Bingbing Liang, Varun Mahans , Liesbet Geris

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Presentation transcript:

Bingbing Liang, Varun Mahans , Liesbet Geris Model assisted design of 3D printed biomaterials for optimized bone regeneration in alveolar bone Bingbing Liang, Varun Mahans , Liesbet Geris

The model design optimization progress is shown in the below flow chart. 3D structures In vitro experiment Structure optimization In vivo evaluation Application: alveolar bone regeneration Basic shape modeling 24/07/2019 All rights reserved © 2018

Work in progress Upcoming work 3D structures In vitro experiment Structure optimization In vivo evaluation Application: alveolar bone regeneration Basic shape modeling 24/07/2019 All rights reserved © 2018

The curvature-based principles to simulate the neotissue growth in the porous scaffold. Guyot et al. (2015) 24/07/2019 All rights reserved © 2018

Sintering Temperature The effects of multiple influencing factors have been verified through the pilot experiment. Pore shapes Pore size 0.5/0.7/1/2mm Materials HA/HA-TCP Sintering Temperature 1130/1230°C Cell type Human periosteum derived cells 2 mm The related variable: pore shapes, pore size, materials, sintering temperature, cell type Pilot plate: 3D printed, random distribution 24/07/2019 All rights reserved © 2018

The first result shows that the neotissue growth at experiment is much lower than computer modeling. Qualitatively, the curvature-based principle seems to hold for the tested experimental condition. Quantitatively, a recalibration of the advection velocity needs to be performed as the current value is too high in comparison to the results obtained for the CaP scaffold. 24/07/2019 All rights reserved © 2018

Conclusion 3D structures In vitro experiment Structure optimization In vivo evaluation Application: alveolar bone regeneration Basic shape modeling 24/07/2019 All rights reserved © 2018

Acknowledgements Names of co-authors Varun Manhas, France Lambert, Dorien Van Hede, Liesbet Geris This work is part of BIOPTOS, a certified BioWin project financed by the Walloon region (DG06). BL is funded by the National Fund for Scientific Research FNRS (T.0256.16)

References： [1] Guyot Yann. A multiphysics multiscale computational framework for the simulation of perfusion bioreactor processes in bone tissue engineering, 2015 24/07/2019 All rights reserved © 2018

Thank you for your attention! 24/07/2019 All rights reserved © 2018