Peter J. Barnes, DM, DSc, FRCP

Slides:

Advertisements

Similar presentations

Monoclonal antibodies and fusion proteins in medicine

Advertisements

A. Wesley Burks, MD, Susan Laubach, MD, Stacie M. Jones, MD

Different expression of cytokine and membrane molecules by circulating lymphocytes on acute mental stress in patients with atopic dermatitis in comparison.

The role of viruses in acute exacerbations of asthma

Road signs guiding leukocytes along the inflammation superhighway

Allergic Rhinitis and Its Impact on Asthma

Production of chemokines and proinflammatory and antiinflammatory cytokines by human alveolar macrophages activated by IgE receptors Philippe Gosset,

Alefacept (lymphocyte function-associated molecule 3/IgG fusion protein) treatment for atopic eczema Dagmar Simon, MD, Jennifer Wittwer, MD, Ganna Kostylina,

Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug- induced cutaneous eruptions Nikhil Yawalkar, MD, Maithili Shrikhande,

Mast cell–T cell interactions

Peter J. Barnes, FMedSci, FRS

Is 9 more than 2 also in allergic airway inflammation?

Thomas F. Tedder, PhD, Takashi Matsushita, MD, PhD

Identifying and Treating COPD in Cardiac Patients

Practice Notes from the AAAI

Histamine in the immune regulation of allergic inflammation

Inhibition of the IL-4/IL-13 receptor system prevents allergic sensitization without affecting established allergy in a mouse model for allergic asthma

Yuichi Teraki, MD, Aika Sakurai, MD, Seiichi Izaki, MD

Cellular and mediator responses twenty-four hours after local endobronchial allergen challenge of asthmatic airways Anthony J. Frew, MD, Johanne St-Pierre,

Inflammatory health effects of indoor and outdoor particulate matter

Practice Notes from the AAAAI

Obstructive sleep apnea

Biologics and biomarkers for asthma, urticaria, and nasal polyposis

A review of the current guidelines for allergic rhinitis and asthma

Pathophysiology of the inflammatory response

News & Notes Journal of Allergy and Clinical Immunology

The immunopharmacology of mild asthma

Circadian variation of sputum inflammatory cells in mild asthma

Drivers of chronic rhinosinusitis: Inflammation versus infection

Inflammatory cells, cytokine and chemokine expression in asthma immunocytochemistry and in situ hybridization Qutayba Hamid, MD, PhD, Editor Journal.

6. Asthma Journal of Allergy and Clinical Immunology

Epithelial cells as regulators of airway inflammation

Costimulatory molecules in the developing human gastrointestinal tract: A pathway for fetal allergen priming Catherine A. Jones, PhD, Gillian H.S. Vance,

Molecular virology and immunology of HIV infection

New concepts: The basophil

News & Notes Journal of Allergy and Clinical Immunology

Donald Y.M. Leung, MD, PhD Journal of Allergy and Clinical Immunology

Mechanisms of eosinophil-associated inflammation

Pathogenesis of allergic rhinitis

David M. Essayan, MD, Charity C

A randomized, double-blind trial of the effect of treatment with montelukast on bronchial hyperresponsiveness and serum eosinophilic cationic protein.

Chemokines and their receptors in allergic disease

The role and remediation of animal allergens in allergic diseases

Chemokines in seasonal allergic rhinitis

A New aDENNDum to Genetics of Childhood Asthma

Sachin K. Samuchiwal, PhD, Joshua A. Boyce, MD

Delayed eosinophil apoptosis in asthma

Molecular and cellular mechanisms of allergic disease

Increased adhesion to vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 of eosinophils from patients with asthma Lena Håkansson,

Practice Notes from the AAAI

Intranasal administration of eotaxin increases nasal eosinophils and nitric oxide in patients with allergic rhinitis Toyoyuki Hanazawa, MD, PhD, Julio.

Vanessa L. Ott, PhD, John C. Cambier, PhD

Releasing the Brakes on Cancer Immunotherapy

Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell–mediated allergic inflammation Yong-Jun Liu, MD, PhD Journal.

Robert P. Schleimer, PhD Journal of Allergy and Clinical Immunology

Chemokines and allergic disease

Abnormalities of cell and mediator levels in bronchoalveolar lavage fluid of patients with mild asthma Sally E. Wenzel, MD Journal of Allergy and Clinical.

Stefan Dunzendorfer, MDa, Nicole C

Footnotes1 Journal of Allergy and Clinical Immunology

Systemic effects of local allergic disease

The environmental predictors of allergic disease

Allergic and immunologic disorders of the eye

Mechanisms of allergic pulmonary eosinophilia in the mouse

Bruce K. Bacot, MD, Mary E. Paul, MD, Maritza Navarro, MD, Stuart L

Adipose tissue, adipokines, and inflammation

News & Notes Journal of Allergy and Clinical Immunology

Lisa A. Beck, MD, Sarbjit Saini, MD

Primary prevention of asthma and allergy

Airway smooth muscle: An immunomodulatory cell

Advances in mechanisms of allergic disease in 2016

Presentation transcript:

New directions in allergic diseases: Mechanism-based anti-inflammatory therapies Peter J. Barnes, DM, DSc, FRCP Journal of Allergy and Clinical Immunology Volume 106, Issue 1, Pages 5-16 (July 2000) DOI: 10.1067/mai.2000.107930 Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 1 Inhibition of cytokine synthesis. Several strategies are available to inhibit the production or effects of cytokines. Reprinted by permission from Nature Supplement 402:B31-8, copyright 1999 Macmillan Magazines Ltd. Journal of Allergy and Clinical Immunology 2000 106, 5-16DOI: (10.1067/mai.2000.107930) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 2 Inhibition of eosinophilic inflammation. Several strategies are possible to inhibit eosinophil inflammation in tissues, including immunomodulators, inhibitors of driving cytokines (IL-4 and IL-5), inhibition of critical adhesion molecules (VLA-4, selectins, and intercellular adhesion molecule 1), blockade of chemokine receptors on eosinophils (CCR3), and induction of apoptosis. MCP, Monocyte chemoattractant protein. Reprinted by permission from Nature Supplement 402:B31-8, copyright 1999 Macmillan Magazines Ltd. Journal of Allergy and Clinical Immunology 2000 106, 5-16DOI: (10.1067/mai.2000.107930) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 3 Inhibition of antigen-presenting cells and TH2 lymphocytes. Therapies are based on inhibition of co-stimulatory molecules (B7-2, CD28) and inhibition of IgE-driven antigen-presenting cells, nonselective immunomodulators, or cytokines that tip the balance away from TH1 cells toward TH2 cells (IFN-α, IL-12, and IL-18). TCR, T-cell receptor. Reprinted by permission from Nature Supplement 402:B31-8, copyright 1999 Macmillan Magazines Ltd. Journal of Allergy and Clinical Immunology 2000 106, 5-16DOI: (10.1067/mai.2000.107930) Copyright © 2000 Mosby, Inc. Terms and Conditions