and an OVA-containing scaffold. (A) Ischemic hindlimbs in the various treatment groups were visually examined to determine the severity of hindlimb ischemia at 3, 7, and 14 days after ischemic ligation (n = 10 mice for naïve + OVA, n = 12 mice for vacc + blank, and n = 11 mice for vacc + OVA). (B) Representative histology images and quantification of CD31+ blood vessel densities in ischemic tissue adjacent to scaffold and ligation site in upper leg muscles at 14 days after ischemic ligation (n = 9 mice for naïve + OVA, n = 10 mice for vacc + blank, and n = 9 mice for vacc + OVA). Scale bars, 100 μm. (C) Representative laser Doppler perfusion images and quantification of ischemic to nonischemic blood perfusion ratio in various treated mice over the course of 14 days after ischemic ligation (n = 9 to 10 mice for naïve + OVA, n = 11 to 12 mice for vacc + blank, and n = 10 to 11 mice for vacc + OVA). (D and E) Quantification of percent area of skeletal muscle tissue with (D) ischemic muscle fibers and (E) regenerating muscle fibers in lower leg muscles downstream of the ligation site at 14 days after ischemic ligation (n = 9 mice for naïve + OVA, n = 11 mice for vacc + blank, and n = 10 mice for vacc + OVA). Data are presented as means ± SD. Significance is denoted by *P ≤ 0.05, **P ≤ 0.01, and ***P ≤ 0.001 by one-way ANOVA with Bonferroni’s post hoc test (photo credit: Brian Kwee, Harvard University). Brian J. Kwee et al. Sci Adv 2019;5:eaav6313 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).