BCX suppresses lung tumor, α7-nAChR expression, and α7-nAChR signaling in the NNK-treated mice. BCX suppresses lung tumor, α7-nAChR expression, and α7-nAChR.

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BCX suppresses lung tumor, α7-nAChR expression, and α7-nAChR signaling in the NNK-treated mice. BCX suppresses lung tumor, α7-nAChR expression, and α7-nAChR signaling in the NNK-treated mice. A, lung surface tumors (indicated by arrows) in the NNK-treated mice (left). H&E staining of the lung tissues with tumor regions shown under low and high magnification, middle and right, respectively. B, lung tumor multiplicity with different treatment. C, expression of α7-nAChR in lung tissue of mice without NNK treatment (left) and noncancerous lung tissue (middle) and lung tumor (right) of NNK-treated mice. Immunohistochemical localization of α7-nAChR (arrows) in the lung showing brownish cytoplasmic staining in airway epithelial cells, alveoli type II cells, and pulmonary alveolar macrophage, but intense staining in noncancerous lung tissue (middle) and lung tumor (right) of NNK-treated mice. D, levels of α7-nAChR mRNA with different treatment. E, levels of α7-nAChR protein with different treatment. F, quantification of the phosphorylated AKT (pAKT) on Ser473. G, the quantification of the phosphorylated BAD (pBAD) on Ser136. Group denotation: 1, control; 2, NNK; 3, NNK+BCX(1); 4, NNK+BCX(10). Abbreviations: BCX(1), β-cryptoxanthin 1 mg/kg diet; BCX(10), β-cryptoxanthin 10 mg/kg diet; nachr, nicotinic acetylcholine receptor; NNK, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Anita R. Iskandar et al. Cancer Prev Res 2016;9:875-886 ©2016 by American Association for Cancer Research